Hypertension (high blood pressure) is the commonest chronic condition in western societies, and can lead to strokes, heart attacks and kidney failure. In a disease known as primary aldosteronism (PAL), hypertension results from the excessive production of the salt-retaining hormone, aldosterone, by the the body's adrenal glands. In some patients, this is due to the growth of an aldosterone-producing adrenal tumour. Recent work performed within the Hypertension Unit at Greenslopes Hospital and co ....Hypertension (high blood pressure) is the commonest chronic condition in western societies, and can lead to strokes, heart attacks and kidney failure. In a disease known as primary aldosteronism (PAL), hypertension results from the excessive production of the salt-retaining hormone, aldosterone, by the the body's adrenal glands. In some patients, this is due to the growth of an aldosterone-producing adrenal tumour. Recent work performed within the Hypertension Unit at Greenslopes Hospital and continued by these investigators within the Hypertension Unit at Princess Alexandra Hospital has shown that PAL is the commonest potentially curable form of hypertension, accounting for at least 5% and possibly 10% of patients. Several lines of evidence accumulated by these investigators, including the detection of a new familial variety of PAL (Familial Hyperaldosteronism Type II or FH-II), suggest that PAL is a genetic disorder. The study sets out to locate the genetic defect causing PAL by comparing genetic material collected from affected members of these families with that from non-affected members, and by comparing genes from patients with PAL with those of unrelated, unaffected individuals. Once the genetics of this condition is understood, affected persons can be detected early in life, and even at birth, and the ill-effects of their developing conditions prevented.Read moreRead less
Improving Outcome For People With Heart Diseases Using Digital Health Technologies
Funder
National Health and Medical Research Council
Funding Amount
$606,009.00
Summary
Digital technologies such as smart phones, wearable devices, sensors and artificial intelligence have shown promise to improve human health. However, evidence that these technologies can improve health outcomes in people with heart disease is lacking. My program of research in digital health will address this need and develop new model-of-care for people with heart disease to better monitor their health, take action before their health deteriorates and provide much needed support at home.
Teachers' professional development, communities of practice, and the secondary school subject department: The case of health and physical education. Schools are significant sites of authentic learning for teacher professional development. This study will contribute to a better understanding of how the culture of the secondary school subject department can facilitate or hinder such development. The project will: contribute to creating more supportive work contexts for teachers thereby reducing te ....Teachers' professional development, communities of practice, and the secondary school subject department: The case of health and physical education. Schools are significant sites of authentic learning for teacher professional development. This study will contribute to a better understanding of how the culture of the secondary school subject department can facilitate or hinder such development. The project will: contribute to creating more supportive work contexts for teachers thereby reducing teacher attrition; inform the development of better polices and practices surrounding teachers' professional learning communities; contribute to national and state level initiatives for the articulation of professional standards for teaching; and optimise the professional practices of HPE teachers who, as 'allied health workers', are integral to addressing Australia's health priorities.Read moreRead less
Salt And Cardiovascular Disease: Does Acute Salt-Sensitivity Convey Greater Cardiovascular Risk?
