The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
A Supervised Exercise Programme Following Hospitalisation For Heart Failure: Does It Add To Disease Management?
Funder
National Health and Medical Research Council
Funding Amount
$730,966.00
Summary
Congestive heart failure (CHF) is a common, disabling condition. Outcomes are improved by a post-hospital disease management programme (DMP) including education, support and followup from a team of nurses, doctors and other health professionals. This study looks at whether adding a supervised exercise programme to a DMP can reduce death rates and hospital stays, and improve physical function and depression in patients with a recent hospital stay for CHF.
There is a need for a greater understanding of the complex relationship between sun exposure and the production of Vitamin D. This study will expand on the recently-completed AusD study to examine how personal, behavioural, and environmental factors impact on intra-individual seasonality in Vitamin D production. The study findings will guide the development of specific, evidence-based public health recommendation that balance the risks and benefits of sun exposure.
Benefit Of 2D-strain Surveillance In Improving Cardiovascular Outcomes In Cancer Patients Undergoing Cardiotoxic Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$2,391,979.00
Summary
Cancer survivors are susceptible to heart failure (HF) caused by heart muscle damage from chemotherapy. The current testing for this problem is based on a measure that cannot identify minor changes of cardiac function. Cardiac strain is a sensitive new marker of cardiac function which is predictive of overt dysfunction & HF. This study seeks to identify whether strain can be used to assign treatments that lead to improved cardiac function and are eventually associated with a reduction in HF.
Identification Of Germline Variation That Predicts Progression Free Survival Following Chemotherapy For Advanced Ovarian Cancer
Funder
National Health and Medical Research Council
Funding Amount
$633,156.00
Summary
Women diagnosed with ovarian cancer typically undergo surgery, followed by chemotherapy. However, the efficacy of chemotherapy varies widely, with some women responding well, whilst others are exposed to the toxic effects of a treatment that does them little good. We aim to identify the genes which explain why there are differences in response. This will lead to more individualised chemotherapy and improved outcomes for women with ovarian cancer.
Quantification issues in corporate valuation, the cost of capital, and optimal capital structure. An estimate of the firm's cost of capital is probably the most important calculation required in corporate finance. It is used as the discount rate in valuation and capital budgeting decisions and forms the basis of pricing structures for many regulated industries. Corporate finance theory has identified the key inputs used to calculate the cost of capital, but the current literature falls short o ....Quantification issues in corporate valuation, the cost of capital, and optimal capital structure. An estimate of the firm's cost of capital is probably the most important calculation required in corporate finance. It is used as the discount rate in valuation and capital budgeting decisions and forms the basis of pricing structures for many regulated industries. Corporate finance theory has identified the key inputs used to calculate the cost of capital, but the current literature falls short of precisely quantifying and measuring many of these inputs. The outcomes from this project will be a framework to quantify three key aspects of the cost of capital - the value of dividend imputation tax credits, the assessment of the optimal capital structure for the firm (in particular, the quantification of bankruptcy and agency costs associated with debt financing), and the estimation of the firm's marginal tax rate.Read moreRead less
Institutional Governance Systems and Sustainability: The Transformation of Resource Industries in the United States and Australia 1974-2004. Variations in industry performance within and across nations has resulted in renewed interest in the institutional governance systems that generate national competitive advantage and innovation. There has also been an increased focus on the impact of sustainability and environmental costs on corporations. The significance of this project to the nation and t ....Institutional Governance Systems and Sustainability: The Transformation of Resource Industries in the United States and Australia 1974-2004. Variations in industry performance within and across nations has resulted in renewed interest in the institutional governance systems that generate national competitive advantage and innovation. There has also been an increased focus on the impact of sustainability and environmental costs on corporations. The significance of this project to the nation and the community is that it develops an understanding of the role played by industry institutions in transforming corporate and industry approaches to sustainability. This study will show how industries and corporations respond to sustainability over time and the impact of these changes on major stakeholders (communities; shareholders; employees).Read moreRead less
Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to ....Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to a broad suite of environmental perturbations (temperature, nutrients, contaminants), will generate stress-response data that can be incorporated alongside eukaryotic data in environmental assessments, greatly improving the ecological relevance and reliability of risk and vulnerability assessments.Read moreRead less
Coral-associated viruses: pathogens, mutualists and agents of evolution? Corals host numerous organisms, of which viruses are the least studied. The aim of this project is to characterise the viruses associated with corals and to obtain a detailed understanding of the critical roles that viruses play in coral health, coral bleaching and adaptation of corals to climate change.