Comprehensive characterisation of DNA demethylation pathways in vivo. This project aims to provide a better understanding of the roles that DNA methylation plays during embryonic development. DNA methylation is a major regulatory mark present in vertebrate genomes. It is well established that the genomic patterns of DNA methylation are being actively remodelled during vertebrate embryogenesis. Nevertheless, it remains unclear how these events impact gene regulation and embryonic development itse ....Comprehensive characterisation of DNA demethylation pathways in vivo. This project aims to provide a better understanding of the roles that DNA methylation plays during embryonic development. DNA methylation is a major regulatory mark present in vertebrate genomes. It is well established that the genomic patterns of DNA methylation are being actively remodelled during vertebrate embryogenesis. Nevertheless, it remains unclear how these events impact gene regulation and embryonic development itself. This project expects to unravel the functional contributions of DNA methylation to vertebrate embryogenesis by using latest cutting-edge genomics techniques. The project will be carried out on the highly tractable zebrafish model system which allows for easy genetic manipulation of the desired sequences. This project aims to provide a better understanding of embryonic development of vertebrates, including humans.Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Sex determination in dragons: Genetics, epigenetics and environment. This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how tem ....Sex determination in dragons: Genetics, epigenetics and environment. This project aims to discover the master sex-determining gene in a reptile, how that gene is differentially regulated in males and females and by temperature, and to identify evolutionary drivers of transitions between genetic and environmental sex determination. In many reptiles, like mammals, chromosomes determine sex. In others, the temperature at which their eggs are incubated determines sex. This project will study how temperature reverses chromosomal sex determination in dragon lizards. This could show how climatic extremes affect the biology of climate sensitive reptiles, and understand their vulnerability to climate change.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Measuring the impact of urban regulation on housing affordability in Australian cities and regions. Urban planning must ensure that development meets new environmental goals, but stringent regulation may reduce housing supply and affordability. This project uses new local planning data and econometric studies to quantify and monitor planning regulation impacts on housing supply and affordability in Australian cities and regions.
Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This pr ....Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This project plans to identify teacher behaviours that motivate students in their first year at secondary school. Using an experimental design with a representative sample of 150 teachers and 1500 students in low socioeconomic areas across three states, the project plans to test whether an online professional learning program for teachers can improve student engagement and achievement. This cost-effective and scalable intervention is designed for widespread dissemination to Australian teachers.Read moreRead less
Investigating literary knowledge in the making of English teachers. This project aims to create new understanding of the role of literary knowledge within subject English. English education is mandated in Australian schooling; however, subject content as well as teachers’ knowledge and pedagogical approaches are highly contested, particularly regarding the teaching of literature. Using a national survey, focus group interviews and a longitudinal study, the project aims to provide new understandi ....Investigating literary knowledge in the making of English teachers. This project aims to create new understanding of the role of literary knowledge within subject English. English education is mandated in Australian schooling; however, subject content as well as teachers’ knowledge and pedagogical approaches are highly contested, particularly regarding the teaching of literature. Using a national survey, focus group interviews and a longitudinal study, the project aims to provide new understandings of the literary knowledge that early career teachers need, of the impact of curricula and professional practice on disciplinary knowledge, and about the operation of literary studies across school and university. Significantly, it plans to use ‘literary sociability’, an innovative methodology, to generate empirical and conceptual perspectives on literary studies in Australia that will be of value internationally.Read moreRead less
Scaling global labour: the Global Union Federations in Indonesia and India. This project will generate a systematic comparison and analysis of the activities of the Global Union Federations in construction, manufacturing and plantation agriculture, in India and Indonesia. Its findings will enhance our knowledge of industrial relations in both countries, and of labour internationalism.
Ageing in a developing country and its effects on intra-household resource allocation. Indonesia, our largest neighbour and our third largest recipient of AID, is among the fastest-growing elderly populations in Southeast Asia. Ongoing cultural and economic change means that the traditional reliance of elderly on family support is breaking down leaving the country's social fabric vulnerable. Understanding the linkages between ageing, ill-health and the labour market responses at the household le ....Ageing in a developing country and its effects on intra-household resource allocation. Indonesia, our largest neighbour and our third largest recipient of AID, is among the fastest-growing elderly populations in Southeast Asia. Ongoing cultural and economic change means that the traditional reliance of elderly on family support is breaking down leaving the country's social fabric vulnerable. Understanding the linkages between ageing, ill-health and the labour market responses at the household level is the path to effectively intervene in the link between age and poverty and to successfully design policy that facilitates improvements in women's social status.Read moreRead less
The African Diaspora and Pentecostalism in Australia. This project aims to investigate the new African Diaspora in Australia and its embrace of Pentecostalism. The African community in Australia has often been associated with poor settlement outcomes, and has also been subject to racialised moral panic regarding so-called ‘African gangs.’ This project will use new methods to understand the role of Pentecostal translocal and transnational networks in supporting African communities to overcome the ....The African Diaspora and Pentecostalism in Australia. This project aims to investigate the new African Diaspora in Australia and its embrace of Pentecostalism. The African community in Australia has often been associated with poor settlement outcomes, and has also been subject to racialised moral panic regarding so-called ‘African gangs.’ This project will use new methods to understand the role of Pentecostal translocal and transnational networks in supporting African communities to overcome the challenges of settlement. The project expects to contribute to policy efforts to improve outcomes for new African arrivals in Australia.Read moreRead less