Protein Kinases Regulate Salt Reabsorption In The Kidney
Funder
National Health and Medical Research Council
Funding Amount
$531,696.00
Summary
This proposal is designed to determine how the kidney senses the level of salt in the body and monitors blood pressure. This is critical for diseases such as hypertension, kidney and heart failure, where salt is retained inappropriately. We propose that the kidney uses proteins called kinases that are activated by salt in the kidney. When it is too low, they detect this and cause the kidney to absorb more salt to correct the deficiency. The way that they are able to do this has profound implicat ....This proposal is designed to determine how the kidney senses the level of salt in the body and monitors blood pressure. This is critical for diseases such as hypertension, kidney and heart failure, where salt is retained inappropriately. We propose that the kidney uses proteins called kinases that are activated by salt in the kidney. When it is too low, they detect this and cause the kidney to absorb more salt to correct the deficiency. The way that they are able to do this has profound implications for human heart and kidney disease, and biology in general.Read moreRead less
While we need to consume salt, too much can be harmful and is in fact directly linked to ~5% of deaths annually in Australia. We have identified a system in the brain that regulates salt intake. Going forwards we will fully elucidate the pathway(s) implicated in regulation of salt intake, thereby identifying strategies to reduce excessive salt consumption.
Role Of AMP-activated Protein Kinase In Salt Excretion And Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
High blood pressure is a significant health problem and may result from the kidneys not being able to get rid of salt properly. The mechanisms underlying this are unclear. I will investigate the role of a kidney protein, called AMPK, in salt excretion in mice. I will also look at the effects that diabetes and obesity have on the function of this protein. The overall aim is to improve the understanding of what causes high blood pressure which will ultimately aid the development of new treatments ....High blood pressure is a significant health problem and may result from the kidneys not being able to get rid of salt properly. The mechanisms underlying this are unclear. I will investigate the role of a kidney protein, called AMPK, in salt excretion in mice. I will also look at the effects that diabetes and obesity have on the function of this protein. The overall aim is to improve the understanding of what causes high blood pressure which will ultimately aid the development of new treatments for it.Read moreRead less
Developing A National Salt Reduction Program For India
Funder
National Health and Medical Research Council
Funding Amount
$93,626.00
Summary
While the scientific evidence base providing the rationale for salt reduction in controlling hypertension is very strong, the data required to translate those scientific insights into policy and reduced population salt intake are mostly absent. Few countries, India included, have the data required to develop, implement and evaluate salt reduction programs tailored to their national circumstances. The overall goal of this 3-year project is to develop the evidence base required to formulate a nati ....While the scientific evidence base providing the rationale for salt reduction in controlling hypertension is very strong, the data required to translate those scientific insights into policy and reduced population salt intake are mostly absent. Few countries, India included, have the data required to develop, implement and evaluate salt reduction programs tailored to their national circumstances. The overall goal of this 3-year project is to develop the evidence base required to formulate a national salt reduction program for India.Read moreRead less
International Strategies To Reduce Population Salt Intake
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Effective, sustainable and scalable strategies to reduce salt are needed so countries can achieve the global target to reduce salt by 30% by 2025. This research program will support the optimal development of such strategies through trials and intervention research projects, supplemented through a series of systematic reviews and feasibility and cost-effectiveness assessments. The main outcome will be new evidence on the effectiveness of different interventions to support translation globally.