Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Big-Picture Bioethics: policy-making and liberal democracy. We live an era of rapid growth in biotechnology generating new and difficult ethical questions that need to be tackled by bioethicists and politicians. This project goes beyond typical approaches in bioethics to explore the "big picture": how policies are generated in ethically-contentious domains. It is important to examine how the values of different stakeholders are reflected in such processes to ensure that they are in accordance wi ....Big-Picture Bioethics: policy-making and liberal democracy. We live an era of rapid growth in biotechnology generating new and difficult ethical questions that need to be tackled by bioethicists and politicians. This project goes beyond typical approaches in bioethics to explore the "big picture": how policies are generated in ethically-contentious domains. It is important to examine how the values of different stakeholders are reflected in such processes to ensure that they are in accordance with Australia's commitment to fostering a multicultural, pluralistic, democratic society. This project will produce practical recommendations for refining public consultation in healthcare policy-making through an examination of three relevant contentious case studies in Australia with comparison to Canada.Read moreRead less
Quantifying sea-level trends and extremes along Australia's coastal margin. Multi-decadal changes in sea-level, and sea-level extremes, cannot be well quantified along most global coastlines, including Australia's, because the high spatial variability of sea-level is under-sampled by the sparse set of long, high quality tide gauge records. Satellite altimetry provides an alternative data source with greater spatial sampling, yet experiences contamination from land within tens of kilometres from ....Quantifying sea-level trends and extremes along Australia's coastal margin. Multi-decadal changes in sea-level, and sea-level extremes, cannot be well quantified along most global coastlines, including Australia's, because the high spatial variability of sea-level is under-sampled by the sparse set of long, high quality tide gauge records. Satellite altimetry provides an alternative data source with greater spatial sampling, yet experiences contamination from land within tens of kilometres from the coast and also suffers from regionally correlated biases. This project proposes to address these problems through re-tracking radar altimetry waveforms to derive new data in the coastal margin, enabling the production of new inferences on sea-level change and extremes at dramatically improved spatial resolution around Australia.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
ARC Centre of Excellence for the Weather of the 21st Century. ARC Centre of Excellence for the Weather of the 21st Century. This Centre aims to determine how Australia’s weather is being reshaped by climate change. Through a fusion of innovative analyses of observations and fundamental science advances, alongside the development of ultra-high resolution climate models, the Centre looks to address climate science’s grand challenge in anticipating the likely weather patterns of a warmer world. The ....ARC Centre of Excellence for the Weather of the 21st Century. ARC Centre of Excellence for the Weather of the 21st Century. This Centre aims to determine how Australia’s weather is being reshaped by climate change. Through a fusion of innovative analyses of observations and fundamental science advances, alongside the development of ultra-high resolution climate models, the Centre looks to address climate science’s grand challenge in anticipating the likely weather patterns of a warmer world. The Centre strives to transform climate research by focussing on what matters most to making critical adaptation and mitigation decisions – weather change. The Centre aspires to provide Australia with the knowledge, technology, and human capital for robust evidence-based decision-making in response to future weather changes in our region and to harness weather as a resource.Read moreRead less
ARC Centres of Excellence for Climate System Science. Our capacity to assess the threat of climate change is undermined by an unacceptable level of uncertainty in the understanding and modelling of regional climates. The Centre will undertake world-class research targeting identified weaknesses in the physical, chemical and biological components of the climate system. We will engage and nurture graduate students and postdoctoral follows through a program of graduate training and mentoring to per ....ARC Centres of Excellence for Climate System Science. Our capacity to assess the threat of climate change is undermined by an unacceptable level of uncertainty in the understanding and modelling of regional climates. The Centre will undertake world-class research targeting identified weaknesses in the physical, chemical and biological components of the climate system. We will engage and nurture graduate students and postdoctoral follows through a program of graduate training and mentoring to permanently transform our understanding of climate systems science particularly for the Australian region. The key outcome will be a dramatic enhancement in national capacity to understand and project the scale of future regional climate change.Read moreRead less
Activating and maintaining community participation in natural and cultural resources initiatives in the Murray-Darling Basin. The project goes beyond the rhetoric of participation to discover what factors activate communities and individuals to become involved in programs and voluntary initiatives for natural resource management. It assesses the effectiveness of existing communication channels and develops new models for more effective and representative participation. It combines the National M ....Activating and maintaining community participation in natural and cultural resources initiatives in the Murray-Darling Basin. The project goes beyond the rhetoric of participation to discover what factors activate communities and individuals to become involved in programs and voluntary initiatives for natural resource management. It assesses the effectiveness of existing communication channels and develops new models for more effective and representative participation. It combines the National Museum of Australia's expertise in environmental history and public communication with the imperative of the Murray-Darling Basin Commission to improve community participation in natural resource management. The potential for harnessing communications technology to facilitate new channels for participation is assessed through carefully evaluated pilot programs.Read moreRead less
Equator to Pole: Reconstructing tropical and Antarctic climate variability over the last millennium and their impacts on southern Australian rainfall. Water resource management is one of the greatest challenges facing sustainable agriculture and urban populations across southern Australia. Key players driving catastrophic droughts in southern Australia are the tropical Indian Ocean Dipole and polar Southern Annual Mode climate systems, which affect moisture availability and transport pathways. T ....Equator to Pole: Reconstructing tropical and Antarctic climate variability over the last millennium and their impacts on southern Australian rainfall. Water resource management is one of the greatest challenges facing sustainable agriculture and urban populations across southern Australia. Key players driving catastrophic droughts in southern Australia are the tropical Indian Ocean Dipole and polar Southern Annual Mode climate systems, which affect moisture availability and transport pathways. This collaborative research project draws together a uniquely-skilled research team to develop targeted coral, ice and cave reconstructions of these climate systems and their impacts on Australian rainfall through the last millennium. This fundamental new knowledge of the drivers of Australian rainfall variability will aid improved predictability of future changes in our valuable water resources. Read moreRead less