Bioelectronic logic. This project aims to understand ion-electron interactions relevant to bioelectronics, and create transducing interfaces. Bioelectronics is a frontier field which aims to connect biological systems with modern electronics and so create biomedical devices. Transducing ion and electron signals using a biocompatible functional interface is difficult since ion and electron physics are different. By combining individual transducers, this project intends to demonstrate ground-break ....Bioelectronic logic. This project aims to understand ion-electron interactions relevant to bioelectronics, and create transducing interfaces. Bioelectronics is a frontier field which aims to connect biological systems with modern electronics and so create biomedical devices. Transducing ion and electron signals using a biocompatible functional interface is difficult since ion and electron physics are different. By combining individual transducers, this project intends to demonstrate ground-breaking bioelectronic logic capable of interface-level processing. The stretch goal is to test this new logic with a biological neuronal model. The project could deliver new science and interfacing elements to integrate tissue and circuitry, and demonstrate these in a real biological model.Read moreRead less
Co-oligomer amphiphiles for novel living and fixed nanomaterials. By using the Australian breakthrough Reversible Addition-Fragmentation chain Transfer (RAFT) polymerization technique to make new molecular structures, we will assemble these into nanoparticles and nanostructured materials and surface coatings with novel properties for a broad range of new technologies and applications.
Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team ....Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team recently invented the scanning helium atom microscope (SHeM), which can image surfaces non-destructively with nanoscale resolution. They will use the SHeM to determine the new fundamental physics that underpins the imaging mechanism. Outcomes include turning SHeM into a tool that materials and biological scientists can use in laboratories worldwide.Read moreRead less
A scalable, synthetic retina: signal processing in droplet systems with DNA. This project aims to design DNA-based nanotechnology for processing optical signals in synthetic biological systems. The intended outcome of this project is to develop a system for signal transduction in artificial bilayers using new DNA nanostructures. The anticipated goal of the project is to deliver: 1) light-based control of membrane protein insertion into artificial bilayers; 2) novel DNA-based pores that can trans ....A scalable, synthetic retina: signal processing in droplet systems with DNA. This project aims to design DNA-based nanotechnology for processing optical signals in synthetic biological systems. The intended outcome of this project is to develop a system for signal transduction in artificial bilayers using new DNA nanostructures. The anticipated goal of the project is to deliver: 1) light-based control of membrane protein insertion into artificial bilayers; 2) novel DNA-based pores that can transduce signals across membranes; 3) signal processing using multi-compartment biological components composed. Together, this technology allows us to use light and external signals to control biochemical pathways in synthetic systems.Read moreRead less
The geometry of genome access: lessons from HIV. Access to the cell’s nucleus, and hence its genome, is of deep scientific and commercial significance. It is controlled by a phase-separated diffusion barrier within the nuclear pore complex. Recent evidence, however, has shown that HIV can cross this barrier with its protective capsid intact, despite it being over one thousand times larger than the limit for passive transport. Combining concepts from soft-matter physics with recombinant assays, t ....The geometry of genome access: lessons from HIV. Access to the cell’s nucleus, and hence its genome, is of deep scientific and commercial significance. It is controlled by a phase-separated diffusion barrier within the nuclear pore complex. Recent evidence, however, has shown that HIV can cross this barrier with its protective capsid intact, despite it being over one thousand times larger than the limit for passive transport. Combining concepts from soft-matter physics with recombinant assays, this project aims to uncover the link between the unique geometry of HIV capsids and their ability to subvert the nucleus’ defenses. The expected outcome is a step-change in the understanding of nuclear access control, with downstream benefits to virology, bio-engineering and bio-technology.Read moreRead less
