Mapping the effect of social enterprise on regional city disadvantage. This project aims to explore how social enterprises affect wellbeing and community capacity in disadvantaged areas of regional cities. Governments increasingly invest in social enterprise to benefit individuals and places. This project will use a spatial methodology to map where and how benefits are realised. To date, robust evidence about how social enterprise affects disadvantage is lacking, partly due to inadequate researc ....Mapping the effect of social enterprise on regional city disadvantage. This project aims to explore how social enterprises affect wellbeing and community capacity in disadvantaged areas of regional cities. Governments increasingly invest in social enterprise to benefit individuals and places. This project will use a spatial methodology to map where and how benefits are realised. To date, robust evidence about how social enterprise affects disadvantage is lacking, partly due to inadequate research methodology. This project expects to provide web-based design tools and applications to assist regional city communities and councils in the development of social enterprises that can help disadvantaged people and places.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Big-Picture Bioethics: policy-making and liberal democracy. We live an era of rapid growth in biotechnology generating new and difficult ethical questions that need to be tackled by bioethicists and politicians. This project goes beyond typical approaches in bioethics to explore the "big picture": how policies are generated in ethically-contentious domains. It is important to examine how the values of different stakeholders are reflected in such processes to ensure that they are in accordance wi ....Big-Picture Bioethics: policy-making and liberal democracy. We live an era of rapid growth in biotechnology generating new and difficult ethical questions that need to be tackled by bioethicists and politicians. This project goes beyond typical approaches in bioethics to explore the "big picture": how policies are generated in ethically-contentious domains. It is important to examine how the values of different stakeholders are reflected in such processes to ensure that they are in accordance with Australia's commitment to fostering a multicultural, pluralistic, democratic society. This project will produce practical recommendations for refining public consultation in healthcare policy-making through an examination of three relevant contentious case studies in Australia with comparison to Canada.Read moreRead less
Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
Caring for thoroughbreds: addressing social, economic and welfare issues in international horse racing. Horse racing is an economically valuable industry but visible welfare issues are challenging its future. This study addresses perceptions and the economic worth of these issues internationally. Research findings about values, and alternatives to jump racing and whipping horses, will help change the conduct of horse racing around the world.
Quantifying sea-level trends and extremes along Australia's coastal margin. Multi-decadal changes in sea-level, and sea-level extremes, cannot be well quantified along most global coastlines, including Australia's, because the high spatial variability of sea-level is under-sampled by the sparse set of long, high quality tide gauge records. Satellite altimetry provides an alternative data source with greater spatial sampling, yet experiences contamination from land within tens of kilometres from ....Quantifying sea-level trends and extremes along Australia's coastal margin. Multi-decadal changes in sea-level, and sea-level extremes, cannot be well quantified along most global coastlines, including Australia's, because the high spatial variability of sea-level is under-sampled by the sparse set of long, high quality tide gauge records. Satellite altimetry provides an alternative data source with greater spatial sampling, yet experiences contamination from land within tens of kilometres from the coast and also suffers from regionally correlated biases. This project proposes to address these problems through re-tracking radar altimetry waveforms to derive new data in the coastal margin, enabling the production of new inferences on sea-level change and extremes at dramatically improved spatial resolution around Australia.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Vulnerability, autonomy and justice. Vulnerable people require assistance and care. But what are our responsibilities in relation to the vulnerable? And how can we provide assistance and care while avoiding stereotyping or paternalism? This research will advance ethical theory and be useful in solving practical problems in health research and policy.
Southern Ocean Sea Ice – what happened and what happens next? This project will adress our lack of confidence in future projections of sea ice around Antarctica by elucidating the mechanisms controlling sea ice in the Southern Ocean.
There is low confidence is current sea ice projections, limiting our ability to predict ice shelf melt and sea level rise.
This project will lead to a detailed understanding of the future of sea ice in the Southern Ocean, improving our understanding of ocean dynam ....Southern Ocean Sea Ice – what happened and what happens next? This project will adress our lack of confidence in future projections of sea ice around Antarctica by elucidating the mechanisms controlling sea ice in the Southern Ocean.
There is low confidence is current sea ice projections, limiting our ability to predict ice shelf melt and sea level rise.
This project will lead to a detailed understanding of the future of sea ice in the Southern Ocean, improving our understanding of ocean dynamics, ice shelf melt, and sea level rise.
The results from this project will enhance projections of sea ice, and therefore also ice shelf melt and sea level rise. Improved sea level projections will aid policy decisions for coastal communities.Read moreRead less