Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100109
Funder
Australian Research Council
Funding Amount
$530,000.00
Summary
Small molecule X-ray molecular structure elucidation facility. X-ray diffraction plays a key role in identification and molecular characterisation. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry, amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-t ....Small molecule X-ray molecular structure elucidation facility. X-ray diffraction plays a key role in identification and molecular characterisation. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry, amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art research and training facilities for these techniques.Read moreRead less
Advancing the Metal-Organic Chemistry of the Heavy Alkaline Earth Elements. The project will open up a new area in Australian metal based chemical research, deriving high value added products from the already existing exploitation of Australia's substantial alkaline earth metal mineral resources. Internationally recognised expertise in the design and manipulation of highly reactive chemical tools will contribute breakthrough science and innovation to the growing pharmaceutical, fine chemicals an ....Advancing the Metal-Organic Chemistry of the Heavy Alkaline Earth Elements. The project will open up a new area in Australian metal based chemical research, deriving high value added products from the already existing exploitation of Australia's substantial alkaline earth metal mineral resources. Internationally recognised expertise in the design and manipulation of highly reactive chemical tools will contribute breakthrough science and innovation to the growing pharmaceutical, fine chemicals and smart materials industry, with the potential to provide nascent and established Australian companies a competitive edge in new product development. Students will be trained in the necessary skills to succeed in and expand such technically demanding area of metal based chemistry.Read moreRead less
Discovering new organic chemistry using an inorganic touch. This project aims to discover new organic chemistry by treating carbon like a metal atom. Advances in fundamental organic chemistry have been important in developing products, including medicines, plastics and television display technology. Much research activity relies on applying existing organic chemistry, but inventing genuinely new organic chemistry is more difficult. By viewing carbon as a metal, this project will try to solve imp ....Discovering new organic chemistry using an inorganic touch. This project aims to discover new organic chemistry by treating carbon like a metal atom. Advances in fundamental organic chemistry have been important in developing products, including medicines, plastics and television display technology. Much research activity relies on applying existing organic chemistry, but inventing genuinely new organic chemistry is more difficult. By viewing carbon as a metal, this project will try to solve important problems in organic chemistry that have been unresolved for decades, and synthesise valuable chemicals normally generated using expensive precious metal catalysts.Read moreRead less
Novel Synthetic Receptors for Recognition and Transport of Biologically Important Anions. Anion receptors are not currently tailored for the ‘real world’ biological environments (for example, physiological saline and membranes) in which anions perform their many critical roles. The project will design and synthesise a range of molecular receptors based on large, rigid, precisely functionalisable scaffolds, tailored specifically to complement both the shape, size and charge of target anions as we ....Novel Synthetic Receptors for Recognition and Transport of Biologically Important Anions. Anion receptors are not currently tailored for the ‘real world’ biological environments (for example, physiological saline and membranes) in which anions perform their many critical roles. The project will design and synthesise a range of molecular receptors based on large, rigid, precisely functionalisable scaffolds, tailored specifically to complement both the shape, size and charge of target anions as well as their native environment. The project will investigate the ability of these receptors to strongly bind their target anions with high selectivity in both aqueous systems and in membrane environments. This will lead to the development of innovative synthetic receptors that recognise and/or transport biological anions for use in biomedical applications.Read moreRead less
New reactivity from unusual main group compounds. This project will develop new, fundamentally important, yet unusual main group compounds and investigate their reactivity. The project will lead to important fundamental advance in main group chemistry and will form the basis for cheaper and cleaner future synthetic methodologies and technologies.
Discovery Early Career Researcher Award - Grant ID: DE130100186
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Base stabilised dicarbon as a new building block for supramolecular organometallic chemistry. Diamond, coal and graphite are the forms of carbon ("allotropes") found in everyday life. The discovery of two further allotropes of carbon, the fullerenes and graphene both led to Nobel Prize awards. We have identified a method to stabilize another form of carbon, dicarbon, and will harness its properties for the formation of new materials.
Novel hydride complexes for chemical applications. Many main group elements are abundant, cheap, generally less harmful and sometimes even biocompatible compared with most other elements from the periodic table. This project will develop a range of fundamentally important well-defined molecular s-block metal and non-metal hydride complexes and investigate their chemistry and properties. These underdeveloped but emerging compound classes are of significant importance for chemical synthesis, hydro ....Novel hydride complexes for chemical applications. Many main group elements are abundant, cheap, generally less harmful and sometimes even biocompatible compared with most other elements from the periodic table. This project will develop a range of fundamentally important well-defined molecular s-block metal and non-metal hydride complexes and investigate their chemistry and properties. These underdeveloped but emerging compound classes are of significant importance for chemical synthesis, hydrogen storage and catalysis. The results emerging from this project will contribute towards the development of greener and more sustainable technologies.Read moreRead less
Brønsted Acid Activated Chiral Brønsted Bases: Catalysts for Enantioselective Photochemical and Aminyl Radical Reactions. In coming years the Australian pharmaceutical industry will face unprecedented challenges regarding the generation of wealth in an environmentally sustainable fashion. This proposal aims to address these issues through the development of a range of organocatalytic methods, which will provide access to valuable materials in a sustainable manner. While the new technologies deri ....Brønsted Acid Activated Chiral Brønsted Bases: Catalysts for Enantioselective Photochemical and Aminyl Radical Reactions. In coming years the Australian pharmaceutical industry will face unprecedented challenges regarding the generation of wealth in an environmentally sustainable fashion. This proposal aims to address these issues through the development of a range of organocatalytic methods, which will provide access to valuable materials in a sustainable manner. While the new technologies derived from these studies will deliver general benefits in the area of chemical synthesis, more localised benefits will be achieved through the synthesis of the biologically significant Grandisine natural products, which have a possible role in the management of chronic pain.Read moreRead less
A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic ....A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic molecules of pharmaceutical importance and the training of highly skilled PhD students. This should provide significant benefits, such as increased capacity for the development of new pharmaceuticals and advanced materials.Read moreRead less
Development of a Diversity-Oriented Synthesis Platform. Genomic, proteomic and other studies of the molecular basis of disease are providing a constant stream of biomolecular targets for drug discovery. Identifying suitable drugs candidates to affect these targets centres around procuring a suitable library of compounds for screening. This application addresses some of the key issues related to the development of appropriate compound libraries for such screening programs.