Characterisation and Development of Dynamic Supramolecular Combinatorial Libraries. The discovery of biologically active molecules, in particular drug discovery, requires the design and synthesis of host molecules that bind selectively to the biological target. Combinatorial chemistry has greatly assisted this discovery process as it allows the rapid screening of large collections of molecules. In this proposal, metal ion interactions will be used in the combinatorial library as this will grea ....Characterisation and Development of Dynamic Supramolecular Combinatorial Libraries. The discovery of biologically active molecules, in particular drug discovery, requires the design and synthesis of host molecules that bind selectively to the biological target. Combinatorial chemistry has greatly assisted this discovery process as it allows the rapid screening of large collections of molecules. In this proposal, metal ion interactions will be used in the combinatorial library as this will greatly increases the diversity of the pool of compounds to be screened for activity. Understanding how to generate and analyze these libraries has potential applications in drug screening, the discovery of new substrates, enzymes and inhibitors. Read moreRead less
Speech perception precedes, indexes, and is changed by language acquisition. What is exceptional about human infants is not their sophisticated speech perception (for animals perceive human speech similarly) but their use of speech to regulate linguistic attention and bootstrap language. Using a new validated measure, language specific speech perception (discrimination ability for native minus non-native speech sounds), we can ascertain children's distribution of resources in linguistic tasks. T ....Speech perception precedes, indexes, and is changed by language acquisition. What is exceptional about human infants is not their sophisticated speech perception (for animals perceive human speech similarly) but their use of speech to regulate linguistic attention and bootstrap language. Using a new validated measure, language specific speech perception (discrimination ability for native minus non-native speech sounds), we can ascertain children's distribution of resources in linguistic tasks. This measure will be used in conjunction with a raft of experimental psycholinguistic techniques to investigate speech perception bases of phoneme perception, tone perception, word meaning, reading, and their vestiges in adulthood, to arrive at a dynamic new conception of language development. Read moreRead less