Developing Interpretable Machine Learning Models For Clinical Imaging And Single-cell Genomics
Funder
National Health and Medical Research Council
Funding Amount
$1,312,250.00
Summary
Machine learning methods will be vital to make best use of the deluge of data generated by high-throughput technologies in biomedical science. To get the most out of these models, however, we need to be able to unpack the 'black box'. I will use curated clinical and public research data to benchmark and develop interpretable deep learning models and software tools. These models will be used for breast cancer screening programs and for analysis of complex, large-scale single-cell genomics data.
REACH: Randomised Trial Of EArly Rehabilitation In Congenital Hemiplegia
Funder
National Health and Medical Research Council
Funding Amount
$972,777.00
Summary
Infants with asymmetric brain lesions are at high risk of congenital hemiplegia. This study compares modified CIMT to an equal dose of bimanual training in 150 infants recruited at 3-6 months. Both therapies will be parent-delivered supported by experienced clinicians. Outcomes include use of the impaired hand in bimanual tasks, cognitive and motor development at 12 and 24 months c.a. with measures of neural structure and functional connectivity at 24 months. Early interventions that attenuate
A Pedagogy for Multiliteracies with Information and Communication Technologies in Early Childhood Education. The goal of this project is to determine the most effective pedagogy for the use of ICT in Australian early childhood education. The research is essential in order to plan for a world-class educational future for young Australians. A collaborative action-research program will be undertaken by three leading academics in association with a network of thirty-six teachers in three states. Thi ....A Pedagogy for Multiliteracies with Information and Communication Technologies in Early Childhood Education. The goal of this project is to determine the most effective pedagogy for the use of ICT in Australian early childhood education. The research is essential in order to plan for a world-class educational future for young Australians. A collaborative action-research program will be undertaken by three leading academics in association with a network of thirty-six teachers in three states. This innovative research approach is based on a multiliteracies framework. The project will investigate how ICT can best be used for enhancing children's learning and identify specific ways in which teachers can develop multiliteracies in early childhood education environments. Read moreRead less
Quality and outcomes of individual supported living arrangements for adults with intellectual and developmental disabilities. This project identifies service quality aspects contributing to positive outcomes in individual supported living arrangements that enable adults with developmental disabilities to live in their own homes. 150 arrangements will be evaluated across Western Australia, New South Wales and Victoria, providing evidence of service quality in support of people with disability hav ....Quality and outcomes of individual supported living arrangements for adults with intellectual and developmental disabilities. This project identifies service quality aspects contributing to positive outcomes in individual supported living arrangements that enable adults with developmental disabilities to live in their own homes. 150 arrangements will be evaluated across Western Australia, New South Wales and Victoria, providing evidence of service quality in support of people with disability having choice and control in their living arrangements.Read moreRead less
Optimising Benefits And Minimising Potential Harms Of Obesity Treatments
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
This work aims to find safe and more effective obesity treatments for the over 2.1 billion people worldwide with overweight or obesity. Severely energy restricted diets are currently the most effective dietary obesity treatment, but these are underutilized due to concerns about potential harms. This work will investigate using severe diets intermittently rather than continuously, as a means of enhancing their benefits of long-term weight/fat loss while also reducing potential harmful effects.
Improving Weight Loss By Intermittent Use Of Very Low Energy Diet: The TANGO Diet Trial (Temporary Phases Of Accelerated Weight Loss For Noticeably Greater Outcomes)
Funder
National Health and Medical Research Council
Funding Amount
$660,736.00
Summary
Very low energy diet (VLED) is being increasingly used for the treatment of obesity, but the resultant weight loss is usually transient, partly because it induces powerful adaptive responses that inhibit weight loss and promote regain. We have shown that 'taking a break from dieting' for 2 weeks reduces these adaptive responses. In this project we will thus test whether weight loss outcomes with VLED can be improved via intermittent use, where periods on the VLED are alternated with 'breaks'.
Better Planning for and Managing Asymmetric Threats to Australia's Security: Applying the Field Anomaly Relaxation (FAR) Systems Thinking Approach. Despite an enviable national security condition, Australia is at risk in an information-abundant world that increasingly spawns asymmetric threats such as information terrorism. What is needed are enhanced strategic and operational structures to improve the nation's security and ensure sound futures planning. This research focuses on applying the Fie ....Better Planning for and Managing Asymmetric Threats to Australia's Security: Applying the Field Anomaly Relaxation (FAR) Systems Thinking Approach. Despite an enviable national security condition, Australia is at risk in an information-abundant world that increasingly spawns asymmetric threats such as information terrorism. What is needed are enhanced strategic and operational structures to improve the nation's security and ensure sound futures planning. This research focuses on applying the Field Anomaly Relaxation (FAR) systems thinking approach to asymmetric information warfare threats to Australia. This is a new approach previously developed by ECU researchers investigating risk and innovation in the armed forces. It will now be extended to improve professional practice and the knowledge and skill base of Australia's information defence practitioners.Read moreRead less
Australasian Cerebral Palsy Clinical Trials Network (AusCP-CTN): Optimising Interventions And Effective Services For Children With Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$2,499,287.00
Summary
Cerebral Palsy (CP) is common and disability can be progressive so the heathcare burden is immense (0.14% GDP). Our Clinical trials network will improve early detection and develop new interventions to improve physical, cognitive and health outcomes for children with CP and their families. Recruitment from the national CP Register will address clinically important questions and test implementation of effective treatments. New Clinical Practice Guidelines will ensure translation internationally.
Discovery Early Career Researcher Award - Grant ID: DE180101503
Funder
Australian Research Council
Funding Amount
$357,996.00
Summary
Using improved markets to reduce over-extraction of groundwater. This project aims to investigate the key aspects needed for a successful groundwater market, including extraction limits, innovative trading systems and reasonable transaction costs. The outcomes of the project can contribute to environmental benefits that minimise short-term financial losses to irrigators. The project also expects to enhance the capacity of water agencies to implement cap and trade systems that can reduce over-ext ....Using improved markets to reduce over-extraction of groundwater. This project aims to investigate the key aspects needed for a successful groundwater market, including extraction limits, innovative trading systems and reasonable transaction costs. The outcomes of the project can contribute to environmental benefits that minimise short-term financial losses to irrigators. The project also expects to enhance the capacity of water agencies to implement cap and trade systems that can reduce over-extraction.Read moreRead less
Benefits and costs of non-market valuation for environmental management. Benefits from environmental policies are often unpriced “non-market values” (NMVs). Environmental agencies struggle to know how best to measure these relatively intangible benefits, but doing so is important to ensure value for money from public investments. Environmental economists have developed and applied a wide range of methods for estimating NMVs. The methods vary in their comprehensiveness, accuracy and cost. Yet no ....Benefits and costs of non-market valuation for environmental management. Benefits from environmental policies are often unpriced “non-market values” (NMVs). Environmental agencies struggle to know how best to measure these relatively intangible benefits, but doing so is important to ensure value for money from public investments. Environmental economists have developed and applied a wide range of methods for estimating NMVs. The methods vary in their comprehensiveness, accuracy and cost. Yet no rigorous tool is available to assess (a) which NMV method is best to implement, accounting for its cost and its potential to improve decisions, or (b) whether any NMV method improves decisions enough to warrant its cost. In creating such a tool, this project will deliver a key breakthrough in environmental economics.Read moreRead less