Funder
National Health and Medical Research Council
Funding Amount
$597,578.00
Summary
Salt intake of Australian adults is 10X more than required. Further, salt intake in very young children is alarmingly high secondary to high consumption of salty snacks and processed food. High dietary salt intake has been associated with increased cardiovascular disease and death. We will examine the cardiovascular risks for adults and children on a high salt diet and examine whether switching to a low salt diet ameliorates the high blood pressure and heart disease caused by high salt diets
Role Of AMP-activated Protein Kinase In Salt Excretion And Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
High blood pressure is a significant health problem and may result from the kidneys not being able to get rid of salt properly. The mechanisms underlying this are unclear. I will investigate the role of a kidney protein, called AMPK, in salt excretion in mice. I will also look at the effects that diabetes and obesity have on the function of this protein. The overall aim is to improve the understanding of what causes high blood pressure which will ultimately aid the development of new treatments ....High blood pressure is a significant health problem and may result from the kidneys not being able to get rid of salt properly. The mechanisms underlying this are unclear. I will investigate the role of a kidney protein, called AMPK, in salt excretion in mice. I will also look at the effects that diabetes and obesity have on the function of this protein. The overall aim is to improve the understanding of what causes high blood pressure which will ultimately aid the development of new treatments for it.Read moreRead less
Scholarship in Science Teaching: an examination of the relationships between science content, teaching and learning. Excellent science teachers have profound impact on the students they teach. A central core of their excellence is the intertwined understandings they have of the content they teach and pedagogies for teaching this (termed pedagogical content knowledge). This knowledge is largely implicit, and hence not available to others. This research will develop enhanced methodologies to doc ....Scholarship in Science Teaching: an examination of the relationships between science content, teaching and learning. Excellent science teachers have profound impact on the students they teach. A central core of their excellence is the intertwined understandings they have of the content they teach and pedagogies for teaching this (termed pedagogical content knowledge). This knowledge is largely implicit, and hence not available to others. This research will develop enhanced methodologies to document and disseminate the knowledge of practice that underpins claims of professional excellence. Such research is crucial to the national and international moves to recognise, articulate, document, justify/validate, and share professional teaching excellence.Read moreRead less
Investigating ways to enhance teachers' science explanations and students' concept learning using cycles of reflective explanations. Explanation is central to learning because teachers explain phenomena to students and students are assessed on their explanations to other students and the teacher. Teacher explanations are not always effective and many lower secondary students provide descriptions when an explanation is needed. This projects aims for three outcomes: first, it researches teacher ....Investigating ways to enhance teachers' science explanations and students' concept learning using cycles of reflective explanations. Explanation is central to learning because teachers explain phenomena to students and students are assessed on their explanations to other students and the teacher. Teacher explanations are not always effective and many lower secondary students provide descriptions when an explanation is needed. This projects aims for three outcomes: first, it researches teacher explanations for teachers. Second, it researches student-student and student-teacher explanations to find which explanatory types maximise concept learning; and third, it evaluates a cycle of reflective explanations model for enhancing science teacher explanations.Read moreRead less
Conceptual complexity and student engagement with science in secondary school. Research demonstrates that negative student attitudes to school science are associated with the subject's difficulty and its lack of relevance to real-world experience. However, teachers who link learning to students' experience may exacerbate the difficulty of science, because real-world applications of concepts are complex. This study will initially investigate teachers' perceptions of this dilemma, and then focus ....Conceptual complexity and student engagement with science in secondary school. Research demonstrates that negative student attitudes to school science are associated with the subject's difficulty and its lack of relevance to real-world experience. However, teachers who link learning to students' experience may exacerbate the difficulty of science, because real-world applications of concepts are complex. This study will initially investigate teachers' perceptions of this dilemma, and then focus on two classrooms where teachers acknowledge the complexity involved. Using a novel conceptual framework and an innovative data collection technique the study will explore how the students? experiences of complexity shape their attitudes to science. The findings will help improve student engagement with science.Read moreRead less
The Effect of Historical-Investigative Teaching about Pendulum Motion on High School Students Understanding of the Nature of Science. This project will investigate the impact of historical investigative teaching about pendulum motion on students understanding of the nature of science - its methodology, its relationship to technology, and its interrelationship with society and culture. The project emerges from my well-reviewed book "Time for Science Education" (Kluwer,2000) that discusses the his ....The Effect of Historical-Investigative Teaching about Pendulum Motion on High School Students Understanding of the Nature of Science. This project will investigate the impact of historical investigative teaching about pendulum motion on students understanding of the nature of science - its methodology, its relationship to technology, and its interrelationship with society and culture. The project emerges from my well-reviewed book "Time for Science Education" (Kluwer,2000) that discusses the historical, methodological, technical and social aspects of the discovery of the laws of pendulum motion in the 17th Century. As the pendulum is a ubiquitous topic in primary and secondary school science programmes, the approach could make a significant contribution to raising public understanding of science.Read moreRead less
Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of ....Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of responding to the problems inherent in teaching science in the 21st century. By supporting and encouraging the creative and innovative ideas, concepts and approaches to quality science teaching and learning embedded in teachers' professional learning the development of the critical knowledge for challenging the status-quo will be advanced.Read moreRead less