Integrating Database Technologies and Visual Analysis in Bioinformatics for Genome Data. Solving modern biological problems, especially those involving genome data, requires advanced computational and analytical methods. The huge quantities of data and escalating demands of modern biological research increasingly require the sophistication and power of object-relational database tools. Key techniques include relational data management, pattern recognition, data mining and visualization of biolog ....Integrating Database Technologies and Visual Analysis in Bioinformatics for Genome Data. Solving modern biological problems, especially those involving genome data, requires advanced computational and analytical methods. The huge quantities of data and escalating demands of modern biological research increasingly require the sophistication and power of object-relational database tools. Key techniques include relational data management, pattern recognition, data mining and visualization of biological data. In this project we will develop efficient methodologies and data structures for gathering high-quality approximations of full genomic information, and will use these innovations as the foundation to develop novel, practical tools for clustering and visualization in genomic data mining and database management.
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Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less