Smart comparison and assessment of prediction models for better health using next generation data mining. Prediction models can be used to provide early warning of events, such as adverse medical outcomes. This project will develop principles for the smart management of large collections of prediction models using data mining, enabling more timely medical interventions for Australians to live healthier and longer.
How the gut nervous system interacts with bacteria. This project aims to reveal how the enteric nervous system of the gastrointestinal (GI) tract interacts with the gut microbiota. Gut function has largely been studied without considering microbiota. The project will use genetically modified animal models, image analysis of gut motility and sequencing of gut microbes, and develop neurophysiological methods to understand gut function. Expected benefits include better understanding of mechanisms u ....How the gut nervous system interacts with bacteria. This project aims to reveal how the enteric nervous system of the gastrointestinal (GI) tract interacts with the gut microbiota. Gut function has largely been studied without considering microbiota. The project will use genetically modified animal models, image analysis of gut motility and sequencing of gut microbes, and develop neurophysiological methods to understand gut function. Expected benefits include better understanding of mechanisms underlying antibiotic resistance, risks associated with discretionary caesarean sections and the benefits of breastfeeding.Read moreRead less
Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importan ....Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importance on the regulatory function of miRNAs. Such information is critical in the future development of targeted therapeutics.Read moreRead less
Molecular evolution of a model oligomeric enzyme from bacterial extremophiles. The national benefits of this research program include insight into the sustainability of marine microorganisms that play an important role in Australia's diverse ecosystem, the development and applications of frontier technologies including high-performance computing on the world's largest supercomputer facility for life science research, and knowledge impacting on the discovery of novel antibiotics that target patho ....Molecular evolution of a model oligomeric enzyme from bacterial extremophiles. The national benefits of this research program include insight into the sustainability of marine microorganisms that play an important role in Australia's diverse ecosystem, the development and applications of frontier technologies including high-performance computing on the world's largest supercomputer facility for life science research, and knowledge impacting on the discovery of novel antibiotics that target pathogenic bacteria, like Golden Staph. This program will also train several young Australians in highly sought after skills, including bacteriology, biophysics, enzymology, molecular biology, molecular modelling, protein chemistry and structural biology. Read moreRead less
Controlling ultracold atomic gases. This project will develop ways to control the quantum state of ultracold atomic gases. These experimentally accessible systems will be used to investigate and understand a huge range of scientific phenomena from stars to superconductors, and enable critical quantum technologies that will revolutionise communications and precision measurement.
The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molec ....The systems biology of stem cells. Using new bioinformatic methods, this project aims to identify new classifiers of different stem cell populations, develop statistical models that address population heterogeneity and provide molecular predictors of the differentiation potential of stem cells. Understanding, predicting and directing the processes of differentiation are major goals in the disciplines of stem cell biology, developmental biology, tissue engineering and regenerative medicine. Molecular atlas projects have successfully revealed rules of genome output and regulation, by mining patterns that are evident across multiple cell types and datasets. By applying this philosophy to relevant, well-curated stem cell experiments, this project aims to create new methods for the integration and interrogation of smaller individual datasets. These methods should have broad utility and enable new avenues in tissue engineering.Read moreRead less
Smart Algorithms Linking Medical Image Data and Measures of Dysfunction. Losing sight has a profound affect on a person's quality of life. Advances in devices that monitor vision have not been matched by advances in computer software that analyses data from those devices. This project will combine computer science, visual neuroscience and clinical expertise to devise algorithms and build software that will vastly improve clinician's abilities to diagnose and monitor vision loss. In turn, this wi ....Smart Algorithms Linking Medical Image Data and Measures of Dysfunction. Losing sight has a profound affect on a person's quality of life. Advances in devices that monitor vision have not been matched by advances in computer software that analyses data from those devices. This project will combine computer science, visual neuroscience and clinical expertise to devise algorithms and build software that will vastly improve clinician's abilities to diagnose and monitor vision loss. In turn, this will dramatically improve the chances of those with diseases such as glaucoma to preserve their sight into old age. Furthermore, outcomes from this project will inform the development bionic eye technologies, which will assist those with eye diseases such as retinis pigmantosa and age-related macular degeneration to see.Read moreRead less
Generative Materialism: advancing design of the digital and physical. This interdisciplinary project aims to open the way for the next generation of manufacturing technologies by linking advanced computer science with the creative arts. Using innovative techniques that combine generative systems, advanced digital fabrication and the creative needs of modern design, the project seeks to boost human creativity by intelligently connecting the digital and physical processes of generative systems. Th ....Generative Materialism: advancing design of the digital and physical. This interdisciplinary project aims to open the way for the next generation of manufacturing technologies by linking advanced computer science with the creative arts. Using innovative techniques that combine generative systems, advanced digital fabrication and the creative needs of modern design, the project seeks to boost human creativity by intelligently connecting the digital and physical processes of generative systems. The outcomes will help build the next generation of digital arts software systems that assist creative and industry professionals to excel, promoting higher productivity and greater creativity vital to Australia's future creative industries. This will provide benefits such as the creation of breakthrough systems for the creative industries that elevate the role of computational generation and on-demand manufacturing in contemporary design, production and creative practice.Read moreRead less