Tracking Epidermal Clonal Evolution During Skin Cancer Induction And Progression
Funder
National Health and Medical Research Council
Funding Amount
$558,168.00
Summary
Skin cancer is the most frequent form of cancer in Australia and in many parts of the world. It is strongly connected to ultraviolet radiation from the sun. In this project, we will use our capacity to track individual cells, to observe the heterogeneity of tumours and the lesions that precede them. We will show the importance of this heterogeneity in tumour progression unveiling the limits of current therapies against skin cancer.
Susceptibility Of The Basal Layer Of Human Epidermis To UVA Oxidative Damage Due To Pheomelanin And Suboptimal DNA Repair
Funder
National Health and Medical Research Council
Funding Amount
$559,354.00
Summary
Australia has the highest incidence of skin cancer in the world. It is important to understand how sunlight causes skin cancer and the wavelengths involved in order to devise effective preventative and therapeutic strategies. Our proposal is that the cells in the skin that give rise to the most common forms of skin cancer, squamous cell carcinoma and basal cell carcinoma, are particularly vulnerable to UVA. We aim to study why this is the case and whether this vulnerability can be prevented.
Role Of Brm In Skin Tumour Progression From Benign To Malignant
Funder
National Health and Medical Research Council
Funding Amount
$457,267.00
Summary
Australia has the highest incidence of skin cancer in the world. Skin cancer is 3 times as common as all other cancers combined and continues to increase in incidence, particularly in the aging population. Skin cancer is caused by exposure to the ultraviolet radiation found in sunlight. Ultraviolet radiation causes the appearance of solar keratosis, or sunspots, benign lesions that are not particularly dangerous to human health. Some of these develop into malignant squamous cell carcinomas that ....Australia has the highest incidence of skin cancer in the world. Skin cancer is 3 times as common as all other cancers combined and continues to increase in incidence, particularly in the aging population. Skin cancer is caused by exposure to the ultraviolet radiation found in sunlight. Ultraviolet radiation causes the appearance of solar keratosis, or sunspots, benign lesions that are not particularly dangerous to human health. Some of these develop into malignant squamous cell carcinomas that can spread to other tissues and are potentially fatal. Little is known about the biological mechanisms involved in solar keratosis development into squamous cell carcinomas. We have identified the gene brm as being involved in this process. It has not previously been recognised that this gene is important for skin cancer development and therefore our preliminary studies have identified a potential new target. We will study the role of this gene in ultraviolet radiation induced skin carcinogenesis, determine whether it is mutated by ultraviolet radiation in human skin cancer, and what role in plays in some key biological processes in skin cancer development. This study will expand our understanding of malignant conversion during human skin carcinogenesis, the most prevalent human cancer in Australia.Read moreRead less
Fabrication of silicon solar cells in a Lunar-like vacuum environment. In-situ power generation on the Moon is essential for the advancement of space exploration and habitation. At present this involves transportation of solar cells to the Moon. This proposal aims to pave the way for manufacture of solar cells on the Moon from Lunar materials. Utilising the future extraction and purification of silicon, abundant in lunar regolith, the project will focus on fabrication of silicon solar cells. Thi ....Fabrication of silicon solar cells in a Lunar-like vacuum environment. In-situ power generation on the Moon is essential for the advancement of space exploration and habitation. At present this involves transportation of solar cells to the Moon. This proposal aims to pave the way for manufacture of solar cells on the Moon from Lunar materials. Utilising the future extraction and purification of silicon, abundant in lunar regolith, the project will focus on fabrication of silicon solar cells. This will provide power for: water mining, oxygen extraction, vehicles and habitats on the Moon and delivery of materials to Low Earth Orbit. The proposed research aims to develop solar cells that can be manufactured on the Moon, using materials abundant there, and techniques exploiting the natural vacuum of space.Read moreRead less
Special Research Initiatives - Grant ID: SR0354551
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the ....ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the world's renewable energy industry. An effective structure for networking and for the exchange of people, information and research results will maintain and improve Australia's position in this rapidly growing industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100812
Funder
Australian Research Council
Funding Amount
$425,888.00
Summary
Is degradation of photovoltaic modules predictable and preventable? This project aims to determine the fundamental properties of the hydrogen related defect causing degradation of commercial solar modules and develop models to predict its impact. The defect causes up to 16% power loss and is likely to affect all photovoltaics due to the universal behaviour of hydrogen in semiconductors. Through new techniques combining deuterium (heavy hydrogen) and machine learning, the key project outcomes are ....Is degradation of photovoltaic modules predictable and preventable? This project aims to determine the fundamental properties of the hydrogen related defect causing degradation of commercial solar modules and develop models to predict its impact. The defect causes up to 16% power loss and is likely to affect all photovoltaics due to the universal behaviour of hydrogen in semiconductors. Through new techniques combining deuterium (heavy hydrogen) and machine learning, the key project outcomes are new knowledge of hydrogen behaviour, mitigation of degradation and predictive models to test and forecast the future output of affected modules. This is critical for system design and reliability, manufacturer warranty terms, investor returns, consumer confidence, and ultimately mitigating the climate crisis.Read moreRead less
Innovative high-efficiency hybrid technology for commercial solar cells. The purpose of this project is to develop improved photovoltaic devices of significantly higher efficiency and lower cost than conventional screen-printed solar cells. This in turn will contribute to greatly reduced electricity costs from non fossil-fuel based sources.
