Isolation And Function Of Human Oogenesis Genes Regulating Meiosis, Recruitment, Growth And Maturation Of The Oocyte.
Funder
National Health and Medical Research Council
Funding Amount
$211,527.00
Summary
Reproductive medicine has progressed very rapidly with the development of in vitro fertilization (IVF) and has delivered the opportunity for a broad group of infertile couples to form their own families. As a consequence, treatment of infertility by major surgery and artificial insemination with donor sperm have declined and there is an increasing interest in the use of IVF to diagnose severe genetic disease in embryos of families at risk. However, little is known about the underlying processes ....Reproductive medicine has progressed very rapidly with the development of in vitro fertilization (IVF) and has delivered the opportunity for a broad group of infertile couples to form their own families. As a consequence, treatment of infertility by major surgery and artificial insemination with donor sperm have declined and there is an increasing interest in the use of IVF to diagnose severe genetic disease in embryos of families at risk. However, little is known about the underlying processes that form the follicles containing the developing germ cells and the matured oocytes needed for IVF. The cohort of oocytes that can be harvested from any patient depends on unknown recruitment processes initiating development of a subset of the quiescent germ cells and happens in an unregulated and spontaneous manner. The present project will identify the known and unknown genes involved in recruitment of oocytes from the basal primordial population. These genes will become candidates for aiding infertile women, improving their response to fertility drugs, the development of novel contraceptive methods and potentially increasing the reproductive life span of women. Knowledge of the genes expressed in oocytes matured in vivo and in vitro will have an important bearing on the long-term opportunity to use fertility drugs in vitro instead of administration to patients for IVF. This would dramatically reduce the cost of IVF and the side-effects of hyperstimulation of ovaries of patients and the associated sequelae. The research project is a discovery program leading to the identification of the genes that govern oogenesis in the human. It is only recently that techniques have been developed to sufficient sensitivity to detect the small quantities of RNA proceeded by active genes in the individual germ cells and oocytes.Read moreRead less
Molecular Cascades Determining Asexual-sexual Development In Echinococcus Granulosus
Funder
National Health and Medical Research Council
Funding Amount
$312,576.00
Summary
Hydatid disease is a zoonosis caused by the dog tapeworm Echinococcus with millions of people-animals infected. After decades of study, effective treatment remains a major challenge. We will use a combination of recently developed techniques to isolate specific genes associated with Echinococcus differentiation. Understanding how these genes are controlled will increase our sparse knowledge of the developmental biology of this important parasite and provide new clues for more effective therapies
Restructuring the male breadwinner model: New challenges for a rapidly changing Australia. This project investigates changes to the Australian male breadwinner gender order in the key spheres of labour markets, households and public policies. Gender arrangements in these spheres play a key role in economic development reflecting the intertwining of economic and social processes in a country's well-being. Increased understanding of the implications of current changes affecting the gender order an ....Restructuring the male breadwinner model: New challenges for a rapidly changing Australia. This project investigates changes to the Australian male breadwinner gender order in the key spheres of labour markets, households and public policies. Gender arrangements in these spheres play a key role in economic development reflecting the intertwining of economic and social processes in a country's well-being. Increased understanding of the implications of current changes affecting the gender order and social reproduction will enhance economic well-being for both individuals and society in Australia. The impact of these changes are vital policy issues. This international collaboration will develop a conceptual framework for identifying policy reform to strengthen Australia's social and economic sustainability.Read moreRead less
Work, care, retirement and health: ageing agendas. This project will undertake a gendered analysis of how Australians can retire well, taking account of their key resources (such as work, superannuation, the aged pension, and other assets) and key demands (such as to work longer and to care for others in the context of an ageing population and a more feminised workforce).
The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being dev ....The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being developed in several States following pay equity inquiries. Expected outcomes include enhanced comprehension of the reproduction of pay inequality and evidence to assist the advancement of pay equity through identified mechanisms and strategies.Read moreRead less
Industrial relations, gender equity and work/family balance: assessing the impact of changing law and practice in Queensland. The project has potential to contribute to improvements in the economic and social well-being of Australian families and communities by identifying effective strategies to enhance gender equity in employment and work/family balance. It seeks to extend understanding of how these outcomes vary across regions and sectors of the Queensland economy in the context of a changing ....Industrial relations, gender equity and work/family balance: assessing the impact of changing law and practice in Queensland. The project has potential to contribute to improvements in the economic and social well-being of Australian families and communities by identifying effective strategies to enhance gender equity in employment and work/family balance. It seeks to extend understanding of how these outcomes vary across regions and sectors of the Queensland economy in the context of a changing industrial relations framework, and to provide an evidence-base to inform the best ways to secure high quality employment and labour force attachment over the life course.Read moreRead less
Parental leave: access, utilisation and efficacy in Australia. This project addresses significant gaps in knowledge about the use of parental leave and the work/family preferences of men and women in Australia. It aims to advance current theoretical debates on how preferences are shaped in workplaces and households, and provide detailed data to inform policy processes. These are highly significant goals as Australian governments prioritise work/family issues in the context of changing household ....Parental leave: access, utilisation and efficacy in Australia. This project addresses significant gaps in knowledge about the use of parental leave and the work/family preferences of men and women in Australia. It aims to advance current theoretical debates on how preferences are shaped in workplaces and households, and provide detailed data to inform policy processes. These are highly significant goals as Australian governments prioritise work/family issues in the context of changing household structures, falling fertility rates, ageing populations and working time pressures. Expected outcomes include benchmarks for policy evaluation, improved understanding of preferences and enhanced policy frameworks to facilitate a gender egalitarian work/family balance.Read moreRead less