New Horizons in Diels-Alder Chemistry. Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-relate ....New Horizons in Diels-Alder Chemistry. Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-related analogues of natural compounds will be synthesised for biological evaluation.Read moreRead less
Experimental and Computational Investigations into Enantioselective Domino Sequences. This research program aims to develop more efficient methods for the chemical synthesis of organic substances: the materials that make up all known life forms, our medicines, and many designed materials. This research involves primarily the invention of new, enabling science. Specifically, we are trying to develop new and very general strategies to make organic compounds selectively and more efficiently than be ....Experimental and Computational Investigations into Enantioselective Domino Sequences. This research program aims to develop more efficient methods for the chemical synthesis of organic substances: the materials that make up all known life forms, our medicines, and many designed materials. This research involves primarily the invention of new, enabling science. Specifically, we are trying to develop new and very general strategies to make organic compounds selectively and more efficiently than before. A more efficient chemical synthesis means less waste, lower energy consumption and less environmental impact. Research of this kind is absolutely essential for the development of new medicines and materials. Australia lags behind many of the world's developed countries in this very important area of endeavour.Read moreRead less
Experimental-Computational Investigations into Diels-Alder Sequences. Organic molecules are an integral part of our world - in us, around us and, importantly, in our medicines. Chemists design experiments to make specific molecules by mixing the appropriate chemicals. Often, however, the outcome can't be predicted. We are developing ways to accurately predict these outcomes using computer modelling of chemical reactions. This will allow us to better understand reactions and make molecules more e ....Experimental-Computational Investigations into Diels-Alder Sequences. Organic molecules are an integral part of our world - in us, around us and, importantly, in our medicines. Chemists design experiments to make specific molecules by mixing the appropriate chemicals. Often, however, the outcome can't be predicted. We are developing ways to accurately predict these outcomes using computer modelling of chemical reactions. This will allow us to better understand reactions and make molecules more efficiently. Such research is the basis for the development of new pharmaceuticals. Few people in Australia are working in this area and we expect to train four to six people during the course of this project.Read moreRead less
Platform Technologies for the Regulation of Peptide Hormones. Research in the field of this application is expected to contribute to the social and economic welfare of Australians. It is anticipated that a platform of technologies will be developed, for the treatment of human and animal disorders associated with imbalances in levels of peptide hormones. This will provide better therapies to improve human and animal health. Related potential applications include the development of more effective ....Platform Technologies for the Regulation of Peptide Hormones. Research in the field of this application is expected to contribute to the social and economic welfare of Australians. It is anticipated that a platform of technologies will be developed, for the treatment of human and animal disorders associated with imbalances in levels of peptide hormones. This will provide better therapies to improve human and animal health. Related potential applications include the development of more effective insecticides. The range of new materials and protocols that will result from the research will be suitable for commercial exploitation. Particular benefit to Australians will result from the research being carried out locally, where the intellectual property and expertise will be developed and maintained.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100065
Funder
Australian Research Council
Funding Amount
$423,808.00
Summary
Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body ....Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body - even water - into visible tracers. The expected outcomes of this project include the synthesis and understanding of these catalysts which will be chemically fine-tuned to maximise their effectiveness. Potential benefits include translation to MRI applications to improve diagnosis and treatment, or chemical monitoring.Read moreRead less
Amino Acid and Peptide Radicals in Biochemistry and Synthesis. The aim of this research is to develop a better fundamental understanding of biochemical free radical reactions of peptides and proteins, particularly those involving superoxide radical anion and thiols, and peptide radicals in enzyme-catalysed reactions. Knowledge gained through this work will be used in the synthesis of physiologically active amino acids and peptides, as well as to establish ways to regulate biochemical free radic ....Amino Acid and Peptide Radicals in Biochemistry and Synthesis. The aim of this research is to develop a better fundamental understanding of biochemical free radical reactions of peptides and proteins, particularly those involving superoxide radical anion and thiols, and peptide radicals in enzyme-catalysed reactions. Knowledge gained through this work will be used in the synthesis of physiologically active amino acids and peptides, as well as to establish ways to regulate biochemical free radical processes. The ultimate goal of the research is to develop methods and pharmaceutical compounds to prevent and treat human disorders associated with these reactions, and to underpin commercial exploitation of peptide and protein biomaterials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100127
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Flow Reactor Chemical Synthesis Facility. Flow reactor chemical synthesis facility: This flow chemistry facility aims to greatly expand upon the traditional scale batch synthesis operations that are currently in use by organic, organometallic, biological and materials chemistry researchers while minimising environmental impact. The anticipated advantages of this facility are manifold and include both significantly enhanced capabilities (broader experimental/chemical space) and considerably impro ....Flow Reactor Chemical Synthesis Facility. Flow reactor chemical synthesis facility: This flow chemistry facility aims to greatly expand upon the traditional scale batch synthesis operations that are currently in use by organic, organometallic, biological and materials chemistry researchers while minimising environmental impact. The anticipated advantages of this facility are manifold and include both significantly enhanced capabilities (broader experimental/chemical space) and considerably improved safety and efficiency (no unstable intermediate accumulation, greater selectivity, cleaner products, reduced solvent requirements).Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly whe ....Elucidating the Mode of Action of Nicotinic Receptor Ligands. Changes in brain function can cause human diseases such as epilepsy, schizophrenia and Alzheimer's disease. To develop new medicines to treat these conditions we need to study how drugs act in the brain. This project will use new methods of chemistry to make drugs, which will then be tested for biological activity at important brain receptors. This will tell us which compounds are most effective as potential drugs and also exactly where they act in the brain. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989474
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Organic Synthesis and Reaction Processing Facility. Chemical synthesis is not only an important activity in its own right but one that provides compounds required in biology and physics. This enterprise is thus pivotal to many activities associated with a modern economy. Accordingly, it is vital to maintain a cutting-edge capacity in synthetic organic chemistry. The requested equipment will be assembled to create a state-of-the-art facility serving the needs of some sixty researchers engaged in ....Organic Synthesis and Reaction Processing Facility. Chemical synthesis is not only an important activity in its own right but one that provides compounds required in biology and physics. This enterprise is thus pivotal to many activities associated with a modern economy. Accordingly, it is vital to maintain a cutting-edge capacity in synthetic organic chemistry. The requested equipment will be assembled to create a state-of-the-art facility serving the needs of some sixty researchers engaged in diverse aspects of organic synthesis including those associated with the development of new antibiotics, drug delivery systems and molecular machines.Read moreRead less