Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
TRANSIENT VIBRATION IN PIPELINE SYSTEMS. Although the threat of transient vibration to the safety of pipeline systems has been widely recognised, neither the coupling characteristics in transient wave propagation are clearly understood, nor accurate tools are available for analysing them. The aims of this project are to develop effective analytical and experimental methods, to study the interactions between transient waves of different types at pipe joints and bends, and to experimentally charac ....TRANSIENT VIBRATION IN PIPELINE SYSTEMS. Although the threat of transient vibration to the safety of pipeline systems has been widely recognised, neither the coupling characteristics in transient wave propagation are clearly understood, nor accurate tools are available for analysing them. The aims of this project are to develop effective analytical and experimental methods, to study the interactions between transient waves of different types at pipe joints and bends, and to experimentally characterise the transient excitations. The understanding and techniques developed from this project hold promise in providing reliable tools for safe design of complex pipeline systems in petroleum, chemical and refinery industries.Read moreRead less
Trustworthy positioning for intelligent transport systems. This project aims to develop a holistic approach for reliable positioning for Intelligent Transport Systems (ITS). This project will address the challenges of integrity monitoring in ITS when using satellite-based technology, its integration with other sensors, and when supported by the proposed Australia National Positioning Infrastructure. It will consider Australian geography, large area, and sparse population, and emphasise rural tra ....Trustworthy positioning for intelligent transport systems. This project aims to develop a holistic approach for reliable positioning for Intelligent Transport Systems (ITS). This project will address the challenges of integrity monitoring in ITS when using satellite-based technology, its integration with other sensors, and when supported by the proposed Australia National Positioning Infrastructure. It will consider Australian geography, large area, and sparse population, and emphasise rural transport. Expected primary outputs include algorithms, a detailed analysis of required systems and recommendations that will help prepare Australia for the importation of self-driving vehicles.Read moreRead less
'Just right' job design: A new model using the Goldilocks paradigm. This proposal will generate new knowledge about designing jobs with the right amount of human movement. Prolonged sitting is now a serious work hazard that contributes to cardiovascular risk and obesity. The high incidence of these conditions in many work systems, such as rail, also presents a critical safety hazard due to threat of sudden incapacity while driving. Expected project outcomes are a ‘Just Right’ Job Design model sh ....'Just right' job design: A new model using the Goldilocks paradigm. This proposal will generate new knowledge about designing jobs with the right amount of human movement. Prolonged sitting is now a serious work hazard that contributes to cardiovascular risk and obesity. The high incidence of these conditions in many work systems, such as rail, also presents a critical safety hazard due to threat of sudden incapacity while driving. Expected project outcomes are a ‘Just Right’ Job Design model showing how tasks can be designed to enhance safety and health while maintaining productivity, and in the unlikeliest of workplaces. This will provide significant benefits for the many working Australians whose safety and health are compromised by exposure to prolonged sitting in seemingly intractable environments.Read moreRead less
Towards A National Sports Safety Strategy - Addressing Facilitators And Barriers Towards Safety Guideline Uptake.
Funder
National Health and Medical Research Council
Funding Amount
$965,834.00
Summary
Most sports injury prevention evidence is yet to be translated from professional to community sports settings. Using community-based Australian football clubs, this project will develop and evaluate the strategic implementation of an evidence-based sports safety package. This will provide important information about how to best support community sports clubs to ensure evidence-based safety programs are translated into sustainable policies and practice and public health benefits are maximised
How leaders integrate safety goals for employees to build adaptive safety capabilities in organisations. How can organisations maintain high levels of safety while adapting to constant technological, social, and economic change? This project will investigate how leaders align complex individual goals to develop adaptive safety capability: the capacity of organisations to successfully modify safety systems in the midst of change.
Mid-Career Industry Fellowships - Grant ID: IM230100702
Funder
Australian Research Council
Funding Amount
$859,472.00
Summary
Optimising sleep, alertness and safety in shift work industries. This project aims to address the impaired alertness, and high risk of workplace errors and accidents that are associated with sleep loss and circadian misalignment during shift work. The project will deliver an innovative industry-driven digital technology to provide automated, customised sleep management strategies to shift workers, and will develop a framework for effective wide-scale deployment of the technology within Australia ....Optimising sleep, alertness and safety in shift work industries. This project aims to address the impaired alertness, and high risk of workplace errors and accidents that are associated with sleep loss and circadian misalignment during shift work. The project will deliver an innovative industry-driven digital technology to provide automated, customised sleep management strategies to shift workers, and will develop a framework for effective wide-scale deployment of the technology within Australian shift working organisations. The project will close the gap in resources currently available to support sleep in shift workers and will reduce the significant burdens of shift work for alertness, productivity and safety.Read moreRead less
Avoiding catastrophic failure of cable bolts in underground mines. This work aims to identify the factors responsible for the emerging problem of catastrophic failure of high-load cable bolts in underground mines and develop strategies for resisting their failure. The work is of high importance since failure of cable bolts is now being reported in several mines across Australia and is expected to become a problem world-wide. The work is novel as it intends to be the very first study of catastrop ....Avoiding catastrophic failure of cable bolts in underground mines. This work aims to identify the factors responsible for the emerging problem of catastrophic failure of high-load cable bolts in underground mines and develop strategies for resisting their failure. The work is of high importance since failure of cable bolts is now being reported in several mines across Australia and is expected to become a problem world-wide. The work is novel as it intends to be the very first study of catastrophic cable bolt failure. The expected outcome is the development of economically viable solutions for avoiding catastrophic cable bolt failure. It is anticipated that the findings will also be relevant to the civil engineering sector.Read moreRead less
Stimulation of the mammalian reproductive system by olfactory pathways. This project answers fundamental questions about mammalian reproductive biology but, because we work with the sheep model, our findings can be applied to two of Australia's biggest export industries, wool and sheepmeat. Understanding the reproductive responses of our production animals to exteroceptive factors such as socio-sexual signals, photoperiod and nutrition is an important first step towards refining the management ....Stimulation of the mammalian reproductive system by olfactory pathways. This project answers fundamental questions about mammalian reproductive biology but, because we work with the sheep model, our findings can be applied to two of Australia's biggest export industries, wool and sheepmeat. Understanding the reproductive responses of our production animals to exteroceptive factors such as socio-sexual signals, photoperiod and nutrition is an important first step towards refining the management of breeding programs. It has been argued that this approach will also minimise, and perhaps even remove the need for, exogenous hormones and drugs for controlling the reproductive process.Read moreRead less
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.