Design and Fabrication of Molecular Machines: the Nanomachines of the Future. Nanotechnology that incorporates the use of nanomachines and molecular machines is an exciting new area of translational research, with broad potential in biomedical technology and industrial applications. We are developing new molecular machines and optimising their assembly. Recent innovation in the world of nanotechnology concerns the design and manufacture of synthetic and hybrid machines, based on existing biologi ....Design and Fabrication of Molecular Machines: the Nanomachines of the Future. Nanotechnology that incorporates the use of nanomachines and molecular machines is an exciting new area of translational research, with broad potential in biomedical technology and industrial applications. We are developing new molecular machines and optimising their assembly. Recent innovation in the world of nanotechnology concerns the design and manufacture of synthetic and hybrid machines, based on existing biological molecular machines but incorporating synthetic parts. Australia has an opportunity to be at the forefront of these new developments in nanotechnology, with a new generation of Australian scientists being trained across the foundation disciplines of chemistry, physics and molecular biology.Read moreRead less
Indian Ocean Climate Change: Ningaloo Reef, a litmus test for the survival of coral reefs. Coral reefs are at the frontline from the effects of rapidly rising levels of carbon dioxide that is causing both global warming and oceans to become more acid-like. Our research program will determine how the survival of one of the World’s most pristine and best preserved coral reefs, Ningaloo Reef, is linked to the response of Australia’s Indian Ocean to climate change. For the first time, we will simula ....Indian Ocean Climate Change: Ningaloo Reef, a litmus test for the survival of coral reefs. Coral reefs are at the frontline from the effects of rapidly rising levels of carbon dioxide that is causing both global warming and oceans to become more acid-like. Our research program will determine how the survival of one of the World’s most pristine and best preserved coral reefs, Ningaloo Reef, is linked to the response of Australia’s Indian Ocean to climate change. For the first time, we will simulate realistic ‘future’ conditions and see how actual coral reef systems respond. This will provide a ‘yardstick’ against which the best-case survival potential of the world’s coral reefs can be assessed, critical for underpinning the urgently needed action to reduce greenhouse gas emissions if we are to ensure the survival of coral reefs.Read moreRead less
A changing climate for calcification on the Great Barrier Reef: past, present and future. The Great Barrier Reef (GBR) is a national and international icon, recognised through its inscription as a World Heritage Area and economic and social value to Australians. Maintenance of the GBR as we know it is now compromised by a rapidly changing climate. Ocean acidification, warming water temperatures and increased freshwater will progressively be detrimental to the fundamental reef-building process ....A changing climate for calcification on the Great Barrier Reef: past, present and future. The Great Barrier Reef (GBR) is a national and international icon, recognised through its inscription as a World Heritage Area and economic and social value to Australians. Maintenance of the GBR as we know it is now compromised by a rapidly changing climate. Ocean acidification, warming water temperatures and increased freshwater will progressively be detrimental to the fundamental reef-building process of calcification. Informed policy and management strategies in a rapidly changing physical environment require determination, for short and long time frames, of the regional consequences and impacts of changing reef-building capacity.Read moreRead less
Accretion and Feedback in Galaxies with Cosmic Time. Australia is a world leader in both astronomy and photonics. This proposal seeks to exploit a revolutionary device that is the first developed from the new cross-over field of astrophotonics. The Gemini Near-infrared OH Suppression IFU System (GNOSIS) instrument will showcase Australian industry development in optical fibres and will keep Australian astronomers at the forefront of international research. This will lead to major advantages wh ....Accretion and Feedback in Galaxies with Cosmic Time. Australia is a world leader in both astronomy and photonics. This proposal seeks to exploit a revolutionary device that is the first developed from the new cross-over field of astrophotonics. The Gemini Near-infrared OH Suppression IFU System (GNOSIS) instrument will showcase Australian industry development in optical fibres and will keep Australian astronomers at the forefront of international research. This will lead to major advantages when developing future instrumentation for next generation telescopes such at the Giant Magellan Telescope, enabling Australia to continue to lead astronomy and astronomical instrumentation into the next decade and beyond.Read moreRead less
Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensi ....Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensitive, selective, fast and compact.Read moreRead less
Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of m ....Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of medical conditions, from spinal cord injury through to epilepsy. Here we will demonstrate the capabilities of these novel polymer structures both in-vitro and in-vivo.Read moreRead less
A fundamental study of electronic transport in advanced semiconductor nanostructures. The principal aim of this project is to attract and retain very high calibre early career researchers by providing them with the best-available infrastructure and research environment, combined with world-class supervision and mentoring. The project brings together an outstanding team of international collaborators, who will work with the early career researchers to ensure that they are trained and mentored at ....A fundamental study of electronic transport in advanced semiconductor nanostructures. The principal aim of this project is to attract and retain very high calibre early career researchers by providing them with the best-available infrastructure and research environment, combined with world-class supervision and mentoring. The project brings together an outstanding team of international collaborators, who will work with the early career researchers to ensure that they are trained and mentored at an international level. The new science, novel characterisation methods, and theoretical models that are outcomes of this project will provide new opportunities and expertise to advance the strategic defence and national security interests of Australia, and the emerging Australian semiconductor device and solar cell industry. Read moreRead less
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. The ....Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. These materials are expected to provide benefits for Australian citizens in the energy and health sectors and contribute to the development of a robust Australian nanotechnology industry. The projects will also provide opportunities for the development of outstanding young scientists and will foster multidisciplinary collaborations.Read moreRead less
Extreme expression: building a platform for industrial plant biotechnology. Plants have remarkable potential as bioreactors for the production of usually non-plant compounds such as medical proteins, industrial proteins including enzymes and polymers. However, to realise this potential, there needs to be very significant advances in the amount of target compounds produced in the bioreactor plants and to develop other plant species as bioreactors. The aim of this project is to develop technologie ....Extreme expression: building a platform for industrial plant biotechnology. Plants have remarkable potential as bioreactors for the production of usually non-plant compounds such as medical proteins, industrial proteins including enzymes and polymers. However, to realise this potential, there needs to be very significant advances in the amount of target compounds produced in the bioreactor plants and to develop other plant species as bioreactors. The aim of this project is to develop technologies that provide the platform to produce large quantities of target novel compounds in plants and extend the range of plant species that can be used as bioreactors. These technologies will provide the basis of a dynamic biofarming industry in Australia.Read moreRead less