Stimulant laxatives are widely used and usually very effective in the short term, but how they work is very poorly understood. Our recent work has shown that they selectively excite sensory pathways from the colon which then trigger defaecation. This points to an undiscovered mechanism that potently affects colonic sensation and motility. This is likely to be a target for new treatments for other colonic disorders such as Irritable bowel syndrome and faecal incontinence.
Looking Forward - Moving Forward Project: Transforming Systems To Improve Mental Health And Drug And Alcohol Outcomes For Aboriginal Peoples
Funder
National Health and Medical Research Council
Funding Amount
$1,304,508.00
Summary
Despite the clear need for support, Aboriginal people do not access mental health and drug and alcohol services at a level that corresponds with their need. We need to know how services can respond appropriately to this high-risk group of people. This project brings together Perth-based services, researchers and local Aboriginal Elders to implement and evaluate a framework for organisational change that will transform the way in which services respond to Aboriginal people.
Hypoxia-induced Suppression Of Respiratory Sensations And Reflexes
Funder
National Health and Medical Research Council
Funding Amount
$276,750.00
Summary
Many diseases that effect the respiratory system have their primary effect on the lungs and airway themselves but in some conditions, such as obstructive sleep apnea (OSA) and asthma, increased breathing load can induce periods of low blood oxygen which could further contribute to morbidity in these diseases. OSA is a disorder associated with snoring. Patients experience periods of sleep fragmentation and oxygen deprivation due to obstruction of the floppy portion of the upper airway (pharynx) d ....Many diseases that effect the respiratory system have their primary effect on the lungs and airway themselves but in some conditions, such as obstructive sleep apnea (OSA) and asthma, increased breathing load can induce periods of low blood oxygen which could further contribute to morbidity in these diseases. OSA is a disorder associated with snoring. Patients experience periods of sleep fragmentation and oxygen deprivation due to obstruction of the floppy portion of the upper airway (pharynx) during sleep. It affects 4% of men and 2% of women and causes excessive daytime sleepiness leading to increased risk of accidents, high blood pressure and premature cardiovascular disease. Asthma produces airway inflamation and narrowing and affects a wide range of people. Both OSA and asthma are associated with episodes of impaired breathing and reduced levels of oxygen in the blood. Low levels of oxygen in the blood (hypoxia) is well known to impair functioning of the central nervous system. We have recently found that hypoxia blunts sensations of increased breathing load in healthy people and in asthmatics. Hypoxia might therefore contribute to worsening of attacks in these diseases. This study aims to investigate how changes in blood oxygen levels affect brain processing of respiratory signals, how this translates to perception of sensations and the physiological adaptations that people make to cope with increased breathing load. We will also investigate whether the inhibitory effects of hypoxia on central nervous system function extend to other vital protective respiratory reflexes such as cough, awakening from sleep to increased breathing load and upper airway reflexes that are important for maintaining an open airway.Read moreRead less
Characterising Post Stroke Neuroplasticity In Humans – Identifying A Critical Window For Rehabilitation
Funder
National Health and Medical Research Council
Funding Amount
$764,419.00
Summary
Despite major investment in care for stroke patients, almost all have persisting disability. Stroke causes loss of brain cells that cannot be replaced. Some recovery is possible through compensatory mechanisms. In addition, intact cells around the stroke undergo growth that is critical for recovery. Animal studies suggest these changes take place in a “critical window” after stroke. Applying therapies in this window should improve outcomes. We will use novel approaches to define the “critical wi ....Despite major investment in care for stroke patients, almost all have persisting disability. Stroke causes loss of brain cells that cannot be replaced. Some recovery is possible through compensatory mechanisms. In addition, intact cells around the stroke undergo growth that is critical for recovery. Animal studies suggest these changes take place in a “critical window” after stroke. Applying therapies in this window should improve outcomes. We will use novel approaches to define the “critical window” in patients after strokeRead moreRead less
A New Clinical Tool To Assess Fitness-to-drive In Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$727,963.00
Summary
Obstructive sleep apnoea (OSA) affects 1 in 4 middle aged adults. OSA results in impaired neurobehavioral function, excessive sleepiness, and more than 2-fold increased motor vehicle crash risk and workplace accidents. However, not all patients are impaired and identifying patients at risk is a daily clinical challenge. This project proposes new and simple measures that can accurately identify patients with OSA who are most vulnerable to alertness failure and motor vehicle accident risk.
Development And Evaluation Of Novel Anti-inflammatory Products Derived From An Indigenous Medicinal Plant
Funder
National Health and Medical Research Council
Funding Amount
$276,598.00
Summary
This collaborative project between researchers at the University of South Australia and Indigenous traditional owners from Northern Kaanju homelands (Cape York Peninsula, Qld) will develop and evaluate products derived from the Northern Kaanju medicinal plant Dodonaea polyandra. Extracts of the plant and novel compounds isolated from it have anti-inflammatory activity. These have the potential to be used in inflammatory diseases such as dermatitis, arthritis and inflammatory bowel disease.
The emotional construction of self representation. This project develops and defends the novel idea that self representation is an artefact of emotional processing. The account will involve case studies of psychiatric disorder characterised by developmental or acquired problems of self representation such as depersonalisation disorder and personality disorders.
The ownership of minds. This project aims to research the awareness of a conscious state as the subject's own. This is at the heart of a perennial debate about consciousness: whether we are aware of our conscious states as our own, or are merely aware of their occurrence. The project will collaborate internationally and across disciplines and institutions to develop a conceptual distinction between two components of consciousness. It will also provide an analysis of the nature of three mental di ....The ownership of minds. This project aims to research the awareness of a conscious state as the subject's own. This is at the heart of a perennial debate about consciousness: whether we are aware of our conscious states as our own, or are merely aware of their occurrence. The project will collaborate internationally and across disciplines and institutions to develop a conceptual distinction between two components of consciousness. It will also provide an analysis of the nature of three mental disorders in which the two components seem to come apart. These outcomes are expected to constitute a significant innovation in the study of consciousness and, more generally, in the philosophy of mind.Read moreRead less
An investigation into performance characteristics of elite male and female soccer players in training and competition environments. The aim of the project is to identify critical determinants of soccer performance that will improve preparation of Australian teams for international competition. Three studies are proposed. Study One will utilize a decade of physical performance and anthropometric data on male and female soccer players at the Australian Institute of Sport to identify physical perfo ....An investigation into performance characteristics of elite male and female soccer players in training and competition environments. The aim of the project is to identify critical determinants of soccer performance that will improve preparation of Australian teams for international competition. Three studies are proposed. Study One will utilize a decade of physical performance and anthropometric data on male and female soccer players at the Australian Institute of Sport to identify physical performance standards characteristic of elite players. Study Two will comprise match analyses to delineate crucial physical, technical and tactical aspects of individual and team performance. Study three will identify characteristics specific to elite goalkeepers that may be used for monitoring responses to training and competition.Read moreRead less
The truth about false memory. This project is aimed at determining whether reports of long-forgotten episodes of sexual abuse arising during psychotherapy should be regarded as memories or not. This issue hinges on a number of conceptual questions about memory. The project will illuminate the debate on recovered memories of sexual abuse by addressing those questions.