Rational design of new synthetic antifreeze molecules for cryopreservation. This project aims to synthesise new carbohydrate-based surfactants optimised for use as cryoprotectants, and to accurately measure, model and optimise their performance. The project will use state-of-the-art experimental methods and advanced phase-field modelling techniques to optimise the cryoprotectants so that they reduce osmotic stress in cells and inhibit ice crystal growth during freezing and thawing. The expected ....Rational design of new synthetic antifreeze molecules for cryopreservation. This project aims to synthesise new carbohydrate-based surfactants optimised for use as cryoprotectants, and to accurately measure, model and optimise their performance. The project will use state-of-the-art experimental methods and advanced phase-field modelling techniques to optimise the cryoprotectants so that they reduce osmotic stress in cells and inhibit ice crystal growth during freezing and thawing. The expected outcomes will be novel cryoprotectants that are easy to synthesise, non-toxic and effective, opening up new possibilities for the cryopreservation of cells, organs and possibly even whole organisms. This will have broad impact in critical applications such as long-term blood storage, reproductive technology and stem cell therapy, as well as preservation of endangered species.Read moreRead less
Three Dimensional Integrated Circuits. Pushing the boundaries of current silicon fabrication technology, this proposal will investigate the possibilities of new 3D architectures to ensure that Australia remains at the forefront of world-wide research into atomic-scale electronics. It creates an important link to the latest technologies in atomistic device modelling in the US, developed at Texas Instruments. More importantly, by anticipating the problems that electronic device manufacturers are c ....Three Dimensional Integrated Circuits. Pushing the boundaries of current silicon fabrication technology, this proposal will investigate the possibilities of new 3D architectures to ensure that Australia remains at the forefront of world-wide research into atomic-scale electronics. It creates an important link to the latest technologies in atomistic device modelling in the US, developed at Texas Instruments. More importantly, by anticipating the problems that electronic device manufacturers are currently facing, and will face over their long-term horizons, the proposed research also seeks to provide Australia with a chance to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less
Insight and understanding in Rare-Earth magnetism. Today's technologically driven society relies on magnetic materials to an extent unimaginable even as recently as 20 years ago. Rare-earth transition-metal intermetallics are among the most important magnetic materials, providing the World's strongest magnet with extensive applications. Despite these impressive technological and commercial developments numerous aspects of rare-earth magnetism remain to be developed and resolved. The two innovati ....Insight and understanding in Rare-Earth magnetism. Today's technologically driven society relies on magnetic materials to an extent unimaginable even as recently as 20 years ago. Rare-earth transition-metal intermetallics are among the most important magnetic materials, providing the World's strongest magnet with extensive applications. Despite these impressive technological and commercial developments numerous aspects of rare-earth magnetism remain to be developed and resolved. The two innovative topics we shall research are the critical interplay between the rare-earth and transition-metal sublattices in ternary compounds, enabling us to understand complex compounds, and exploration of a set of quaternary compounds we have recently discovered, thus opening new areas of rare-earth magnetism.Read moreRead less
Towards Quantum Electromechanical Devices with Semiconductor Nanowires. More importantly, semiconductor nanowires and nanorods represent a novel nanosystem being intensely researched world wide for applications in high efficiency solar cells, ultra bright light emitting diodes, single photon emitters, fast post CMOS wrap-gate field effect transistors, high efficiency thermoelectric devices and chemical sensing. The current proposal thus helps to ensure Australias forefront involvement in this qu ....Towards Quantum Electromechanical Devices with Semiconductor Nanowires. More importantly, semiconductor nanowires and nanorods represent a novel nanosystem being intensely researched world wide for applications in high efficiency solar cells, ultra bright light emitting diodes, single photon emitters, fast post CMOS wrap-gate field effect transistors, high efficiency thermoelectric devices and chemical sensing. The current proposal thus helps to ensure Australias forefront involvement in this quickly evolving and highly promising research field.Read moreRead less
Functional mesostructured materials in ionic liquids. Polymers, surfactants and nanoparticles are the building blocks from which smart soft matter is assembled. This project will replace conventional molecular solvents with ionic liquids, allowing us to precisely control molecular assembly through intermolecular forces and facilitate the production of new functional soft materials.