The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less
Determining the social value of extreme, mixed-use urban developments. Using an Adelaide case study, UCity, this project will investigate the social benefit of building mixed-use vertical communities in the Australian urban context. Using an innovative Social Value Framework, the project will establish and demonstrate the multi-dimensional impacts of such developments in practice. The project utilises citizen science for real time auditing of the built environment by residents and users; smart t ....Determining the social value of extreme, mixed-use urban developments. Using an Adelaide case study, UCity, this project will investigate the social benefit of building mixed-use vertical communities in the Australian urban context. Using an innovative Social Value Framework, the project will establish and demonstrate the multi-dimensional impacts of such developments in practice. The project utilises citizen science for real time auditing of the built environment by residents and users; smart technologies for environmental and behavioural monitoring; and data analytics and design automation for spatial analysis of building use. The results will inform new models of sustainable high-rise, mixed-use buildings; providing evidence for a Social Value Framework to become a core consideration in Australian industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100174
Funder
Australian Research Council
Funding Amount
$805,000.00
Summary
Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smar ....Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smart, productive and resilient cities. These capabilities are predicated on the adoption of ISO standards, development of new ontological frameworks and an urban data dictionary to enable semantic inferencing of datasets and the development of data structures and services. This framework would then be applied to data relevant to people, land and urban infrastructure to support comparative and multi-dimensional analytics. Read moreRead less
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453630
Funder
Australian Research Council
Funding Amount
$274,692.00
Summary
High-Speed Confocal Microscope Live Cell Recording System. The high-speed confocal microscope live cell recording system we are establishing represents new generation equipment. It allows quality imaging of selected subcellular regions of live cells combined with simultaneous electrophysiological recording at rates and sensitivity hitherto not possible. This equipment provides a window of opportunity for major research advances in that it allows real-time two and three-dimensional imaging of fun ....High-Speed Confocal Microscope Live Cell Recording System. The high-speed confocal microscope live cell recording system we are establishing represents new generation equipment. It allows quality imaging of selected subcellular regions of live cells combined with simultaneous electrophysiological recording at rates and sensitivity hitherto not possible. This equipment provides a window of opportunity for major research advances in that it allows real-time two and three-dimensional imaging of fundamental cellular activities that previously could not be viewed. It will allow major advances in priority health-related research and will provide an ideal research tool to introduce young scientists and students to cutting edge research.Read moreRead less
Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization ....Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization tools and numerical models. The final outcome of the project will be a set of designs of the columns, which should be more efficient, safer and cheaper to operate, and have smaller physical and environmental footprints, thus helping the Australian LNG industry to stay globally competitive.Read moreRead less
Innovative procurement theories to optimise education per cost of school. Innovative procurement theories to optimise education per cost of school. This project aims to develop a whole-of-life procurement decision-making framework so schools can make delivering better education more cost effective. This framework—which draws on state-of-the-art and Nobel prize-winning theories and a new theory the project will develop—will be used in government and private schools. The effectiveness of this fram ....Innovative procurement theories to optimise education per cost of school. Innovative procurement theories to optimise education per cost of school. This project aims to develop a whole-of-life procurement decision-making framework so schools can make delivering better education more cost effective. This framework—which draws on state-of-the-art and Nobel prize-winning theories and a new theory the project will develop—will be used in government and private schools. The effectiveness of this framework in improving schools will be shown using a new approach to make school facilities deliver educational outcomes and account for their total production and transaction costs. This research is expected to deliver more efficient ways to future-proof schools to create a well performing school system and more resilient infrastructure vital to Australia’s future prosperity.Read moreRead less
The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Industrial Transformation Training Centres - Grant ID: IC220100030
Funder
Australian Research Council
Funding Amount
$4,978,958.00
Summary
ARC Training Centre for Next-Gen Architectural Manufacturing. The Centre will generate specialised workforce capacity within Australia’s architectural sector. Leveraging advanced architectural computing discoveries will connect architectural design with the opportunities afforded by advanced manufacturing systems. The Centre will triangulate world-leading researchers, visionary partners, and talented graduates, integrating research into practice through digital business strategies, augmented int ....ARC Training Centre for Next-Gen Architectural Manufacturing. The Centre will generate specialised workforce capacity within Australia’s architectural sector. Leveraging advanced architectural computing discoveries will connect architectural design with the opportunities afforded by advanced manufacturing systems. The Centre will triangulate world-leading researchers, visionary partners, and talented graduates, integrating research into practice through digital business strategies, augmented intelligence, and computing domains of expertise. The Centre’s program of industry-embedded PhD’s, national/international placements, short courses, and post-doctoral projects will co-develop the change agents needed to transform the architectural profession to meet our nation’s immediate strategic needs.Read moreRead less