Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100134
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Integrated photodetector array fabrication facility. Sensing is becoming a ubiquitous requirement for nearly all physical, chemical and biological research fields, and is increasingly important for Australia's national security and industry competitiveness. This proposal is aimed at building Australia's strengths in optoelectronic sensing technologies, enhancing and enabling research and technologies for innovative environmental monitoring, medical diagnostics, new technologies for mineral expl ....Integrated photodetector array fabrication facility. Sensing is becoming a ubiquitous requirement for nearly all physical, chemical and biological research fields, and is increasingly important for Australia's national security and industry competitiveness. This proposal is aimed at building Australia's strengths in optoelectronic sensing technologies, enhancing and enabling research and technologies for innovative environmental monitoring, medical diagnostics, new technologies for mineral exploration and improved evaluation of remediation of mine sites, through to the surveillance and sensing needs of customs, defence and national security. In doing so, it will enhance Australia's research profile as one of the world's leaders in the development and use of optoelectronic sensing.Read moreRead less
Imaging of properties of coherent elastic light scattering from turbid biological media. Imaging with coherent, elastically-scattered light for visualisation of thick-tissue morphology in vivo, or of cells buried deep in a turbid medium, remains a major challenge. We adopt an alternative approach of imaging of properties of light scattering based on regarding cellular tissue as a spatially-varying refractive-index continuum which encodes scattered light. We propose new methodologies to infer t ....Imaging of properties of coherent elastic light scattering from turbid biological media. Imaging with coherent, elastically-scattered light for visualisation of thick-tissue morphology in vivo, or of cells buried deep in a turbid medium, remains a major challenge. We adopt an alternative approach of imaging of properties of light scattering based on regarding cellular tissue as a spatially-varying refractive-index continuum which encodes scattered light. We propose new methodologies to infer tissue state and morphology indirectly based on phase delay, speckle, and angle-resolved scattering. We will break new ground in correlating the structure and function of in situ epithelial tissue and cells to light scattering enabling, e.g., the detection of mitosis and apoptosis in cells buried in thick, turbid media, and of cancers and precancers in vivo.Read moreRead less
Advances in optical coherence tomography. We propose to continue our research into the biomedical imaging technique of optical coherence tomography by making substantial new advances in the key areas of ultra-broad bandwidth operation, coincident confocal gate scanning, and dispersion compensation. These advances are aimed at improving resolution to the 1-5 micron range, which should allow a breakthrough to sub-cellular in vivo imaging, making visible sample histology in situ, which is currentl ....Advances in optical coherence tomography. We propose to continue our research into the biomedical imaging technique of optical coherence tomography by making substantial new advances in the key areas of ultra-broad bandwidth operation, coincident confocal gate scanning, and dispersion compensation. These advances are aimed at improving resolution to the 1-5 micron range, which should allow a breakthrough to sub-cellular in vivo imaging, making visible sample histology in situ, which is currently not possible. We also plan to make advances in the key area of scanning delay line technology by employing acousto-optics in OCT for the first time. Acousto-optics conveys advantages in no-moving-parts, scan-speed and accuracy.Read moreRead less