Redox initiated chemistry of hydrogenase H-cluster model compounds: Biologically inspired hydrogen activation catalysts? High efficiency, low temperature, cheap hydrogen activation catalysts suitable for fuel cell applications would provide the basis for the development of environmentally benign technologies suitable for transportation and some power applications. Hydrogenase enzymes are high efficiency, low temperature, hydrogen activation catalysts and the active site of the all-iron version ....Redox initiated chemistry of hydrogenase H-cluster model compounds: Biologically inspired hydrogen activation catalysts? High efficiency, low temperature, cheap hydrogen activation catalysts suitable for fuel cell applications would provide the basis for the development of environmentally benign technologies suitable for transportation and some power applications. Hydrogenase enzymes are high efficiency, low temperature, hydrogen activation catalysts and the active site of the all-iron version of the enzyme has recently been revealed to be a remarkable, weakly protein bound, iron-sulfur-carbonyl-cyanide complex. Research into the reactions of redox activated abiological model compounds will provide insights into the molecular basis of the enzymatic reaction, potentially leading to the discovery of highly efficient, biologically inspired hydrogen activation catalysts.Read moreRead less
Static and Dynamic Forces in Colloidal and Fluid Systems. Novel research based around the Atomic Force Microscope are pursued to make ultra-sensitive measurement of forces between emulsion droplets and probe the mechanical properties of long molecules such as DNA. These studies generate basic knowledge that provides insight about emulsion stability that are of importance from the food and pharmaceutical industries to manufacturing drilling mud for oil wells. The results also provide qualitativ ....Static and Dynamic Forces in Colloidal and Fluid Systems. Novel research based around the Atomic Force Microscope are pursued to make ultra-sensitive measurement of forces between emulsion droplets and probe the mechanical properties of long molecules such as DNA. These studies generate basic knowledge that provides insight about emulsion stability that are of importance from the food and pharmaceutical industries to manufacturing drilling mud for oil wells. The results also provide qualitative and predictive information about the mechanisms that determine the interaction involving large bio-molecules such as DNA and proteins. The instrumentation created along the way has the potential to be developed into special purpose ultra-sensitive devices and sensors.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882977
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Enhanced NMR Research, Characterisation and Analysis Facility. Studying molecular species is at the heart of chemistry and biochemistry and fundamental to improving our understanding of molecular mechanisms and interactions. This becomes important for elucidating aspects of biological function, medicinal and pharmaceutical chemistry, materials science and synthetic methodology, which all underpin health and technology advances in Australia. The infrastructure will support projects involving fun ....Enhanced NMR Research, Characterisation and Analysis Facility. Studying molecular species is at the heart of chemistry and biochemistry and fundamental to improving our understanding of molecular mechanisms and interactions. This becomes important for elucidating aspects of biological function, medicinal and pharmaceutical chemistry, materials science and synthetic methodology, which all underpin health and technology advances in Australia. The infrastructure will support projects involving fundamental and strategic research spanning nanotechnology and the biological and materials sciences to industry-oriented projects.Read moreRead less
Macromolecular Self-Assembly of Amyloid Fibrils. The misfolding of proteins is a key issue in public health. Common diseases, such as Alzheimer's disease, type 2 diabetes, and heart disease are associated with protein misfolding, and have a major impact on society. The use of proteins as therapeutic drugs is now common ( e.g. as vaccines, for immune disorders) but they can be rendered ineffective or harmful by protein misfolding. Through this project, we will enhance the fundamental understandin ....Macromolecular Self-Assembly of Amyloid Fibrils. The misfolding of proteins is a key issue in public health. Common diseases, such as Alzheimer's disease, type 2 diabetes, and heart disease are associated with protein misfolding, and have a major impact on society. The use of proteins as therapeutic drugs is now common ( e.g. as vaccines, for immune disorders) but they can be rendered ineffective or harmful by protein misfolding. Through this project, we will enhance the fundamental understanding of the processes of protein assembly in solution, at solid surfaces, and under shear.
