Role Of HtrA And RseP, Stress Response Proteases, In Development And Persistence Of Chlamydia Trachomatis Infections
Funder
National Health and Medical Research Council
Funding Amount
$389,984.00
Summary
This project will research the most commonly reported bacterial sexually transmitted infection Chlamydia trachomatis. Bacterial proteins which could play a role in chronic infections of humans will be investigated. Proteins will be biologically examined to determine their role during disease. This may identify proteins which could be used for diagnostic and therapeutic tools to prevent chronic Chlamydia infection (which can result in infertility and other serious conditions).
Use Of Molecular Resistance Assays To Provide Alterative Oral Treatment Strategies For Gonorrhoea In Indigenous And Other High-risk Populations; A Randomised Cluster Trial
Funder
National Health and Medical Research Council
Funding Amount
$828,671.00
Summary
Gonorrhoea has now developed resistance to almost all antibiotics that have been used to treat it. In this study, we will investigate a new treatment approach that selects antibiotics on a patient-by-patient basis. We will use new molecular assays to first test if a gonorrhoea strain infecting a patient is susceptible to an antibiotic, and will then treat on the basis of this result. By doing so, we will optimize our use of antibiotics and improve treatment strategies for gonorrhea.
Evaluation Of Chlamydia Trachomatis Treatment Failure: A Cohort Study Of Women
Funder
National Health and Medical Research Council
Funding Amount
$761,844.00
Summary
Chlamydia is a very common sexually transmissible infection in Australia that can lead to infertility in women. About 4% of young adults have it. There is increasing concern by experts about the efficacy of the recommended chlamydia treatment. This is further supported by very high repeat infection rates following a previous positive chlamydia diagnosis. This study will measure whether chlamydia treatment failure is a problem and if so, this will change treatment guidelines worldwide.
Interventions To Improve Outcomes For Young Aboriginal And Torres Strait Islander People In Sexually Transmissible Infections Blood Borne Viruses And For People Using Methamphetamines
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This ECF will enable research to be carried out in the domains of sexually transmissible infections (STI) and blood borne viruses (BBV) and specifically methamphetamine (MA) use in Aboriginal communities nationally. Specific research outcomes will be the establishment of an Aboriginal primary health care and behavioural surveillance network for STIs/BBVs in nationally dispersed clinical hubs (CRE), and an improved understanding of interventions to address MA in Aboriginal communities.
Understanding the mechanism of Wolbachia-mediated antiviral protection. Insects are involved in the transmission of many viral diseases of both plants and animals. A considerable number of these diseases have adverse effects for public health or cause large economic losses in agriculture. We were the first to discover that a common bacteria protects insects from virus infection. Knowledge of the mechanisms used by the bacteria to interfere with virus accumulation will facilitate novel strategies ....Understanding the mechanism of Wolbachia-mediated antiviral protection. Insects are involved in the transmission of many viral diseases of both plants and animals. A considerable number of these diseases have adverse effects for public health or cause large economic losses in agriculture. We were the first to discover that a common bacteria protects insects from virus infection. Knowledge of the mechanisms used by the bacteria to interfere with virus accumulation will facilitate novel strategies for control of virus disease. The findings of this project will enable Australian researchers and industry to design innovative approaches to control diseases that are transmitted by insects.Read moreRead less
Income insecurity in Australia: who is feeling the pinch and why? This project aims to measure and investigate the drivers of income insecurity in Australia. It will provide an evaluation of whether income growth is sufficient to compensate for any welfare loss due to higher income risk and the effectiveness of government taxes and transfers in alleviating income risks for different population sub-groups.
Investigation of key factors affecting the polarisation based diagnostics of power transformers. To avoid system wide power interruptions, major assets in the electricity network must be always operating satisfactorily. One of the key assets in the electricity network is the power transformer. Currently many transformers are over 50 years old and failure of a transformer may result in long interruptions in supply and the loss of millions of dollars in revenue. The ageing of transformers needs to ....Investigation of key factors affecting the polarisation based diagnostics of power transformers. To avoid system wide power interruptions, major assets in the electricity network must be always operating satisfactorily. One of the key assets in the electricity network is the power transformer. Currently many transformers are over 50 years old and failure of a transformer may result in long interruptions in supply and the loss of millions of dollars in revenue. The ageing of transformers needs to be properly monitored to avoid catastrophic failures. This project will provide an innovative solution for the better understanding of the ageing processes of transformers and help
managers make correct decisions for maintenance and replacement strategies.
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Sustainable operation of transformers with better understanding of technical and economic constraints. Transformer failure can be devastating to consumers and network service providers, costing from thousands to millions of dollars in transformer replacement and lost productivity. To avoid such catastrophic failures, the goal of this project will be to develop new methods that can maximise transformer usage and minimise cost before failure occurs.
Rapidly Locating Items in Distribution Networks with Process-Driven Nodes. Safety-critical product recalls are a major public health issue in Australia. Recent extortion attempts involving poisoning of chocolate bars, paracetamol tablets and biscuits have demonstrated the urgent need for improved ways of locating commercial products that have been released into the community. Existing product recall tools are effective only within regulated manufacturing and warehousing facilities. This project ....Rapidly Locating Items in Distribution Networks with Process-Driven Nodes. Safety-critical product recalls are a major public health issue in Australia. Recent extortion attempts involving poisoning of chocolate bars, paracetamol tablets and biscuits have demonstrated the urgent need for improved ways of locating commercial products that have been released into the community. Existing product recall tools are effective only within regulated manufacturing and warehousing facilities. This project will develop novel techniques for locating items in large-scale distribution networks driven by complex logistic processes. The outcomes of the project will make it easier to rapidly and accurately pinpoint product locations outside controlled facilities, thus contributing to both cost savings and public safety.Read moreRead less