Smart affinity membranes for manufacture of high value therapeutic proteins. This project aims to develop next generation separation membranes for production of high-value proteins from serum. Through a combination of innovative chemistries, biotechnology and engineering, the project will enhance production, efficiency and resolution of membranes for separating complex mixtures, thereby contributing to broader understanding in membrane science. By establishing a strong collaborative link between ....Smart affinity membranes for manufacture of high value therapeutic proteins. This project aims to develop next generation separation membranes for production of high-value proteins from serum. Through a combination of innovative chemistries, biotechnology and engineering, the project will enhance production, efficiency and resolution of membranes for separating complex mixtures, thereby contributing to broader understanding in membrane science. By establishing a strong collaborative link between academic and industry researchers, this project has the potential to significantly value-add to existing and exciting Australian technology by enhancing the efficiency of plasma fractionation, improving isolation of large molecules from complex media and by improving the downstream manufacturing and bioprocessing pipeline. Read moreRead less
New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput anal ....New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.
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Converting Biomass into Value-Added Catalysts for Water Electrolysis. This project aims to employ agricultural waste to manufacture new highly active and stable non-precious metal catalysts for accelerating hydrogen production from water electrolysis. The project expects to generate new knowledge in the development of low-cost and sustainable catalysts for renewable hydrogen production and new technology for converting agricultural waste into value-added catalysts. The project outcomes are expec ....Converting Biomass into Value-Added Catalysts for Water Electrolysis. This project aims to employ agricultural waste to manufacture new highly active and stable non-precious metal catalysts for accelerating hydrogen production from water electrolysis. The project expects to generate new knowledge in the development of low-cost and sustainable catalysts for renewable hydrogen production and new technology for converting agricultural waste into value-added catalysts. The project outcomes are expected to benefit Australia by creating new commercial opportunities in ‘waste-to-catalyst’ conversion and generating a new pathway for managing and recycling agricultural waste, thus providing both environmental and economic benefits while contributing to a sustainable economy.Read moreRead less
A structure-based design approach to maximising targeting interactions. This project aims to build on a highly successful collaboration between the Australian biotechnology company Starpharma and Monash University, to better understand the design of next generation nanomaterials that home to specific target cells. The project seeks to capitalize on recent advances in dendrimer chemistry and protein engineering to explore the design of nanomaterials linked to engineered antibody fragments. The an ....A structure-based design approach to maximising targeting interactions. This project aims to build on a highly successful collaboration between the Australian biotechnology company Starpharma and Monash University, to better understand the design of next generation nanomaterials that home to specific target cells. The project seeks to capitalize on recent advances in dendrimer chemistry and protein engineering to explore the design of nanomaterials linked to engineered antibody fragments. The anticipated goal is attainment of exquisite, cell specific targeting affinity. Targeted nanomaterials have the potential to transform the clarity of imaging technologies; to facilitate the design of sensors and diagnostics that detect biochemical change in highly select cell populations and to revolutionise drug delivery.Read moreRead less
Elemental release and oxidant production from mixed coal mine dusts. The aim of this project is to understand the implications of physical and chemical characteristics of mixed coal mine dusts to their elemental release and oxidant production. The re-emergence of occupational lung diseases in recent years has revealed a major knowledge gap in the area of respirable particle reactivity. This research will examine the role between coal mine dust and their capacity to produce reactive oxygen specie ....Elemental release and oxidant production from mixed coal mine dusts. The aim of this project is to understand the implications of physical and chemical characteristics of mixed coal mine dusts to their elemental release and oxidant production. The re-emergence of occupational lung diseases in recent years has revealed a major knowledge gap in the area of respirable particle reactivity. This research will examine the role between coal mine dust and their capacity to produce reactive oxygen species, with the focus being on the role of physical and chemical properties of particles and how they transform with age. The findings will be used to develop screening protocols and develop novel monitoring / mitigation strategies for coal mine workers.Read moreRead less
