Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Methylation-sensitive T Cell Genes And Childhood Food Allergy.
Funder
National Health and Medical Research Council
Funding Amount
$461,232.00
Summary
Australia has the highest reported prevalence food allergy in the world. Despite this, little is known about how allergy develops. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of food challenge proven food allergy with assessment of immune functioning & cutting edge genomics, to extensively characterise the pathways leading to food allergy in children.
Understanding The Pathogenesis And Heterogeneity Of Autoimmunity As Failure Of Multiple Steps
Funder
National Health and Medical Research Council
Funding Amount
$504,023.00
Summary
Autoimmune diseases like diabetes, thyroid disease or rheumatoid arthritis affect around 1 in 15 people in Australia. It is clear that defects in a number of different genetic mechanisms can contribute to the development of autoimmunity. But it is currently not clear how these different mechanisms need to interact to prevent the onset of disease. This grant seeks to understand these interactions and how defects in two or more tolerance mechanisms can lead to autoimmunity.
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
Discovery Early Career Researcher Award - Grant ID: DE160100569
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Ultra-Porous Devices by Synergistic Aerosol and Atomic Layer Depositions. The project aspires to develop a scalable low-cost approach for the synthesis and integration of ultra-porous films in nanodevices. The project intends to deposit atomic layers onto aerogel-like nanoparticle networks, self-assembled by thermophoresis of flame-made aerosols. This would increase the atomically-deposited layer mass by several hundred-fold per cycle and result in ultra-porous films with electrochemically activ ....Ultra-Porous Devices by Synergistic Aerosol and Atomic Layer Depositions. The project aspires to develop a scalable low-cost approach for the synthesis and integration of ultra-porous films in nanodevices. The project intends to deposit atomic layers onto aerogel-like nanoparticle networks, self-assembled by thermophoresis of flame-made aerosols. This would increase the atomically-deposited layer mass by several hundred-fold per cycle and result in ultra-porous films with electrochemically active surface areas. It is intended that the project will demonstrate the fabrication of solid–gas, solid–liquid and solid–solid nanointerfaces, which will be applicable to key emerging technologies such as wearable medical diagnostics.Read moreRead less
III-V semiconductor nanowire solar cells without p-n junctions. This project proposes a new class of nanowire solar cells that do not rely on conventional electrical (p-n) junction for photo-generated charge carrier separation. Instead the band structure of the semiconductors is engineered to form a misalignment which leads to the spatial separation of carriers. This approach is expected to fundamentally change the design of solar cells, eliminating the technologically challenging need for formi ....III-V semiconductor nanowire solar cells without p-n junctions. This project proposes a new class of nanowire solar cells that do not rely on conventional electrical (p-n) junction for photo-generated charge carrier separation. Instead the band structure of the semiconductors is engineered to form a misalignment which leads to the spatial separation of carriers. This approach is expected to fundamentally change the design of solar cells, eliminating the technologically challenging need for forming good electrical junctions, while retaining all advantages inherent to III-V semiconductor nanowire solar cells. More importantly, the device concept proposed is expected to have implications for a wider class of solar cells based on exotic/novel materials or nanostructures where achieving both n- and p-doping may be challenging.Read moreRead less
Towards high performance compound semiconductor nanowire array solar cells. Semiconductor nanowires have great potential for photovoltaic applications due to their unique structural, electrical and optical properties. This project aims to establish a new research program to integrate highly sophisticated theoretical modelling, material growth and nanofabrication capabilities to develop high performance III-V compound semiconductor nanowire array solar cells. New concepts, strategies and technolo ....Towards high performance compound semiconductor nanowire array solar cells. Semiconductor nanowires have great potential for photovoltaic applications due to their unique structural, electrical and optical properties. This project aims to establish a new research program to integrate highly sophisticated theoretical modelling, material growth and nanofabrication capabilities to develop high performance III-V compound semiconductor nanowire array solar cells. New concepts, strategies and technologies developed by this project will not only advance the fundamental understanding of many intriguing physics in nanowire materials and devices, but also pave the way towards high efficiency photovoltaics to address the world’s energy-related issues. Read moreRead less
III-V Semiconductor Nanowire Solar Cells. III-V semiconductors, proven as excellent photovoltaic materials, combined with unique properties of nanowires will be investigated as new materials for third generation high efficiency solar cells. It will lead to fundamental understanding of photovoltaic mechanisms in nanowires and demonstration of nanowire solar cells for future applications.