EGFR-directed radioimmunotherapy combined with chemotherapy and DNA repair inhibition: development towards clinical application for aggressive cancers. Pancreatic ductal adenocarcinoma (PDAC) and triple negative breast cancer (TNBC) are aggressive diseases which lack effective therapies in clinical use. A novel and curative therapy was developed against PDAC and TNBC which involves targeted radiotherapy combined with chemotherapy and DNA damage response inhibition. This project will develop a “p ....EGFR-directed radioimmunotherapy combined with chemotherapy and DNA repair inhibition: development towards clinical application for aggressive cancers. Pancreatic ductal adenocarcinoma (PDAC) and triple negative breast cancer (TNBC) are aggressive diseases which lack effective therapies in clinical use. A novel and curative therapy was developed against PDAC and TNBC which involves targeted radiotherapy combined with chemotherapy and DNA damage response inhibition. This project will develop a “preclinical data package” comprising a biological rationale and preclinical evidence of safety and efficacy that together would justify an early phase clinical trial. This package includes the choice of formulations, mechanism of action and safety studies. This development will have an immediate impact for PDAC and TNBC patients and a future impact on other EGFR-positive cancers.Read moreRead less
A Prospective Study Of Language Impairment And Recovery Following Surgery For Brain Tumours
Funder
National Health and Medical Research Council
Funding Amount
$861,342.00
Summary
This multi-site project will investigate the incidence and nature of post-operative language difficulties (aphasia) in patients following surgery for left hemisphere primary brain tumours. It will provide comprehensive data concerning risk factors for post-surgical aphasia in Australian patients, in addition to important information about the brain lesions responsible for its various clinical presentations. This information will be used to generate recommendations for clinical practice.
Industrial Transformation Research Hubs - Grant ID: IH230100011
Funder
Australian Research Council
Funding Amount
$4,955,854.00
Summary
ARC Research Hub for Value-Added Processing of Underutilised Carbon Waste. This Hub aims to advance upcycling technologies and associated regulatory and social engagement for processing underutilised carbon waste within Australia. Its anticipated goal is to deliver value-added products, and improved technology readiness levels for full exploitation of carbon wastes from agriculture, tyres and plastics. It will also train a large talent pool providing interdisciplinary knowledge and entrepreneuri ....ARC Research Hub for Value-Added Processing of Underutilised Carbon Waste. This Hub aims to advance upcycling technologies and associated regulatory and social engagement for processing underutilised carbon waste within Australia. Its anticipated goal is to deliver value-added products, and improved technology readiness levels for full exploitation of carbon wastes from agriculture, tyres and plastics. It will also train a large talent pool providing interdisciplinary knowledge and entrepreneurial skills for post-hub commercialisation. The Hub will benefit rural Australia by transforming local job markets and manufacturing capability. Ultimately, this Hub will make a significant contribution towards achieving Australia’s National Waste Action Plan goal by 2030, and a circular economy for a sustainable future. Read moreRead less
Development of novel cathodes for next generation solid oxide fuel cells. This project will provide novel cathodes to reduce the operating temperature of the Solid Oxide Fuel Cell (SOFC) as low as 500 degrees celsius. The technology may lead to widespread utilization of SOFCs, thus providing great assistance to Australia's industries in term of reducing carbon dioxide emission and easing pressure from carbon tax.