Improved monitoring of aquatic pollutants in national water resources. Clean water is predicted to become the world’s most valuable asset during this century, necessitating the improved monitoring of Australia’s limited water resources. Using a new and integrated monitoring approach, this project expects to develop and implement novel passive sampling technologies to monitor a range of water pollutants, specifically toxic ionised organic chemicals of emerging concern. The outcomes of this projec ....Improved monitoring of aquatic pollutants in national water resources. Clean water is predicted to become the world’s most valuable asset during this century, necessitating the improved monitoring of Australia’s limited water resources. Using a new and integrated monitoring approach, this project expects to develop and implement novel passive sampling technologies to monitor a range of water pollutants, specifically toxic ionised organic chemicals of emerging concern. The outcomes of this project will create cost-effective tools to advance the detection of emerging chemicals in drinking, ground, surface and waste waters. The technology will benefit millions of Australians by safeguarding essential water resources.Read moreRead less
Advanced Fibre Interfaces in Active Water Management Systems. Flooding is a critical issue in Australia, generating considerable economic losses, including by stormwater contamination. The current project will pioneer an integrated solution for stormwater retention, while removing chemical pollutants. In collaboration with the company ROCKWOOL-Lapinus - based on a stonewool fibre platform - we will (i) design fibre coatings based on a versatile and chemically simple deposition process, (ii) inco ....Advanced Fibre Interfaces in Active Water Management Systems. Flooding is a critical issue in Australia, generating considerable economic losses, including by stormwater contamination. The current project will pioneer an integrated solution for stormwater retention, while removing chemical pollutants. In collaboration with the company ROCKWOOL-Lapinus - based on a stonewool fibre platform - we will (i) design fibre coatings based on a versatile and chemically simple deposition process, (ii) incorporate functionalities onto the fibres allowing active stormwater treatment to e.g. retain pollutants or target heavy metals and (iii) investigate these interfaces in-depth by advanced surface and interface characterisation methods to understand the fibre interface properties from nano- to macroscale.Read moreRead less
Understanding Australia by analysing wastewater during the Census 2021 . This project aims to utilise the Australian Census 2021, a unique opportunity to link exposure to chemical and biological hazards with catchment socio-demographic data via systematic wastewater analysis. The project is expected to advance our capabilities to identify emerging hazards and understand factors that affect spatiotemporal trends in hazards across Australia. Moreover, in a world first, the project aims to assess c ....Understanding Australia by analysing wastewater during the Census 2021 . This project aims to utilise the Australian Census 2021, a unique opportunity to link exposure to chemical and biological hazards with catchment socio-demographic data via systematic wastewater analysis. The project is expected to advance our capabilities to identify emerging hazards and understand factors that affect spatiotemporal trends in hazards across Australia. Moreover, in a world first, the project aims to assess chemical fate on a national level by linking sales/use with fate and release from wastewater treatment plants and assess treatment efficiency at >100 plants around Australia. The project expects to provide insight for government, wastewater managers and industry into hazards that may affect environmental and human health.Read moreRead less
Phase Change Materials for Wind and Solar Energy Storage. This project aims to develop and demonstrate new phase change materials to advance the technology of thermal energy storage. The project will focus on new materials that store thermal energy in the temperature range between 100 - 220°C that is optimal for distributed storage of solar and wind energy. The utility and economics of renewable energy sources are strongly limited by their intermittent nature and inexpensive means of storage are ....Phase Change Materials for Wind and Solar Energy Storage. This project aims to develop and demonstrate new phase change materials to advance the technology of thermal energy storage. The project will focus on new materials that store thermal energy in the temperature range between 100 - 220°C that is optimal for distributed storage of solar and wind energy. The utility and economics of renewable energy sources are strongly limited by their intermittent nature and inexpensive means of storage are urgently required. Expected outcomes of this project include a practical technology, which can be implemented at household and industry level, providing cheap energy from zero-carbon sources. The project aims to provide significant benefits to energy users and support further development of renewables.Read moreRead less
Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-spe ....Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-specific chemical exposures in Australia, and globally. Such data are critical to inform public health and chemical regulation policy, and provide clear guidance aimed at reducing exposures, to assess the effectiveness of existing regulations, and provide a framework for implementing surveys in the future.Read moreRead less