Mechanisms Of Induction And Progression Of Childhood Asthma: Investigations In A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$517,586.00
Summary
This project investigates how certain respiratory viral infections in very young children might predispose to developing asthma, and how inflammation in the airways in asthma might then worsen. The experimental work, which will use unique mouse models developed in the laboratories of the chief investigators, will focus on changes in genes that control the pattern of immune response to allergens and that regulate the progression of inflammation.
Towards Resolution of Franchising Conflict. Franchising is a major sector in the Australian economy with annual turnover greater than $128 billion. Some 35% of franchisors report being involved in substantial disputes with franchisees. This project will investigate the causes of conflict in franchising relationships. Benefits will include a predictive model to identify where conflict is likely to occur in franchising conditions, thereby allowing participants the opportunity to address conflic ....Towards Resolution of Franchising Conflict. Franchising is a major sector in the Australian economy with annual turnover greater than $128 billion. Some 35% of franchisors report being involved in substantial disputes with franchisees. This project will investigate the causes of conflict in franchising relationships. Benefits will include a predictive model to identify where conflict is likely to occur in franchising conditions, thereby allowing participants the opportunity to address conflict before it escalates into dispute. Case studies and recommendations will inform participants and regulatory authorities so as to prevent conflict escalating. This will create a more 'level playing field' for participants and improve financial security for all stakeholders.Read moreRead less
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
RNAi Therapeutic Intervention Of Human Viral Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$584,117.00
Summary
Human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. HMPV is emerging as a major cause of morbidity and life-threatening respiratory tract disease in infants, young children and the elderly worldwide. No treatment is currently available. The objectives of this proposal are to develop novel antiviral drugs that silence the expression of viral genes and to examine protection against the disease.