Investigation Into The Intervention Of Arterial Thrombosis And Atherosclerosis Using Shear Sensitive Nanoparticle Drug Delivery
Funder
National Health and Medical Research Council
Funding Amount
$462,601.00
Summary
In this project we aim to provide a targeted therapy that inhibits atherosclerosis, in-stent restenosis and thrombosis; pathologies characterized by high shear stress due to a reduction in the vessel lumen. We will apply microfluidic technology to characterize lipid nano-capsules that are tagged with antibodies against activated platelets or VCAM-1, loaded with anti-platelet or immune suppressive drugs and are prone to rupture specifically under high shear stress conditions.
Investigating A Novel Role For The Haemopoietic Growth Factor Receptor, C-Mpl, In Regulating Shear-dependent Platelet Adhesive Function
Funder
National Health and Medical Research Council
Funding Amount
$570,294.00
Summary
Platelets play a critical role in blood clot formation, with low platelet numbers leading to bleeding while excessive clot formation can cause heart attack and stroke. Platelets must ‘stick’ to injured blood vessels under blood flow (shear). We have discovered that the growth factor, c-Mpl, can regulate shear-dependent platelet sticking by controlling receptor ‘shedding’ from the cell surface. We will investigate how c-Mpl performs this new role, and examine platelet function in patients with my ....Platelets play a critical role in blood clot formation, with low platelet numbers leading to bleeding while excessive clot formation can cause heart attack and stroke. Platelets must ‘stick’ to injured blood vessels under blood flow (shear). We have discovered that the growth factor, c-Mpl, can regulate shear-dependent platelet sticking by controlling receptor ‘shedding’ from the cell surface. We will investigate how c-Mpl performs this new role, and examine platelet function in patients with myeloproliferative disease who have reduced c-Mpl.Read moreRead less
Consequences Of Waveform Composition For Epithelial Integrity And Homogeneous Ventilation During HFOV
Funder
National Health and Medical Research Council
Funding Amount
$409,483.00
Summary
High-frequency oscillation (HFO) delivers up to 900 breaths/minute to newborn babies. In theory, the tiny HFO breaths decrease ventilator induced lung injury whilst efficiently delivering oxygen to and removing waste gas from the blood. However, HFO may damage the large airways due to the high gas flows. We will use mathematical models and studies in preterm lambs to assess how to optimise distribution of fresh gas to the lung while minimising any airway damage. Our findings will help doctors tr ....High-frequency oscillation (HFO) delivers up to 900 breaths/minute to newborn babies. In theory, the tiny HFO breaths decrease ventilator induced lung injury whilst efficiently delivering oxygen to and removing waste gas from the blood. However, HFO may damage the large airways due to the high gas flows. We will use mathematical models and studies in preterm lambs to assess how to optimise distribution of fresh gas to the lung while minimising any airway damage. Our findings will help doctors treat preterm babies with lung disease.Read moreRead less