Regulation Of Extrinsic Death Pathways In Neutrophils
Funder
National Health and Medical Research Council
Funding Amount
$84,656.00
Summary
During infection, the lifespan of neutrophils normally increases despite an abundance of neutrophil death signals in inflamed tissues. Altered lifespan of neutrophils has been reported in diseases associated with influenza, Streptococcus, RSV and cytomegalovirus infection. Our research has discovered a relationship between the two dominant death pathways in neutrophils, indicating that alterations in one death pathway protect the neutrophil from death signals from the second death pathway.
Improving Dosing Of Common Antibiotics Used In Critically Ill Australian Indigenous Patients
Funder
National Health and Medical Research Council
Funding Amount
$98,148.00
Summary
Optimal antibiotic dosing in patients in the intensive care unit saves lives. However, the way antibiotics move through the body of an intensive care unit patient can be different to other patients. Therefore, research that identifies specific dosing for these patients is essential. Further to this, no research in an Indigenous population is available. The aim of this research is to address this gap by developing optimal antibiotic doses for Indigenous Australians in the intensive care unit.