Characterisation Of Anti-HBs Responses In Patients Undergoing Functional Hepatitis B Cure: Implication For Future Therapies
Funder
National Health and Medical Research Council
Funding Amount
$723,649.00
Summary
The hepatitis B virus causes liver cirrhosis and liver cancer. There is no cure for hepatitis B. However, a small number of patients can naturally rid themselves of the virus. We have identified 14 of these individuals and discovered that they have a unique immune response that is responsible for these “natural” cures. We plan to characterise this immune response and turn it into a therapeutic vaccine which can be used to cure patients who are still chronically infected.
Generation Of Protective Immunity Against Severe Influenza Disease In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,630,970.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.
A Randomised Controlled Trial Examining Stability Of New Types Of Highly Porous Surfaced Acetabular Components In Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$216,490.00
Summary
Numbers of total hip replacements are steadily increasing. The most common complication of hip replacement is late implant loosening, which can be predicted by early migration. We will examine early migration of a trabecular metal acetabular cup without screws, compared to a titanium fibre metal acetabular cup fixed with screws. Ideally, an acetabular cup would achieve a level of initial stability by press-fit alone without screws, as screws increase the risk of bone loss around the prosthesis.
Discovery Early Career Researcher Award - Grant ID: DE240100161
Funder
Australian Research Council
Funding Amount
$407,598.00
Summary
Translational Design: Product Development for Research Commercialisation. Australia is a world leader in fundamental research. Yet, ranks as one of the worst developed nations for translating research into new-to-market innovation. This project explores a new role for design as a critical component of research commercialisation and innovation ecosystems. It expects to contribute novel insights into how designers can be better integrated into interdisciplinary research directed towards commercial ....Translational Design: Product Development for Research Commercialisation. Australia is a world leader in fundamental research. Yet, ranks as one of the worst developed nations for translating research into new-to-market innovation. This project explores a new role for design as a critical component of research commercialisation and innovation ecosystems. It expects to contribute novel insights into how designers can be better integrated into interdisciplinary research directed towards commercial outcomes. Expected outcomes include a framework and toolkit for a paradigm-shifting design approach to translating fundamental research into products commercialised and manufactured in Australia. This should provide enhanced economic benefit, building Australia’s sovereign capability in new-to-market innovation.Read moreRead less
Digital fabrication technologies: analysing patterns of adoption and innovative transformations in architectural design and practice. This project on adoption of digital fabrication technologies by Australian architecture practices will reveal emerging opportunities for creative design and associated transformations in the design practices. These outcomes will enable the increasingly globalising sector of architectural design services to become more agile and innovative.
Muscle memory: The key to novel interactive memory support systems. This project aims to investigate how the use of muscle memory as a deliberate interaction design resource can effectively support declarative memory. The project brings together memory interaction design and bodily activity design to address increasing concerns surrounding Australians’ memory. By investigating muscle memory in interaction design, the project is expected to advance international understanding of scholarly and pra ....Muscle memory: The key to novel interactive memory support systems. This project aims to investigate how the use of muscle memory as a deliberate interaction design resource can effectively support declarative memory. The project brings together memory interaction design and bodily activity design to address increasing concerns surrounding Australians’ memory. By investigating muscle memory in interaction design, the project is expected to advance international understanding of scholarly and practical processes that complement design for declarative memory. The project will lay the foundation for extending research which will assist movement, rehabilitation, health and educational sports practitioners that can create engaging experiences that use muscle memory for the benefit of all Australians.Read moreRead less
Radiostereometric Analysis Of The Effect Of A Large Articulation On Prosthetic Wear And Migration After Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$192,186.00
Summary
At total hip replacement, there has been a recent trend to use prostheses with a larger ball and liner in the socket. This may decrease the risk of post-operative dislocation, but may also increase the amount of wear, leading to bone loss and loosening of prostheses, which may then require replacement. This project will use a special type of x-ray to determine whether wear and movement of these new prostheses is clinically acceptable, so that they can be used with confidence in patients.
The Analects of Antoni Gaudí. This project aims to investigate and record the missing dimensions of Antoni Gaudí's theoretical position and his way of working. Gaudí (1852-1926) is one of the most important figures in world architecture and a major shaper of modern culture, but wrote nothing on his theory or practice of architecture. Given its holism, aesthetic, structural and artistic richness, this is a problem for scholars. Work to complete the Sagrada Família, a living laboratory of conspicu ....The Analects of Antoni Gaudí. This project aims to investigate and record the missing dimensions of Antoni Gaudí's theoretical position and his way of working. Gaudí (1852-1926) is one of the most important figures in world architecture and a major shaper of modern culture, but wrote nothing on his theory or practice of architecture. Given its holism, aesthetic, structural and artistic richness, this is a problem for scholars. Work to complete the Sagrada Família, a living laboratory of conspicuously innovative architecture, is entering its final stages with anticipated completion in 2026. This presents a last opportunity to capture, interpret and disseminate Gaudí’s thoughts and analects for dissemination to the next generation of architects.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100630
Funder
Australian Research Council
Funding Amount
$401,000.00
Summary
Translating ambiance: restorative sound design for urban soundscapes. This project aims to address the issue of sensory overload caused by noise pollution, which can be a significant stressor and threat to wellbeing. The project expects to produce innovations in the area of urban soundscape design by combining biophilic design and ambiance theory. Expected outcomes of this project include new techniques for the creation of sound art installations that advance the effectiveness of urban renewal i ....Translating ambiance: restorative sound design for urban soundscapes. This project aims to address the issue of sensory overload caused by noise pollution, which can be a significant stressor and threat to wellbeing. The project expects to produce innovations in the area of urban soundscape design by combining biophilic design and ambiance theory. Expected outcomes of this project include new techniques for the creation of sound art installations that advance the effectiveness of urban renewal initiatives. This project should provide significant benefits, such as improving the quality of life in urban centres by producing restful and restorative places, and identifying pathways for the involvement of creative practitioners in the design and management of the built environment.Read moreRead less
Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to b ....Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to be considered for each design decision. This will greatly reduce rework and poor design decisions based on missed information. It will also ensure that participants are aware of all related information for their particular design tasks.Read moreRead less