Osteosarcoma is the most common tumour of bone. Recent success in targeting immune checkpoint blockers such as Programmed death-1 (PD-1) in genomically complex tumours suggests that osteosarcomas may be amenable to such strategies. We will characterise the role of the PD-1 pathway in osteosarcoma development and growth. Using preclinical mouse models we will investigate the biology of the PD-1 pathway and study its potential as a therapeutic target in advanced and resectable osteosarcoma.
Detection of infrared-biomarkers for the diagnosis and treatment of canine neoplasia. This research hopes to discover infrared-biomarkers for canine cancers using synchrotron infrared and laser light. Many dog cancers are similar to human cancers so cancerous tissues and cells from dogs make excellent models for human cancer research. This project will provide new insights and technological approaches to cancer diagnosis and treatment.
A Systematic Evaluation Of The Neurosurgical Application Of Peri-operative And Intra-operative MR Tractography In Different Paediatric Disease States
Funder
National Health and Medical Research Council
Funding Amount
$130,910.00
Summary
My research investigates changes in brain nerve fibre tracts/white matter in paediatric disease states and changes related to surgery by using nerve fibre tract imaging before, during and after surgery. It will also generate an imaging atlas to help understand white matter pathway development. It then serves as normative comparison to better understand aberrations in diseased neural pathways. The outcome will aid understanding in brain development, recovery and plasticity, and helps improve whit ....My research investigates changes in brain nerve fibre tracts/white matter in paediatric disease states and changes related to surgery by using nerve fibre tract imaging before, during and after surgery. It will also generate an imaging atlas to help understand white matter pathway development. It then serves as normative comparison to better understand aberrations in diseased neural pathways. The outcome will aid understanding in brain development, recovery and plasticity, and helps improve white matter lesion localisation.Read moreRead less
Centre For Translational Neuroscience: A Modular Platform For Translating Discovery Into Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$2,623,735.00
Summary
Clinical Centre of Research Excellence in Translational Neuroscience will provide people, pathways and resources to create a novel platform to take the outputs of Neuroscience Discovery programs though to improved patient outcomes for common brain diseases. A critical role will be to train and equip the best and brightest of the next generation of researchers to undertake internationally competitive translational neuroscience research that makes a difference to the health of our community.
Developing New Therapeutic Strategies For Brain Cancer
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
Each year, over 1,500 Australians will develop brain cancer. Unlike many cancers, it cannot be prevented by lifestyle changes. Adults with brain cancer usually die within 2 years. The overall aims of this funding are to extend patients' lives and build brain cancer research in Australia so that we have the best chance of curing this disease. The expected outcome is clinical trial of drug candidates for the most common and most deadly brain cancer, high-grade glioma.
Studying precancerous stem cells that cause T cell leukaemia. Recent research has identified abnormal stem cells that are the cause of T cell leukaemia. They are also resistant to therapeutics suggesting that they could be a cause of relapse. The aim of this project is to determine the abnormal pathways that cause these cells to become immortal and to determine new therapeutic strategies to eliminate them.
Building green roads with gasified municipal solid waste composites. This project aims to develop gasified municipal solid waste composites as a novel and green road material. This project expects to generate new knowledge on the fundamental properties of the developed waste composites when used as road subgrades and bases, through experimental study, physical modelling, numerical simulation, and field trials. Expected outcomes include understanding the mechanical behaviour of these waste compos ....Building green roads with gasified municipal solid waste composites. This project aims to develop gasified municipal solid waste composites as a novel and green road material. This project expects to generate new knowledge on the fundamental properties of the developed waste composites when used as road subgrades and bases, through experimental study, physical modelling, numerical simulation, and field trials. Expected outcomes include understanding the mechanical behaviour of these waste composites under static and cyclic loads, development of versatile constitutive models and numerical analysis tools, and determination of their optimal performance. Benefits include diversion of municipal and demolition wastes from landfills and the development of sustainable materials and technology for future roads.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH230100011
Funder
Australian Research Council
Funding Amount
$4,955,854.00
Summary
ARC Research Hub for Value-Added Processing of Underutilised Carbon Waste. This Hub aims to advance upcycling technologies and associated regulatory and social engagement for processing underutilised carbon waste within Australia. Its anticipated goal is to deliver value-added products, and improved technology readiness levels for full exploitation of carbon wastes from agriculture, tyres and plastics. It will also train a large talent pool providing interdisciplinary knowledge and entrepreneuri ....ARC Research Hub for Value-Added Processing of Underutilised Carbon Waste. This Hub aims to advance upcycling technologies and associated regulatory and social engagement for processing underutilised carbon waste within Australia. Its anticipated goal is to deliver value-added products, and improved technology readiness levels for full exploitation of carbon wastes from agriculture, tyres and plastics. It will also train a large talent pool providing interdisciplinary knowledge and entrepreneurial skills for post-hub commercialisation. The Hub will benefit rural Australia by transforming local job markets and manufacturing capability. Ultimately, this Hub will make a significant contribution towards achieving Australia’s National Waste Action Plan goal by 2030, and a circular economy for a sustainable future. Read moreRead less
Coordination networks based on carbonate and related ions. The very familiar carbonate ion will be put to use to generate a very unfamiliar family of new coordination polymers with geometries and topologies of fundamental structural significance. Carbonate's ability to bring associated metal centres into close communication may lead to unusual and possibly useful electrical, magnetic and catalytic properties. The ability to deliberately engineer specifically targeted coordination polymers with ....Coordination networks based on carbonate and related ions. The very familiar carbonate ion will be put to use to generate a very unfamiliar family of new coordination polymers with geometries and topologies of fundamental structural significance. Carbonate's ability to bring associated metal centres into close communication may lead to unusual and possibly useful electrical, magnetic and catalytic properties. The ability to deliberately engineer specifically targeted coordination polymers with predetermined properties or functions would make possible diverse applications of great practical value; the project will contribute significantly to the basis for such capabilities leading to ?designer materials? of the future.Read moreRead less