Exploration Of Exposures Associated With Bedding That Are Risks For Childhood Allergy And Asthma Symptoms
Funder
National Health and Medical Research Council
Funding Amount
$263,500.00
Summary
Asthma prevalence in Australia has doubled in the last 20 years, with 1 in 4 children now affected. House dust mites are probably the single most important allergen associated with asthma. The prevalence of mite allergy is linked to exposure, and such allergy when combined with high exposure, is a potent risk factor for asthma exacerbations. The current international advice for managing mite-allergic asthma, strongly advocates the use of bedding encasings as the best way to reduce exposure. Howe ....Asthma prevalence in Australia has doubled in the last 20 years, with 1 in 4 children now affected. House dust mites are probably the single most important allergen associated with asthma. The prevalence of mite allergy is linked to exposure, and such allergy when combined with high exposure, is a potent risk factor for asthma exacerbations. The current international advice for managing mite-allergic asthma, strongly advocates the use of bedding encasings as the best way to reduce exposure. However, three recent major trials using encasings and a meta-analysis of earlier trials all fail to show a clinical benefit. One of the applicants (ET) recently showed, using expertise in measuring personal exposure, that these encasings, as used, fail to significantly reduce aeroallergen exposure. By contrast, 3 recent Australian studies, involving the applicants, AK, ALP and NG showed that feather bedding compared to synthetic bedding, was strongly protective for asthma - the opposite of public advice. The suggested mechanisms involve reduced exposure to mite allergens, or altered exposure to bacterial endotoxin, but persuasive experimental support is lacking. We also propose a novel hypothesis that feather exposure may induce allergic 'tolerance'. Currently there is a lack of certainty about valid approaches to prevent asthma, and the Global Initiative for Asthma has described the need to understand mechanisms and improve interventions as urgent. This project is an ideal opportunity to combine the expertise of the CIA (ET) in measuring airborne exposures (mite, endotoxin, proteins) with that of the others who have expertise in children's asthma, and who are already involved in two large clinical trails involving different bedding and allergen avoidance. Our measurements of these bedding exposures and their clinical outcomes will provide, for the first time, a quantitative basis to refine public health allergen-based interventions to prevent and manage asthma.Read moreRead less
Air Pollution And Mortality And Morbidity In Adult Australians (APMMA Study): A Large Population Based Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$1,041,410.00
Summary
This study will investigate the link between respiratory and cardiovascular disease and mortality and exposure to long-term air pollution. We will use cutting edge methods to assign neighbourhood air pollution levels to a large cohort of NSW adults (n>265,000) previously recruited in the 45 and Up Study. The study results will be of utmost importance in setting outdoor air pollution standards and informing cost benefit analyses of air pollution control strategies.
Tracking Epidermal Clonal Evolution During Skin Cancer Induction And Progression
Funder
National Health and Medical Research Council
Funding Amount
$558,168.00
Summary
Skin cancer is the most frequent form of cancer in Australia and in many parts of the world. It is strongly connected to ultraviolet radiation from the sun. In this project, we will use our capacity to track individual cells, to observe the heterogeneity of tumours and the lesions that precede them. We will show the importance of this heterogeneity in tumour progression unveiling the limits of current therapies against skin cancer.
Susceptibility Of The Basal Layer Of Human Epidermis To UVA Oxidative Damage Due To Pheomelanin And Suboptimal DNA Repair
Funder
National Health and Medical Research Council
Funding Amount
$559,354.00
Summary
Australia has the highest incidence of skin cancer in the world. It is important to understand how sunlight causes skin cancer and the wavelengths involved in order to devise effective preventative and therapeutic strategies. Our proposal is that the cells in the skin that give rise to the most common forms of skin cancer, squamous cell carcinoma and basal cell carcinoma, are particularly vulnerable to UVA. We aim to study why this is the case and whether this vulnerability can be prevented.
Infectious And Lifestyle Determinants Of Non-melanoma Skin Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$983,711.00
Summary
Basal and squamous cell skin cancers are the leading cancers in Australia, with about 2% of the population developing them each year. As well as sun exposure, a number of other factors have been thought to effect these cancers. This study will examine if factors such as smoking, alcohol consumption and infection with certain skin related human papillomaviruses also increase their risk. Even a small effect may make a big difference when it comes to preventing these common cancers.
HIV Assembly, Transport, Egress And Transfer From Infected Dendritic Cells
Funder
National Health and Medical Research Council
Funding Amount
$511,629.00
Summary
HIV-AIDS is the fourth leading killing disease worldwide, with the disease burden shifting towards women. Study of the HIV life cycle in cells known to be targetted during HIV transmission is key towards designing additional preventative measures in the form of topical gels known as microbicides. Mapping of the basic pathways of viral transport within such cells, will aid further drug discovery and-or appropriateness of use of existing drugs in microbicide formulations.
Science and the Shaping of Modernity, 1690-1755. It is important that we understand the values underlying our culture, and one form of such understanding is historical. The idea that science provides the standards for all forms of cognitive enquiry is an intrinsic part of modern culture, and the notions of impartiality and objectivity that it is taken to express are closely tied in with estimations of the value of our culture. The history of how this conception emerged in the early-modern period ....Science and the Shaping of Modernity, 1690-1755. It is important that we understand the values underlying our culture, and one form of such understanding is historical. The idea that science provides the standards for all forms of cognitive enquiry is an intrinsic part of modern culture, and the notions of impartiality and objectivity that it is taken to express are closely tied in with estimations of the value of our culture. The history of how this conception emerged in the early-modern period shows that there was nothing self-evident in the assimilation of cognitive values to scientific ones, however, or in the extrapolation of these to general cultural and political values. Read moreRead less
The persona of the philosopher in early modern Europe. The project aims to provide a new interpretation of the history of early modern European philosophy, organised around the key concept of the persona of the philosopher. By focusing on the shaping and reshaping of the philosophical persona - understood as a self cultivated for the purposes of conducting philosophical life and learning - the project will offer novel and fundamental insights into conflicts over the character of philosophy, its ....The persona of the philosopher in early modern Europe. The project aims to provide a new interpretation of the history of early modern European philosophy, organised around the key concept of the persona of the philosopher. By focusing on the shaping and reshaping of the philosophical persona - understood as a self cultivated for the purposes of conducting philosophical life and learning - the project will offer novel and fundamental insights into conflicts over the character of philosophy, its disciplinary borders, its relation to the new scientific enterprises of the era, and its relation to civil and religious life.Read moreRead less
The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly enga ....The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly engage questions of value in a novel and revealing way, and how its connection with 'hard' sciences was not merely to provide a methodological gloss on these, but went to the core of what scientific explanation consisted in.Read moreRead less
A history of terra nullius. The concept of 'terra nullius' has been central to debates concerning the land rights of indigenous peoples. The term, however, has been understood almost in an historical vacuum. Partly in consequence, landmark legal rulings supposedly overturning the doctrine of terra nullius have left European colonisers' justifications of their appropriation of land largely conceptually intact. The central innovation of this history will be to show that when terra nullius, prop ....A history of terra nullius. The concept of 'terra nullius' has been central to debates concerning the land rights of indigenous peoples. The term, however, has been understood almost in an historical vacuum. Partly in consequence, landmark legal rulings supposedly overturning the doctrine of terra nullius have left European colonisers' justifications of their appropriation of land largely conceptually intact. The central innovation of this history will be to show that when terra nullius, properly understood, is rejected in order to establish native title, the implications for the European tradition of property rights and human rights more generally will be profound.Read moreRead less