Headache Prophylaxis By Cortico-brainstem Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$616,437.00
Summary
In this project we hope to discover the cause of migraine headache. Many triggers lead to migraine, but we do not know how. We believe the triggers produce a defect in pain control by the brainstem, which normally keeps sensation from the head below the pain threshold. In migraine, trigger factors acting high in the brain open a pain control gate lower in the brain, producing a migraine headache. If we can prove this, we can develop therapies that will prevent migraine before it starts.
Dopamine Mechanisms Conferring Resilience To Depression: A New Antidepressant Target
Funder
National Health and Medical Research Council
Funding Amount
$560,948.00
Summary
A significant proportion of people who suffer depression fail to obtain effective relief from either drugs or psychotherapy. Accordingly, there is a pressing need to develop new, and more effective, treatments. This project will determine whether certain specific brain pathways that use the transmitter dopamine can be manipulated in their activity so as to increase resilience to depression. This work has potential to provide the foundation for the development a new generation of antidepressants.