Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links betwee ....Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.Read moreRead less
The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the ....The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the project will answer a question critical to workplace safety - how much time off between shifts is needed to be alert and safe at work? The project will also produce tools to help industry design fatigue-friendly rosters, improving the safety, productivity and general well-being of shiftworkers in Australia and overseas.Read moreRead less
From structures to systems: A hierachical approach to understanding sub-cellular components. This program will dramatically extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Au ....From structures to systems: A hierachical approach to understanding sub-cellular components. This program will dramatically extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation techniques in biomolecular systems, which are widely used within the chemical and pharmaceutical industries for modelling processes ranging from protein-drug interactions to the phase behaviour of lipids and surfactants. Read moreRead less
Special Research Initiatives - Grant ID: SR0354751
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Bio-Metals Research Network. The aim of the Bio-Metals Research Network is to connect the extensive Australian expertise in the study of metal ions in relation to the Environment, Health and Frontier Technologies. The Network is inter-disciplinary and brings together over 50 group leaders in the biological, biomedical and physical sciences. A major aim of the Network will be to provide a molecular understanding of biological and environmental processes and disease states as well as pr ....Australian Bio-Metals Research Network. The aim of the Bio-Metals Research Network is to connect the extensive Australian expertise in the study of metal ions in relation to the Environment, Health and Frontier Technologies. The Network is inter-disciplinary and brings together over 50 group leaders in the biological, biomedical and physical sciences. A major aim of the Network will be to provide a molecular understanding of biological and environmental processes and disease states as well as providing new materials for the development of new technologies. The Network will interact in research and education with Bio-Metals groups around the world and will develop collaborative funding proposalsRead moreRead less
Increasing the Efficiency of Biomolecular Simulations. This program will extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation t ....Increasing the Efficiency of Biomolecular Simulations. This program will extend the range of biomolecular systems that can be modelled with near atomistic precision. It will provide a better understanding of the structure and function of proteins involved in the regulation of membrane fusion and fission as well as shedding light on the assembly of large-scale protein-protein and protein-membrane complexes in general. The work will help place Australia at the forefront of developing simulation techniques in biomolecular systems, which are widely used within the chemical and pharmaceutical industries. It will also provide opportunities for the training and development of young Australian researchers with top European laboratories. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347727
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Computational infrastructure for high-throughput genome bioinformatics. We propose a high-performance computing and web facility for genome bioinformatics. It will provide a common software development environment in support of molecular biosciences, systems biology and complex systems modelling at the Institute for Molecular Bioscience at University of Queensland, and at Queensland University of Technology. The platform will support Australia's first genome-scale bioinformatics research website ....Computational infrastructure for high-throughput genome bioinformatics. We propose a high-performance computing and web facility for genome bioinformatics. It will provide a common software development environment in support of molecular biosciences, systems biology and complex systems modelling at the Institute for Molecular Bioscience at University of Queensland, and at Queensland University of Technology. The platform will support Australia's first genome-scale bioinformatics research website, with unique software and mirrors of the IBM Biological Pattern Discovery, UC San Diego MEME/MetaMEME/MAST, and NGI comparative genomics websites. Australian/NZ researchers will access the facility at no cost for high-throughput use of unique software, website mirrors and other important tools for genome bioinformatics.Read moreRead less
Bioinformatics network for the interrogation of adult stem cells. This project addresses the National Research Priority 'Frontier Technologies for Building and Transforming Australian Industries'. The use of state of the art DNA sequencing results in huge amounts of data that is hard to interpret without the use of computers. This project builds Australia's capacity to deal with huge biological datasets by creating software and expertise in handling these datasets. The application of this softwa ....Bioinformatics network for the interrogation of adult stem cells. This project addresses the National Research Priority 'Frontier Technologies for Building and Transforming Australian Industries'. The use of state of the art DNA sequencing results in huge amounts of data that is hard to interpret without the use of computers. This project builds Australia's capacity to deal with huge biological datasets by creating software and expertise in handling these datasets. The application of this software and expertise to our stem cell population in Parkinson's disease patients will enable new insight into the difference between patients and controls.Read moreRead less
Special Research Initiatives - Grant ID: SR0354716
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainabilit ....Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainability of the earth - oceans, atmosphere, biosphere, CO2-free energy production, space and solar environment. The network would facilitate the development of young investigators and be linked into wider complex systems networks such as the CSIRO Centre for Complex Systems Science.Read moreRead less
The nature of self-recognition: novel approaches to vexing questions. Mirror self-recognition has often been interpreted as evidence for the presence of some form of self-concept/awareness. Children from age 2 onwards investigate their own bodies after seeing a novel mark on their heads in the mirror (surreptitiously placed in their hair by the experimenter). Younger children and most animals do not respond to their images in such a way (instead, for example, treating it as another individual). ....The nature of self-recognition: novel approaches to vexing questions. Mirror self-recognition has often been interpreted as evidence for the presence of some form of self-concept/awareness. Children from age 2 onwards investigate their own bodies after seeing a novel mark on their heads in the mirror (surreptitiously placed in their hair by the experimenter). Younger children and most animals do not respond to their images in such a way (instead, for example, treating it as another individual). The present experiments probe the nature of self-recognition using novel digital video technology rather than mirrors. This technology allows us to manipulate the contingency and appearance of the image. Five studies investigate the performance of 2 to 4-year-old children, autistic children, chimpanzees and dolphins to determine whether they recognize themselves and what underwrites their performance on the tasks. The innovative use of modern technology is expected to answer some of the most persistent questions in psychology.
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Electrochemically Driven Molybdoenzyme Catalysis. Enzymes that catalyse oxidation and reduction reactions need to exchange electrons with their substrate and this supply of electrons needs to be sustained. Artificially reconstituted systems can be developed where the enzyme is coupled with an electrode and the current (electrons) exchanged during the reaction are measured directly. In this project we will reveal whether some unusual and unexplained electrochemical phenomena seen before are relat ....Electrochemically Driven Molybdoenzyme Catalysis. Enzymes that catalyse oxidation and reduction reactions need to exchange electrons with their substrate and this supply of electrons needs to be sustained. Artificially reconstituted systems can be developed where the enzyme is coupled with an electrode and the current (electrons) exchanged during the reaction are measured directly. In this project we will reveal whether some unusual and unexplained electrochemical phenomena seen before are related to the properties of the enzymes themselves or the ways in which their experiments have been conducted.Read moreRead less