Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Motor Functioning In Young People With Attention Deficit Hyperactivity Disorder – Combined Type: A Three-dimensional Motion Analysis Study.
Funder
National Health and Medical Research Council
Funding Amount
$477,065.00
Summary
Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with AD ....Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with ADHD-CT.Read moreRead less
Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
Reasons and Rationality. The project explains how we assess the truth and falsehood of everyday claims about what people have reason to do. It also explains what legitimizes our practice of praising and blaming people for their success and failure at doing what we think they have reason to do. In so doing it provides a foundation for both our ordinary practice of holding people responsible, and for the more institutionalised counterpart of this ordinary practice in the law.
The Role And Underlying Mechanisms Of Constitutional Epigenetic Silencing In Cancer Predisposition
Funder
National Health and Medical Research Council
Funding Amount
$218,617.00
Summary
Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.
Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new ....Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new insights regarding distrust and intellectual vice, thus significantly advancing knowledge of the ‘dark side’ of social epistemology. Results will lead to urgently required guidance regarding the features of social networks that exacerbate or buffer against the manifestation of these vices.Read moreRead less
The Demands of Reason. We may reason well or badly, depending on whether we satisfy two kinds of demands. We must register all and only relevant considerations and we must respond correctly to them. But ‘the demands of reason’, as described in this project, remain inadequately understood. Drawing on work from philosophy, psychology, political and legal theory, and the social sciences, this project aims to investigate the nature, power and reach of reason’s demands. It aims to shed light on what ....The Demands of Reason. We may reason well or badly, depending on whether we satisfy two kinds of demands. We must register all and only relevant considerations and we must respond correctly to them. But ‘the demands of reason’, as described in this project, remain inadequately understood. Drawing on work from philosophy, psychology, political and legal theory, and the social sciences, this project aims to investigate the nature, power and reach of reason’s demands. It aims to shed light on what they are; whether they have the positive transformative power attributed to them by enlightenment thinkers; and whether they can be adduced to explain the nature and origin of other important normative demands, such as the demands of morality, prudence and law.Read moreRead less
Roles Of Impaired Apoptosis And Differentiation In Tumourigenesis And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$21,656,910.00
Summary
The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remark ....The ten scientific laboratories in this program have joined forces to investigate two ways in which tumours develop. Both are of particular interest, because they suggest new ways in which cancer might be overcome. Most of our tissues are continually renewed throughout life by production of new cells. Therefore many of the old cells in each tissue must die off to maintain the proper cell numbers. To eliminate cells that are no longer needed or have become damaged, the body has developed a remarkable cell suicide process termed apoptosis. Unfortunately, however, occasionally a random accident to the genes in one of our cells prevents the machinery for apoptosis from being turned on. In that case, the cell will not die when it should and, by continually dividing, it may eventually give rise to a cancer. Since most cancer cells still retain most of the machinery for apoptosis, however, a drug that could switch on this natural cell death machinery would provide a promising new approach to cancer therapy. Identifying and developing such drugs is one major long-term goal of this program. The other focus of our program concerns stem cells. These are rare cells with the remarkable ability to generate an entire tissue. For example, one of our laboratories has identified stem cells that can generate all the cells in the breast. The almost unlimited regenerative capacity of stem cells has a built-in danger. If a stem cell acquires the ability to proliferate excessively, it can go on to form a tumour. Indeed, many cancer researchers now suspect that rare stem cells within a tumour cause its inexorable growth. If tumour growth is maintained by stem cells, it will be essential to develop new forms of therapy that target these rare cancer stem cells rather than merely the bulk of the tumour cells. This is another key long-term goal of our program.Read moreRead less
Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spri ....Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spring-like function of the foot. It will explain a conceptually novel design allowing shoes to support our feet, whilst harnessing the energetic benefits of the foot's spring-like function. This research has the potential to revolutionise athletic footwear design and has direct implications for enhanced performance in running athletes.Read moreRead less
Trust in a social and digital world. This project aims to provide a systematic and empirically-informed account of the way networks facilitate or hinder knowledge. Distinguishing on-line information from disinformation can be difficult. This task can be greatly assisted by networks of trusted peers, but figuring out who to trust is itself a challenge. Identifying, designing, and facilitating networks of trust is therefore an urgent task. By using the tools of social epistemology, virtue epistemo ....Trust in a social and digital world. This project aims to provide a systematic and empirically-informed account of the way networks facilitate or hinder knowledge. Distinguishing on-line information from disinformation can be difficult. This task can be greatly assisted by networks of trusted peers, but figuring out who to trust is itself a challenge. Identifying, designing, and facilitating networks of trust is therefore an urgent task. By using the tools of social epistemology, virtue epistemology, and network science, this project will identify how individuals should distribute their trust when embedded in epistemically hostile environments.Read moreRead less