The long-term side effects of renal denervation are unknown. This project is designed to (1) investigate the potential atherosclerosis-promoting effect of renal denervation, and (2) to study the effectiveness of anti-inflammatory drugs to minimize this potential side effect. Ultimately, this project may improve the beneficial effects and minimize the potential side effects of renal denervation by routinely treating renal denervated patients with anti-inflammatory drugs.
A Study Of Statins For Reducing Events In The Elderly
Funder
National Health and Medical Research Council
Funding Amount
$5,372,965.00
Summary
Statins prevent heart attacks and strokes in people who have already experienced one or are at high risk. Statins are thought to do this by lowering cholesterol levels and improving the function of blood vessels. It is not known whether people 75 years or over should receive this therapy, as past studies have not included older people because they are more likely to suffer from drug side effects. This study will investigate the benefits versus risks of statins in healthy elderly people.
Pre-clinical Assessment Of The Therapeutic Potential Of Targeting The Hippo Pathway In Muscle Wasting & Muscle-derived Cancer
Funder
National Health and Medical Research Council
Funding Amount
$621,979.00
Summary
Recent findings have identified the Hippo signalling pathway as an important regulator of processes in muscle fibres and muscle progenitor cells. This project will look at the significance of the Hippo pathway in the development of muscle wasting caused by statin administration, and in the genesis of muscle derived tumors (rhabdomyosarcoma). The studies will determine if interventions that regulate the Hippo pathway could provide new therapies for these important muscle-related diseases.
Intervention To Reduce The Risk Of Diabetic Retinopathy And Early Adverse Retinal Changes In Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$1,294,846.00
Summary
The long term effects of young onset T1D may be devastating: diabetes is the leading cause of visual loss in young adults in Australia and other countries. We have the unique opportunity to investigate whether ACEI and statins will modify retinopathy through our collaboration with an already funded international multicentre trial. This study will treat adolescents for 4 years and will follow them for the next 5-10 years. We will use novel measures of retinal blood vessels size and fractals.
Does Statin Use Have A Disease Modifying Effect In Symptomatic Knee Osteoarthritis? A Multicentre Randomised, Double-blind, Placebo-controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,002,987.00
Summary
Osteoarthritis (OA) is a major cause of knee pain and disability. Treatments are limited to reducing pain and improving function: no therapy slows disease progression, with symptomatic end-stage OA treated by knee replacement. Statins, a drug class used to lower cholesterol levels, may affect the structural progression in knee OA. We propose a randomised controlled trial to see if statin use slows the progression of knee OA, which would delay or prevent the need for joint replacement.
Depression is the most prevalent health problem in young people, with a prevalence as high as 24 percent. There is evidence demonstrating a link between depression and chronic inflammation and oxidative stress, suggesting that drugs which modulate those factors may have antidepressant properties. This study is designed to establish whether the use of (i) rosuvastatin or (ii) aspirin, two drugs that modulate both the inflammatory and oxidative systems, reduce symptoms of depression in young peopl ....Depression is the most prevalent health problem in young people, with a prevalence as high as 24 percent. There is evidence demonstrating a link between depression and chronic inflammation and oxidative stress, suggesting that drugs which modulate those factors may have antidepressant properties. This study is designed to establish whether the use of (i) rosuvastatin or (ii) aspirin, two drugs that modulate both the inflammatory and oxidative systems, reduce symptoms of depression in young people with major depression.Read moreRead less