Epimutations As Germ-line Defects In Hereditary Cancer Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$385,925.00
Summary
Traditionally familial cancers were thought to be caused and inherited by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that a 'chemical coat' around the MLH1 gene, causing it to be switched off, can also be inherited in some cases of bowel cancer, without any mistakes within the gene's code. We will determine if this 'coat' causes other types of cancer and if this runs in families. We also hope to find out how the coat is formed and may be reversed.
The Role And Inheritance Of Constitutional Epimutations In Early-onset Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$347,551.00
Summary
Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.
Patient and nurse outcomes and the cost of nurses' turnover in Australian hospitals. An adequate supply of nurses is fundamental to all of the National Health Priority disease areas where quality care cannot be delivered without an adequate number of motivated nurses. Designing cost-effective methods of retaining nurses requires understanding reasons why they leave the workforce and the impact this has on patient care and system costs. The findings will assist policy makers and workforce planner ....Patient and nurse outcomes and the cost of nurses' turnover in Australian hospitals. An adequate supply of nurses is fundamental to all of the National Health Priority disease areas where quality care cannot be delivered without an adequate number of motivated nurses. Designing cost-effective methods of retaining nurses requires understanding reasons why they leave the workforce and the impact this has on patient care and system costs. The findings will assist policy makers and workforce planners at both local and national levels, to design strategies to effectively recruit and retain nurses as demands for health care and market competition for staff both increase.Read moreRead less
Active citizenship of young people through electoral enrolment. Some 300,000 eighteen to twenty-four year old Australians are not enrolled to vote in federal elections, despite compulsory voting. Consequently they do not exercise their rights, and their responsibilities, as citizens in this way. The Australian Ele ctoral C ommission and the researchers will determine why these young Australians are not enrolled and do not vote. We will identify the characteristics of non-participants particularl ....Active citizenship of young people through electoral enrolment. Some 300,000 eighteen to twenty-four year old Australians are not enrolled to vote in federal elections, despite compulsory voting. Consequently they do not exercise their rights, and their responsibilities, as citizens in this way. The Australian Ele ctoral C ommission and the researchers will determine why these young Australians are not enrolled and do not vote. We will identify the characteristics of non-participants particularly those from rural and regional areas. Outcomes include identification of non-enrolled youth and appropriate interventions to engage young Australians to become active, democratic citizens....Read moreRead less