Nano-engineered catalysts for sustainable fuel production from waste . This project aims to address two major problems simultaneously-reducing the burden of non-recyclable waste currently going to landfill in Australia, and offsetting Australia’s reliance on imported diesel to support industry and transport needs. While approximately 95% of diesel consumed in Australia is imported, vast quantities of carbon-based waste ends up in landfill. Municipal Solid Waste (MSW) is a mixture of plant-based ....Nano-engineered catalysts for sustainable fuel production from waste . This project aims to address two major problems simultaneously-reducing the burden of non-recyclable waste currently going to landfill in Australia, and offsetting Australia’s reliance on imported diesel to support industry and transport needs. While approximately 95% of diesel consumed in Australia is imported, vast quantities of carbon-based waste ends up in landfill. Municipal Solid Waste (MSW) is a mixture of plant-based waste (including food, garden, paper, and wood) and fossil-fuel derived materials (plastics). Using an innovative and environmentally-sustainable catalytic process, the outcomes of this project are aimed alleviating Australia’s dependence on diesel fuel imports and better waste management solutions in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100197
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
National magnetochemical facility. New magnetic materials of the molecular or biological types are quite different to traditional metal oxide magnets widely used, for example, in recording devices. They are very important from the perspective of understanding fundamental properties at low temperatures, in high magnetic fields, or when irradiated by light, but they are also showing promise in a range of applications, such as memory devices and smart cards and in the new area of spintronics and m ....National magnetochemical facility. New magnetic materials of the molecular or biological types are quite different to traditional metal oxide magnets widely used, for example, in recording devices. They are very important from the perspective of understanding fundamental properties at low temperatures, in high magnetic fields, or when irradiated by light, but they are also showing promise in a range of applications, such as memory devices and smart cards and in the new area of spintronics and molecular computers. The magnetochemical projects described here, that require the new equipment being sought, are fundamental in nature but will provide the underpinning of future nanomagnetic materials.Read moreRead less
Functionally Graded Ultra High Perfomance Concete Structure under Flexure. This project aims to develop a novel multilayer functionally graded concrete structure that is a mixture of normal strength concrete and ultra high performance concrete with the mixing ratio varying in a layer-wise manner, offering a highly cost-effective structural design solution with significantly improved safety and durability over conventional concrete structures. The expected outcomes include the innovative design, ....Functionally Graded Ultra High Perfomance Concete Structure under Flexure. This project aims to develop a novel multilayer functionally graded concrete structure that is a mixture of normal strength concrete and ultra high performance concrete with the mixing ratio varying in a layer-wise manner, offering a highly cost-effective structural design solution with significantly improved safety and durability over conventional concrete structures. The expected outcomes include the innovative design, experimental data on the static and dynamic structural behaviour, development of reliable simulation techniques and optimal design procedures for the proposed structure with greatly reduced material costs. The project will have huge benefits to Australian civil engineering industry and national economy.
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Discovery Early Career Researcher Award - Grant ID: DE230101196
Funder
Australian Research Council
Funding Amount
$439,012.00
Summary
Data-Driven Design for 3D Printed Materials with Tailored Fracture Response. Fracture is the main source of material failure and may cause serious engineering disasters and even death. This project aims to develop a Data-Driven Design System that intelligently optimizes local materials and architectures for heterogeneous structures with desired fracture response, and enhancing their mechanical fracture properties including stiffness, strength, toughness, and failure displacement. It will open up ....Data-Driven Design for 3D Printed Materials with Tailored Fracture Response. Fracture is the main source of material failure and may cause serious engineering disasters and even death. This project aims to develop a Data-Driven Design System that intelligently optimizes local materials and architectures for heterogeneous structures with desired fracture response, and enhancing their mechanical fracture properties including stiffness, strength, toughness, and failure displacement. It will open up a new and promising research field in mechanics and data-driven science that deals with intractable inverse problems in broad engineering fields. Economic, high-performance, and customized 3D printed structural materials will be generated to benefit national corporations and enterprises and meet the high-end industry needs.Read moreRead less
Hybrid cathode for low temperature solid oxide fuel cells. This project aims to develop molten carbonate-perovskite hybrid cathode materials for low temperature solid oxide fuel cells (LT-SOFCs) possessing both high catalytic activity towards oxygen reduction reaction (ORR) and high tolerance to carbon dioxide poisoning. Carbon dioxide in air can poison nearly all the perovskite cathode materials developed for LT-SOFCs (below 600 degrees C) so far. These materials will not be practically useful ....Hybrid cathode for low temperature solid oxide fuel cells. This project aims to develop molten carbonate-perovskite hybrid cathode materials for low temperature solid oxide fuel cells (LT-SOFCs) possessing both high catalytic activity towards oxygen reduction reaction (ORR) and high tolerance to carbon dioxide poisoning. Carbon dioxide in air can poison nearly all the perovskite cathode materials developed for LT-SOFCs (below 600 degrees C) so far. These materials will not be practically useful until carbon dioxide poisoning can be prevented. This project expects to make these LT-SOFC cathode materials commercially viable, solving a problem for the widespread use of low temperature solid oxide fuel cells.Read moreRead less