Discovery Early Career Researcher Award - Grant ID: DE170100620
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Hydrogen passivation mechanisms in silicon solar cells. This project aims to understand hydrogen passivation mechanisms in silicon solar cells. Most silicon solar cells use low-quality wafers with defects that can reduce performance by >10%. Commercial devices use hydrogen to passivate defects and improve performance. Despite decades of research, these passivation mechanisms are controversial and industrial methods are ineffective. This project will investigate hydrogen charge-state control and ....Hydrogen passivation mechanisms in silicon solar cells. This project aims to understand hydrogen passivation mechanisms in silicon solar cells. Most silicon solar cells use low-quality wafers with defects that can reduce performance by >10%. Commercial devices use hydrogen to passivate defects and improve performance. Despite decades of research, these passivation mechanisms are controversial and industrial methods are ineffective. This project will investigate hydrogen charge-state control and transient hydrogenation processes, and correlate reaction rates and material properties. This should improve the understanding of hydrogen passivation mechanisms and lead to more effective hydrogenation processes that potentially reduce greenhouse gas emissions and the cost of sustainable electricity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100268
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Advanced Recombination-based Loss Analysis Methods for Solar Cells. Photovoltaic (PV) solar cells are too expensive to become a viable solution for the challenges facing humanity. Increasing solar cell efficiency can reduce the cost of PV-generated power. Improved efficiency requires the ability to identify and quantify loss mechanisms, many of which are recombination related. Thus, innovative analysis methods need to be developed to facilitate improved understanding and identification of variou ....Advanced Recombination-based Loss Analysis Methods for Solar Cells. Photovoltaic (PV) solar cells are too expensive to become a viable solution for the challenges facing humanity. Increasing solar cell efficiency can reduce the cost of PV-generated power. Improved efficiency requires the ability to identify and quantify loss mechanisms, many of which are recombination related. Thus, innovative analysis methods need to be developed to facilitate improved understanding and identification of various loss mechanisms. The project aims to investigate recombination processes that deteriorate solar cells performance, using a novel measurement system in combination with advanced simulation tools. The project aims to assist with development of advanced processes to improve device performance.Read moreRead less
Industrial High Efficiency Solar Cells. Photovoltaics is a promising candidate for sustainable energy generation, with Australia well-placed to capture the economic and environmental benefits from maintaining its strong position with this technology. Suntech, a world-leader in silicon solar cell production with US$2 billion annual revenue, will provide a “high profile” showplace for the developed patterning technology. This will enhance commercial opportunities arising from the project and confi ....Industrial High Efficiency Solar Cells. Photovoltaics is a promising candidate for sustainable energy generation, with Australia well-placed to capture the economic and environmental benefits from maintaining its strong position with this technology. Suntech, a world-leader in silicon solar cell production with US$2 billion annual revenue, will provide a “high profile” showplace for the developed patterning technology. This will enhance commercial opportunities arising from the project and confirm Australia’s reputation as a world leader in innovative photovoltaic research. This reputation attracts high-calibre professionals to Australia, stimulates local research and will provide opportunities for local manufacturing to exploit the technology developed as part of this project.Read moreRead less