New Drugs To Counteract The Side Effects And Premature Ageing Caused By Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$577,658.00
Summary
During cancer treatment, commonly used chemotherapy drugs cause profound side effects that include pain, nausea, heart problems, hair loss and can affect almost every system in the body. Even after chemotherapy treatment has stopped, cancer survivors face an increased risk of diseases which resemble the effects of old age. We are testing newly discovered anti-ageing molecules for their ability to reduce these side effects, and drastically improve the quality of life for cancer patients.
Understanding The Mechanisms For Ameliorating/preventing Antipsychotic-induced Obesity In Early Life
Funder
National Health and Medical Research Council
Funding Amount
$576,496.00
Summary
There has been a sharp worldwide increase during the last decade in antipsychotic prescriptions (mostly “off-label”) to paediatric patients. One important issue is that antipsychotic drugs were developed for adult patients and normally have serious side-effects. This project will not only reveal the mechanisms of antipsychotic-induced obesity side-effects in youth, but will also explore intervention strategies for preventing antipsychotic-induced weight gain/obesity in paediatric patients.
Optimal Duration Of Neoadjuvant Androgen Deprivation Therapy In Localised Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$275,000.00
Summary
Each year approximately 8000 men in Australia and New Zealand develop prostate cancer which has not spread widely and which is amenable to attempted cure by surgery or radiation. Prostate cancer depends for its growth on the male hormone, testosterone, which circulates in the blood. As a result treatment which reduces testosterone level ('androgen deprivation' [AD] therapy) can produce shrinkage of prostate cancer. In fact AD has caused temporary but valued relief to millions of men with cancer ....Each year approximately 8000 men in Australia and New Zealand develop prostate cancer which has not spread widely and which is amenable to attempted cure by surgery or radiation. Prostate cancer depends for its growth on the male hormone, testosterone, which circulates in the blood. As a result treatment which reduces testosterone level ('androgen deprivation' [AD] therapy) can produce shrinkage of prostate cancer. In fact AD has caused temporary but valued relief to millions of men with cancer of the prostate that has spread throughout the body for the last five decades, worldwide. It remains uncertain however whether AD administered before surgery or radiation will benefit any of the 8000 men each year who develop localised cancer by shrinking the cancer first. In 1996 a trial involving 800 men across Australia and New Zealand commenced under the auspices of the Trans-Tasman Radiation Oncology Group (TROG) to answer the questions: 1 - Does either 3 or 6 months AD prior to radiotherapy reduce the chances of recurrence of the cancer after radiotherapy? 2 - Does such therapy reduce the volume of tissue requiring radiotherapy and hence the chances of long term side effects after radiotherapy? This grant will support collection of follow-up information from the trial and hence answers to the questions asked.Read moreRead less
Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement i ....Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement income and public pension receipt. The project will develop a new tax records-based dataset to facilitate future research on tax and welfare systems.Read moreRead less
Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for ....Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for heterogeneity in treatment responses, and the findings will be combined with a study of regulatory and administrative processes to support the ultimate goal of a legitimate, fair, cost-effective and responsive tax system.Read moreRead less
Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in ....Hydrological changes in Australia and the South Pacific. This project plans to use stalagmites from the South–West Pacific to generate continuous rainfall records for the last 2000 years. Stalagmites contain uncorrupted data that are not available in other archives, and provide unparalleled accurate chronologies. The spatial and temporal variations of the data may highlight the interplay of climate drivers, such as El Niño Southern Oscillation, and how they change the distribution of rainfall in the Pacific. This knowledge would increase our scientific understanding and enable better predictions of the recurrence of droughts and wet events in Australia.Read moreRead less
Reconstructing changes in atmospheric circulation over the mid-latitudes of the Southern Hemisphere during the past 3000 years. The climate of the mid-latitudes of the southern hemisphere is of global significance and yet past changes have proved difficult to reconstruct due to the dearth of records. Working across the Southern Ocean region using tree rings, lake sediments and ice cores, the project will produce the first comprehensive reconstruction spanning the last 3000 years.
Understanding the drivers and impacts of long-term Antarctic ice sheet change. This project will extend historical records of change and develop an understanding of the complex linkages between the climate and Antarctic ice sheet dynamics. The results will thereby assist in identifying the mechanisms of the past and future ice sheet stability and be communicated to the general public by enhancing scientific understanding.
Personal income tax reform in Australia - development of a model. This project will produce a personal income tax model that can sustain the high revenue and other expectations imposed upon it, and yet deliver enhanced equity, efficiency and simplicity. The main benefits of developing such a model include the increased legitimacy of the income tax system, with enhanced compliance outcomes and a reduction in tax avoidance and evasion. Further benefits include reduced tax administrative and compli ....Personal income tax reform in Australia - development of a model. This project will produce a personal income tax model that can sustain the high revenue and other expectations imposed upon it, and yet deliver enhanced equity, efficiency and simplicity. The main benefits of developing such a model include the increased legitimacy of the income tax system, with enhanced compliance outcomes and a reduction in tax avoidance and evasion. Further benefits include reduced tax administrative and compliance costs, increased work effort and a positive ongoing contribution to GDP.Read moreRead less