Tracking Epidermal Clonal Evolution During Skin Cancer Induction And Progression
Funder
National Health and Medical Research Council
Funding Amount
$558,168.00
Summary
Skin cancer is the most frequent form of cancer in Australia and in many parts of the world. It is strongly connected to ultraviolet radiation from the sun. In this project, we will use our capacity to track individual cells, to observe the heterogeneity of tumours and the lesions that precede them. We will show the importance of this heterogeneity in tumour progression unveiling the limits of current therapies against skin cancer.
Susceptibility Of The Basal Layer Of Human Epidermis To UVA Oxidative Damage Due To Pheomelanin And Suboptimal DNA Repair
Funder
National Health and Medical Research Council
Funding Amount
$559,354.00
Summary
Australia has the highest incidence of skin cancer in the world. It is important to understand how sunlight causes skin cancer and the wavelengths involved in order to devise effective preventative and therapeutic strategies. Our proposal is that the cells in the skin that give rise to the most common forms of skin cancer, squamous cell carcinoma and basal cell carcinoma, are particularly vulnerable to UVA. We aim to study why this is the case and whether this vulnerability can be prevented.
Role Of Brm In Skin Tumour Progression From Benign To Malignant
Funder
National Health and Medical Research Council
Funding Amount
$457,267.00
Summary
Australia has the highest incidence of skin cancer in the world. Skin cancer is 3 times as common as all other cancers combined and continues to increase in incidence, particularly in the aging population. Skin cancer is caused by exposure to the ultraviolet radiation found in sunlight. Ultraviolet radiation causes the appearance of solar keratosis, or sunspots, benign lesions that are not particularly dangerous to human health. Some of these develop into malignant squamous cell carcinomas that ....Australia has the highest incidence of skin cancer in the world. Skin cancer is 3 times as common as all other cancers combined and continues to increase in incidence, particularly in the aging population. Skin cancer is caused by exposure to the ultraviolet radiation found in sunlight. Ultraviolet radiation causes the appearance of solar keratosis, or sunspots, benign lesions that are not particularly dangerous to human health. Some of these develop into malignant squamous cell carcinomas that can spread to other tissues and are potentially fatal. Little is known about the biological mechanisms involved in solar keratosis development into squamous cell carcinomas. We have identified the gene brm as being involved in this process. It has not previously been recognised that this gene is important for skin cancer development and therefore our preliminary studies have identified a potential new target. We will study the role of this gene in ultraviolet radiation induced skin carcinogenesis, determine whether it is mutated by ultraviolet radiation in human skin cancer, and what role in plays in some key biological processes in skin cancer development. This study will expand our understanding of malignant conversion during human skin carcinogenesis, the most prevalent human cancer in Australia.Read moreRead less
Efficient PV-Thermal Micro-concentrator. Australia must reduce its dependence on carbon sources for electricity, heating, and cooling. The PV-thermal hybrid micro-concentrator development will deliver a light-weight, low-profile, cost-effective system that can be installed in almost any situation, with versatile output that can deliver electricity at grid parity as well as providing water heating, space heating, industrial process heat, and solar cooling capabilities. The nation will benefit thr ....Efficient PV-Thermal Micro-concentrator. Australia must reduce its dependence on carbon sources for electricity, heating, and cooling. The PV-thermal hybrid micro-concentrator development will deliver a light-weight, low-profile, cost-effective system that can be installed in almost any situation, with versatile output that can deliver electricity at grid parity as well as providing water heating, space heating, industrial process heat, and solar cooling capabilities. The nation will benefit through enhanced energy independence, international research recognition, and reduced greenhouse gas emissions. Further, successful commercialisation of this technology will enhance Australia's research standing and provide a good royalty income that will fund future research and development.Read moreRead less
Concepts towards the next generation of dye-sensitised solar cells: tandem and plasmonic solar cells. This project aims at exploring the feasibility of novel device concepts to enhance the performance of dye-sensitised solar cells. These concepts include tandem solar cells as well as novel energy relay systems based on the ability of nanoparticles to effectively act as antenna systems that can funnel energy towards a sensitising dye molecule.
Advanced Sliver Solar Cells. The expected outcome of the proposed research is the development of second generation Sliver solar cell technology, encouraging large commercial impact, which would be of substantial benefit to Australia in terms of export income and employment. Origin Energy has committed >$60 million to the development and commercialisation of the first generation Sliver cell technology. Substantial further commercial investment is expected during scale-up for full scale manufactur ....Advanced Sliver Solar Cells. The expected outcome of the proposed research is the development of second generation Sliver solar cell technology, encouraging large commercial impact, which would be of substantial benefit to Australia in terms of export income and employment. Origin Energy has committed >$60 million to the development and commercialisation of the first generation Sliver cell technology. Substantial further commercial investment is expected during scale-up for full scale manufacturing.
Successful implementation of technology developed during the research will result in the displacement of fossil fuel technologies and corresponding greenhouse gas emissions reduction, assisting Government in its objective to make major cuts to greenhouse gas emissions.
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A 60% efficient solar microconcentrator for electricity and hot water. The aim of this project is to develop a microconcentrator for deployment on house roofs that will produce both solar hot water and solar electricity with a combined efficiency above 60%. The system will have a low profile and will be nearly invisible from the street. The system will track the sun. Concentration will be accomplished by a mixture of refraction and reflection. About 20% of the sunlight will be converted to elect ....A 60% efficient solar microconcentrator for electricity and hot water. The aim of this project is to develop a microconcentrator for deployment on house roofs that will produce both solar hot water and solar electricity with a combined efficiency above 60%. The system will have a low profile and will be nearly invisible from the street. The system will track the sun. Concentration will be accomplished by a mixture of refraction and reflection. About 20% of the sunlight will be converted to electricity using lines of tiny solar cells, with the balance being converted to heat which is removed by cooling fluid and stored in hot water tanks.Read moreRead less
Special Research Initiatives - Grant ID: SR0354551
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the ....ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the world's renewable energy industry. An effective structure for networking and for the exchange of people, information and research results will maintain and improve Australia's position in this rapidly growing industry.Read moreRead less
Innovative high-efficiency hybrid technology for commercial solar cells. The purpose of this project is to develop improved photovoltaic devices of significantly higher efficiency and lower cost than conventional screen-printed solar cells. This in turn will contribute to greatly reduced electricity costs from non fossil-fuel based sources.
Discovery Early Career Researcher Award - Grant ID: DE170100620
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Hydrogen passivation mechanisms in silicon solar cells. This project aims to understand hydrogen passivation mechanisms in silicon solar cells. Most silicon solar cells use low-quality wafers with defects that can reduce performance by >10%. Commercial devices use hydrogen to passivate defects and improve performance. Despite decades of research, these passivation mechanisms are controversial and industrial methods are ineffective. This project will investigate hydrogen charge-state control and ....Hydrogen passivation mechanisms in silicon solar cells. This project aims to understand hydrogen passivation mechanisms in silicon solar cells. Most silicon solar cells use low-quality wafers with defects that can reduce performance by >10%. Commercial devices use hydrogen to passivate defects and improve performance. Despite decades of research, these passivation mechanisms are controversial and industrial methods are ineffective. This project will investigate hydrogen charge-state control and transient hydrogenation processes, and correlate reaction rates and material properties. This should improve the understanding of hydrogen passivation mechanisms and lead to more effective hydrogenation processes that potentially reduce greenhouse gas emissions and the cost of sustainable electricity.Read moreRead less