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Integration of Electrochemistry and Green Chemistry: A Roadmap for Scientific Innovation. Electrochemistry represents an enabling science in physical, chemical and life sciences. It plays a key role in fundamental studies and in Australia's industrial capacity to exploit emerging technologies. Research conducted synergistically within the ARC Centre for Green Chemistry would enable the Monash Electrochemistry Group to develop and exploit new concepts. In the national interest, the Fellowship ....Integration of Electrochemistry and Green Chemistry: A Roadmap for Scientific Innovation. Electrochemistry represents an enabling science in physical, chemical and life sciences. It plays a key role in fundamental studies and in Australia's industrial capacity to exploit emerging technologies. Research conducted synergistically within the ARC Centre for Green Chemistry would enable the Monash Electrochemistry Group to develop and exploit new concepts. In the national interest, the Fellowship would: facilitate global participation in cutting-edge science derived from electrochemical and green chemical concepts; provide commercial opportunities for new and mature chemical industries; expand postgraduate training; and promote technology exchange with Australian and international leading-edge research organisations.Read moreRead less
Fabrication and Application of Ion-Sensors Based on the Voltammetry of Nanocrystals Adhered to Electrode Surfaces. A significant need exists for the low cost determination of cations and anions in biologically (blood, urine), industrially (process streams) and environmentally (rivers, lakes) important fluids. In this project, skills in sensor design, scientific instrumentation, materials science, electrochemistry and analytical science provided by a consortium of scientists at Monash University ....Fabrication and Application of Ion-Sensors Based on the Voltammetry of Nanocrystals Adhered to Electrode Surfaces. A significant need exists for the low cost determination of cations and anions in biologically (blood, urine), industrially (process streams) and environmentally (rivers, lakes) important fluids. In this project, skills in sensor design, scientific instrumentation, materials science, electrochemistry and analytical science provided by a consortium of scientists at Monash University, the Victorian Institute for Chemical Sciences, Oxford Biosensors and Oxford University will be integrated to fabricate and develop applications of commercially viable ion-sensing systems. The principles to be utilised are based on novel forms of voltammetry of nanocrystals adhered to electrode surfaces.Read moreRead less
Large amplitude Fourier transformed voltammetry: paths towards more efficient data evaluation strategies, enhanced insights and innovation in dynamic electrochemistry. Electrochemistry represents an enabling discipline in many branches of science. The aim of this research is to integrate the collective skills of an international consortium of experts in electrochemistry, electrical engineering, computing and mathematics in order to implement a blueprint proposed for innovation in electrochemic ....Large amplitude Fourier transformed voltammetry: paths towards more efficient data evaluation strategies, enhanced insights and innovation in dynamic electrochemistry. Electrochemistry represents an enabling discipline in many branches of science. The aim of this research is to integrate the collective skills of an international consortium of experts in electrochemistry, electrical engineering, computing and mathematics in order to implement a blueprint proposed for innovation in electrochemical science. In the national interest, the project will facilitate global participation in cutting-edge science derived from electrochemical concepts, provide commercial opportunities in the area of scientific instrumentation and promote technology exchange with Australian and international leading-edge research organizations.Read moreRead less
A blueprint for an intelligent instrumental, theoretical and experimental unification of a myriad of voltammetric and related electrochemical techniques. Electrochemistry is a prominent discipline in many areas of fundamental and applied science (for example, electron transfer reactions, corrosion, sensors, photovoltaics). The aim of the research proposal is to utilise skills available at Monash University and those of a national and international consortium of experts in electrochemistry, elec ....A blueprint for an intelligent instrumental, theoretical and experimental unification of a myriad of voltammetric and related electrochemical techniques. Electrochemistry is a prominent discipline in many areas of fundamental and applied science (for example, electron transfer reactions, corrosion, sensors, photovoltaics). The aim of the research proposal is to utilise skills available at Monash University and those of a national and international consortium of experts in electrochemistry, electrical engineering, computing and mathematics to introduce a new integrated instrumental, theoretical and experimental concept that will provide a blueprint for innovation in electrochemical science. An expected outcome is that important advances relevant to Australian Industry will be achieved in the area of scientific instrumentation and in modern applications of electrochemistry.Read moreRead less
Simulation, Modelling, Prediction and Two-Dimensional Retention Database Development in Comprehensive Two-Dimensional Gas Chromatography (GC×GC). Quality of life is enhanced by the application of chromatography to many aspects of living. It is an existing technology made more powerful when used as comprehensive two-dimensional gas chromatography (GC×GC), an advanced form of GC. This project will apply new interpretation strategies to GC×GC to improve precise chemical analysis in many areas inclu ....Simulation, Modelling, Prediction and Two-Dimensional Retention Database Development in Comprehensive Two-Dimensional Gas Chromatography (GC×GC). Quality of life is enhanced by the application of chromatography to many aspects of living. It is an existing technology made more powerful when used as comprehensive two-dimensional gas chromatography (GC×GC), an advanced form of GC. This project will apply new interpretation strategies to GC×GC to improve precise chemical analysis in many areas including: measurement of 'good fats' in foods, sources of illicit drugs, allergens in perfumes, disease profiling through metabolite monitoring and the detection of performance enhancing drugs in sport. Based on this research, the science of chromatography will be advanced in Australia and throughout the world, using Australian technology and expertise.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560685
Funder
Australian Research Council
Funding Amount
$451,000.00
Summary
Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. Th ....Scanning Probe Microscopy for Bioelectrochemistry. New methods to study the fundamental properties of biological samples, in particular proteins, are continuing to advance and impact on society. We will establish a leading edge facility for high-resolution imaging of biomolecules with redox functions. This will enable the continued development of new enzyme based diagnostic tests by understanding the dynamic nature of coupled electron and molecular interactions with redox enzymes in solution. The bioelectrochemical imaging facility will be unique in Australia and establish an important cross-disciplinary approach within the international community.Read moreRead less