Addressing food insecurity through participatory social enterprise. This project aims to address food insecurity by assisting vulnerable populations to participate in the development of new food businesses. The project is expected to empower individuals and communities and create new economic development opportunities. The social and economic benefits of this project includes increased access to food, greater participation in new food enterprises and an improved quality of life for vulnerable pe ....Addressing food insecurity through participatory social enterprise. This project aims to address food insecurity by assisting vulnerable populations to participate in the development of new food businesses. The project is expected to empower individuals and communities and create new economic development opportunities. The social and economic benefits of this project includes increased access to food, greater participation in new food enterprises and an improved quality of life for vulnerable people experiencing food insecurity in Australia.Read moreRead less
Social Futures & Life Pathways of Young People in Queensland: Waves 6 & 7. This project plans to extend a large longitudinal study of young people in Queensland to investigate the impact of social, political and economic changes on educational, workforce, partnering, family and housing transitions in early adulthood. The project is designed to combine large-scale survey research with in-depth qualitative interviewing to track stability and change in the values, aspirations, health and wellbeing ....Social Futures & Life Pathways of Young People in Queensland: Waves 6 & 7. This project plans to extend a large longitudinal study of young people in Queensland to investigate the impact of social, political and economic changes on educational, workforce, partnering, family and housing transitions in early adulthood. The project is designed to combine large-scale survey research with in-depth qualitative interviewing to track stability and change in the values, aspirations, health and wellbeing of a cohort of young people who were first surveyed as secondary school students a decade earlier. This aims to inform social policy by identifying factors that promote positive career, relationship, housing and health outcomes for young adults, and those which place young adults at risk of unemployment, tertiary non-completion, residential and relationship instability, and poorer mental and physical wellbeing.Read moreRead less
Women in non-traditional careers: a longitudinal study of female professionals in the mining and resources industries. This project is in line with National Research Priority, strengthening Australia's social and economic fabric, which identifies the importance of research on workforce participation. The main aim of this research is to increase the attraction, participation, development and most importantly, retention of qualified female technical staff in the Australian resource industry. Analy ....Women in non-traditional careers: a longitudinal study of female professionals in the mining and resources industries. This project is in line with National Research Priority, strengthening Australia's social and economic fabric, which identifies the importance of research on workforce participation. The main aim of this research is to increase the attraction, participation, development and most importantly, retention of qualified female technical staff in the Australian resource industry. Analysis of project outputs will directly inform policies and practices to redress the significant skill shortages in the industry. Furthermore enhancing workplace diversity is necessary to create effective and innovative workplaces that reflect the diversity of the broader Australian society.Read moreRead less
Career mobility in educational markets: a sociological study of how families reconcile priorities. Family units have to reconcile career opportunities with educational opportunities, which can make decisions about moving complex. This project will survey police, health and education professionals with family responsibilities about how their families balance career opportunities in rural and remote areas, with education strategies.
New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tack ....New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tackles this problem through a combination of organic and inorganic synthesis to develop new electrochromic dyes that may be attached to mesoporous titania.Read moreRead less
Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. ....Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. Using the combined expertise of the applicants, it is proposed to stereospecifically synthesise dinuclear complexes and study their DNA binding. This will greatly assist in the development of drugs that can selectively target genes and altered DNA.Read moreRead less
Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy ....Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy (the pyridine-2-carboxaldehyde isonicotinoyl hydrazone [PCIH] analogues) which show oral activity. These chelators undergo some interesting iron catalysed oxidation chemistry and it is vital that the mechanism of this reaction be elucidated to determine whether it will be of biological significance upon administration of these compounds as iron chelators.Read moreRead less
Spotlighting biologically active Iron (Fe) chelators within cells. Anti-cancer drugs that act in ways different from traditional chemotherapeutics offer hope in evading acquired drug resistance. Previously we have studied compounds that can enter cancer cells, bind iron and halt cellular proliferation. However, there are many sources of iron in cells and we do not know from where these iron chelators acquire their iron or how these iron complexes kill cancer cells. We will tackle this problem by ....Spotlighting biologically active Iron (Fe) chelators within cells. Anti-cancer drugs that act in ways different from traditional chemotherapeutics offer hope in evading acquired drug resistance. Previously we have studied compounds that can enter cancer cells, bind iron and halt cellular proliferation. However, there are many sources of iron in cells and we do not know from where these iron chelators acquire their iron or how these iron complexes kill cancer cells. We will tackle this problem by attaching light emitting probes to known iron chelators and mapping their location within cells with high resolution fluorescence microscopy. These experiments will spotlight the cellular location of these potential drugs bound to iron for the first time, providing crucial information on their mode of action.Read moreRead less
Activating employment futures through work integration social enterprise. This project aims to understand how Australia can better include people experiencing disadvantage in employment. Social enterprises are increasingly recognised for creating work and pathways into work for those who are typically excluded. Yet, little is known about how they can scale their operations and effectively transition workers into mainstream jobs, and what can be learned from social enterprise in designing other i ....Activating employment futures through work integration social enterprise. This project aims to understand how Australia can better include people experiencing disadvantage in employment. Social enterprises are increasingly recognised for creating work and pathways into work for those who are typically excluded. Yet, little is known about how they can scale their operations and effectively transition workers into mainstream jobs, and what can be learned from social enterprise in designing other inclusive workplaces. Underpinned by a unique learning partnership, this project is expected to shed light on how decent and inclusive work through social enterprise can be grown. Project insights will contribute to more effective employment services and workplaces that increase the shared benefits of a diverse workforce.Read moreRead less
Intervalence Transfer in Dinuclear and Oligonuclear Polymetallic Assemblies. Mixed-valence compounds (such as the pigment Prussian Blue) have been known for over two centuries, and possess important conductivity, magnetic and spectral properties. Electron transfer between the elements of different valency (intervalence charge transfer, IVCT) gives rise to absorbances in the red or near-infrared region of the spectrum which provide fundamental information on the electron migration. By design of ....Intervalence Transfer in Dinuclear and Oligonuclear Polymetallic Assemblies. Mixed-valence compounds (such as the pigment Prussian Blue) have been known for over two centuries, and possess important conductivity, magnetic and spectral properties. Electron transfer between the elements of different valency (intervalence charge transfer, IVCT) gives rise to absorbances in the red or near-infrared region of the spectrum which provide fundamental information on the electron migration. By design of target di- and higher nuclearity polymetallic species, the project will study IVCT phenomena to understand electron movement, allowing rational development of applicable materials such as catalysts, light-activated devices and non-linear optical materials.Read moreRead less