Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease. Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases th ....Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease. Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases that threaten vision. This project will investigate molecular activities of retinal endothelial cells that are relevant to retinal disease processes and explore future biological therapies directed against the human retinal endothelial cell that address efficacy and safety deficiencies of current treatments.Read moreRead less
The new voice of Multicultural Australian English. This project aims to generate an integrated and inclusive model of Australian-English, through phonetic analysis of the spoken language used by adolescents from a range of ethnic backgrounds. Australia is one of the most ethnically diverse countries in the world yet the complex relationship between speech production and cultural diversity is largely unknown in 21st century multicultural Australia. This project aims to establish how adolescents f ....The new voice of Multicultural Australian English. This project aims to generate an integrated and inclusive model of Australian-English, through phonetic analysis of the spoken language used by adolescents from a range of ethnic backgrounds. Australia is one of the most ethnically diverse countries in the world yet the complex relationship between speech production and cultural diversity is largely unknown in 21st century multicultural Australia. This project aims to establish how adolescents from different ethnicities use speech patterns to symbolically express their diverse sociocultural identities. The project expects to inform sociophonetic theories of variation, ethnicity, and identity, providing a framework for supporting sociocultural cohesion in Australia. Read moreRead less
Using language to predict cognitive outcomes in old age. This project aims to understand the relationship between linguistic complexity metrics and cognitive decline in old age. The project will test the hypothesis that high linguistic complexity scores reflect the ability to strategically optimise processing in the face of age-related reductions in processing capacity. By studying the relation between complexity scores and real-time information processing (measured via electroencephalography) a ....Using language to predict cognitive outcomes in old age. This project aims to understand the relationship between linguistic complexity metrics and cognitive decline in old age. The project will test the hypothesis that high linguistic complexity scores reflect the ability to strategically optimise processing in the face of age-related reductions in processing capacity. By studying the relation between complexity scores and real-time information processing (measured via electroencephalography) across the adult lifespan (20–80 years), this project will develop a simple and accurate marker of the individual balance between processing capacity and strategy. This project has the potential to increase quality of life for the elderly and reduce costs of age-related cognitive impairment.Read moreRead less