Preventing Perioperative Inadvertent Hypothermia In Adult Surgical Patients: The Development, Implementation And Evaluating Of An Evidence-based Care Bundle.
Funder
National Health and Medical Research Council
Funding Amount
$174,107.00
Summary
It is well established that keeping patients warm and preventing hypothermia before, during and after surgery leads to better outcomes. Although recommended practices for keeping a patient warm during surgery are relatively simple and inexpensive, they are often not adhered to in clinical practice. The aim of this implementation study is to improve compliance with evidence-based guidelines for the prevention of unplanned hypothermia in adult surgical patients.
Bridging The Gap In Kidney Transplantation Using Pigs As Donors
Funder
National Health and Medical Research Council
Funding Amount
$1,452,341.00
Summary
Chronic kidney failure results in patients suffering significant morbidity and mortality ultimately requiring life-supporting dialysis. Kidney transplantation and lifelong immunosuppression are the only treatment, but (i) is limited by the shortage of human donors and (ii) carries risks associated with these anti-rejection drugs. This project aims to solve both problems by using humanized pigs as donors combined with a novel approach to inducing acceptance of the transplanted kidneys.
Macrophages: A Therapeutic Target In Peritoneal Dialysis-induced Fibrosis?
Funder
National Health and Medical Research Council
Funding Amount
$593,888.00
Summary
Fibrosis (scar tissue) in the abdominal cavity is a common side-effect of peritoneal dialysis (a treatment for kidney failure), and results in a life-threatening loss of dialysis function. The cells causing the fibrosis are uncertain. This project asks: Are inflammatory cells (macrophages) the source of peritoneal scar tissue? What regulates the fibrotic process? Answers may lead to strategies to prevent fibrosis induced by peritoneal dialysis, abdominal surgery or other causes.
Effect Of Cross-linking Cytokines To Natural And Synthetic Matrices On Post-implantation Fibrosis In Animal Models
Funder
National Health and Medical Research Council
Funding Amount
$77,154.00
Summary
My research will focus on the development and in vivo testing of cytokine cross-linked surgical implant materials in selected mouse and rat models. We hypothesise that Follistatin bound to heparin sulphate cross-linked natural and synthetic matrix implants will suppress the formation of Extra cellular matrix around the implant during wound healing in a mouse surgical model.
The Role Of Flightless In The Formation Of Scar Formation And Potential As A Target For A Novel Therapy To Reduce Scarring
Funder
National Health and Medical Research Council
Funding Amount
$60,664.00
Summary
Scarring causes significant morbidity and suffering. It can lead to pain, disfigurement and impaired physical function, which require costly ongoing care. Flightless (Flii) is a novel protein, which acts as a negative regulator of wound healing. Flii neutralising antibody treatment has been shown to improve wound healing. However, the role of Flii in scarring has yet to be investigated. This project will investigate the role of Flii in scarring and its potential as a therapeutic target.
Epidemiology, Diagnosis And Treatment Of Orthopaedic Infections
Funder
National Health and Medical Research Council
Funding Amount
$93,655.00
Summary
Orthopaedic surgery has led to significant improvements in patient's quality of life. With an ageing population, the number of patients requiring joint replacement and other bone and joint surgery will increase exponentially. Infection of the joint replacement is a devastating complication of this surgery. Research into these infections is still evolving. This research proposal aims to examine the clinical features of bone and joint infections, to explore ways to optimise diagnosis and improve t ....Orthopaedic surgery has led to significant improvements in patient's quality of life. With an ageing population, the number of patients requiring joint replacement and other bone and joint surgery will increase exponentially. Infection of the joint replacement is a devastating complication of this surgery. Research into these infections is still evolving. This research proposal aims to examine the clinical features of bone and joint infections, to explore ways to optimise diagnosis and improve treatment and outcomes for patients.Read moreRead less