Work, care, retirement and health: ageing agendas. This project will undertake a gendered analysis of how Australians can retire well, taking account of their key resources (such as work, superannuation, the aged pension, and other assets) and key demands (such as to work longer and to care for others in the context of an ageing population and a more feminised workforce).
Changing approaches to gender and development in rural China. Harmonious and cooperative relations with China are crucial to Australia's economic and cultural development and to security in the region. By contributing to Australian understanding of Chinese society, this project will enhance such relations. Knowledge gained through this project will also enhance Australian development projects in China, and more generally, contribute to development projects focusing on gender and development in A ....Changing approaches to gender and development in rural China. Harmonious and cooperative relations with China are crucial to Australia's economic and cultural development and to security in the region. By contributing to Australian understanding of Chinese society, this project will enhance such relations. Knowledge gained through this project will also enhance Australian development projects in China, and more generally, contribute to development projects focusing on gender and development in Asia and elsewhere. In addition, the contributions of the project to research and postgraduate training in Chinese studies, gender studies and development studies will benefit Australia by raising the international profile of Australian institutions within these disciplines.Read moreRead less
Development Of Therapeutically Useful Human Artificial Chromosomes For Gene Delivery And Optimal Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$496,986.00
Summary
Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in ....Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in terms of infection, immune response, and germline modification. We have developed the first stage of a new technology for gene delivery that does not require the use of viruses. This technology is based on the generation of human artificial chromosomes, which are smaller versions of the naturally occurring chromosomes that carry all the genes inside our cells. Safety in these artificial chromosomes comes from the use of entirely human materials for their engineering. These artificial chromosomes also have other advantages over the viral approaches, including allowing large genes to be carried, and providing a permanent cure in a single treatment. We have already successfully constructed, published, and patented a number of first-generation human artificial chromosomes. The current project aims to complete the next proof-of-concept milestone towards the further development of this technology. Specifically, we propose to demonstrate the ability of the artificial chromosomes to carry genes and provide sustainable expression of these genes in cells and in animal models. Success in this study will allow the technology to proceed rapidly into commercialisation and clinical trial as a new improved tool for gene delivery and gene therapy.Read moreRead less
Sisters and Sojourners: Stories of Rural Women in Urban China. A large increase in unofficial rural to urban migration has been one of the most significant aspects of social change in China in the last two decades. This project aims to advance our understanding of this phenomenon through a study of rural Chinese women's experiences of migration to the city, and in particular, the effects of migration upon their sense of identity, worldview and relationships with others. The project will involv ....Sisters and Sojourners: Stories of Rural Women in Urban China. A large increase in unofficial rural to urban migration has been one of the most significant aspects of social change in China in the last two decades. This project aims to advance our understanding of this phenomenon through a study of rural Chinese women's experiences of migration to the city, and in particular, the effects of migration upon their sense of identity, worldview and relationships with others. The project will involve ethnographic fieldwork, centring on the collection and analysis of rural migrant women's life stories. It will result in the publication of a book and three scholarly articles.Read moreRead less
Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining ....Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining fertility and encouraging women into paid work. Identifying measures that most support men and women to balance work-family commitments, to spend adequate time with their children and social networks, and most facilitate female workforce participation, will promote national wellbeing. Read moreRead less
The sexual cultures of Thai men; implications for Australia's international HIV/AIDS strategy. This project contributes to safeguarding Australia's national interests by supporting the implementation of AusAID's international HIV/AIDS strategy laid out in the policy document 'Meeting the Challenge: Australia's International HIV/AIDS Strategy' (2004). This project directly addresses research priorities identified in the analytical report for the White Paper on Australia's AID program, 'HIV/AIDS i ....The sexual cultures of Thai men; implications for Australia's international HIV/AIDS strategy. This project contributes to safeguarding Australia's national interests by supporting the implementation of AusAID's international HIV/AIDS strategy laid out in the policy document 'Meeting the Challenge: Australia's International HIV/AIDS Strategy' (2004). This project directly addresses research priorities identified in the analytical report for the White Paper on Australia's AID program, 'HIV/AIDS in the Asia Pacific Region' (AusAID 2005): (1) the cultural, economic, and political dynamics driving the HIV epidemic in Asia; (2) the nexus between HIV/AIDS, economic activity, and development; and (3) the Asian experience of feminisation and gender impacts as factors in the epidemic HIV in the region.Read moreRead less
Reforming the Male: Masculinity, Medicalisation and Men's Health. Men's health is an issue of significant national importance and community concern. This project will contribute to knowledge of the social and cultural determinants of men's health and health practices in Australia. It is at the forefront of new approaches to men's health which emphasise the impact of norms and practices of masculinity on wellbeing. As well as providing specific insight into problems such as attention deficit di ....Reforming the Male: Masculinity, Medicalisation and Men's Health. Men's health is an issue of significant national importance and community concern. This project will contribute to knowledge of the social and cultural determinants of men's health and health practices in Australia. It is at the forefront of new approaches to men's health which emphasise the impact of norms and practices of masculinity on wellbeing. As well as providing specific insight into problems such as attention deficit disorder and depression in men, the project will also contribute to international debate about medicalisation, the rise of pharmacological treatments for problems of living and the existence of a crisis in masculinity.
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Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these ....New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these areas are important to the Biotechnology industry. Answering questions about higher order chromatin structure in gene transcription will provide cutting edge, innovative knowledge that will have international significance. Read moreRead less