Validating And Optimising The Analysis Of Magnetic Resonance Physiology Data
Funder
National Health and Medical Research Council
Funding Amount
$91,725.00
Summary
Combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is used to detect the anatomical areas in the brain that show electrical activity. Several centres worldwide use this technique to localise the seizure focus in patients with epilepsy. However, there is a lack of validation of the currently applied techniques. Current analysis methods have been developed and validated for other fMRI paradigms, such as motor tasks. It is not known whether the same principles ar ....Combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is used to detect the anatomical areas in the brain that show electrical activity. Several centres worldwide use this technique to localise the seizure focus in patients with epilepsy. However, there is a lack of validation of the currently applied techniques. Current analysis methods have been developed and validated for other fMRI paradigms, such as motor tasks. It is not known whether the same principles are applicable and optimal for fMRI-EEG data. The proposed project aims at validating and optimising the analysis strategies for fMRI-EEG data.Read moreRead less
Are The Energy Expenditures Of Household And Garden Chores Of Sufficient Intensity To Confer Health Benefits?
Funder
National Health and Medical Research Council
Funding Amount
$322,110.00
Summary
Participation in regular moderate to vigorous intensity physical activity reduces risk for cardiovascular disease, non-insulin dependent diabetes, osteoporosis and some cancers. Recent epidemiological recommendations are that 30 minutes of moderate intensity physical activity (e.g. brisk walking at 4.8-6.4 km-hr) on most days is sufficient to confer these significant health benefits. However, many Australians spend substantial amounts of time engaged in household chores and gardening - yardwork ....Participation in regular moderate to vigorous intensity physical activity reduces risk for cardiovascular disease, non-insulin dependent diabetes, osteoporosis and some cancers. Recent epidemiological recommendations are that 30 minutes of moderate intensity physical activity (e.g. brisk walking at 4.8-6.4 km-hr) on most days is sufficient to confer these significant health benefits. However, many Australians spend substantial amounts of time engaged in household chores and gardening - yardwork activities but it is unknown whether the intensities of these activities are sufficient to confer the aforementioned health benefits. The aims of this study are therefore to: 1. Measure directly the energy cost of self-paced common household chores and gardening - yard activities. 2. Provide data that are required to estimate accurately the prevalence of 'adequate' levels of physical activity among adults. 3. Identify indirect methods (such as heart rate, motion and breathing frequency) which, in combination, are suitable for use in large scale surveys of activity levels. The outcomes of this study will be: 1. A greatly improved understanding of whether energy expenditure associated with self-paced household chores and gardening - yard activities is adequate to confer health benefits. 2. Our results will be used in key public health interventions which are aimed at modifying the physical activity levels of Australians. 3. If the public health message encourages some of the ~30% of sedentary Australians to undertake regular moderate intensity physical activity then this will: reduce the cost of the health care system, substantially reduce the premature loss of life and decrease morbidity and disability. 4. Our results will help public health epidemiologists to monitor the percentage of Australians who are adequately physically active.Read moreRead less
Developing And Applying Biologically Plausible Statistical Models For Normal And Non-normal Family Data
Funder
National Health and Medical Research Council
Funding Amount
$339,700.00
Summary
Although molecular and computing advances have enabled more detailed investigations of inherited diseases and the ability to fit realistic statistical models to these data, limitations still exist when analysing family data. Often only basic statistical analyses are performed, due to the lack of understanding of complexities within the data and-or inability of researchers to fit appropriate statistical models. These factors have hampered the search for genes and environmental factors influencing ....Although molecular and computing advances have enabled more detailed investigations of inherited diseases and the ability to fit realistic statistical models to these data, limitations still exist when analysing family data. Often only basic statistical analyses are performed, due to the lack of understanding of complexities within the data and-or inability of researchers to fit appropriate statistical models. These factors have hampered the search for genes and environmental factors influencing common diseases. This project aims to develop novel, biologically realistic statistical models for investigation of common, complex diseases, such as heart disease and cancer, in families. These models will incorporate both measured and unmeasured genetic and environmental factors, and will be applicable to both normally distributed and non-normally distributed traits. Model fitting will use computer-intensive simulation techniques. Application of the models to data from two large pre-existing studies of international renown, the Victorian Family Heart Study and the Australian Prostate Cancer Family Study, will enable a better understanding of the genetic and environmental factors influencing heart disease and cancer. The models will also be applicable to many other studies of diseases which use data from families, and allow more accurate and useful information to be obtained from data. Software will also be made freely available to other researchers. This will ultimately translate into better outcomes from familial genetic research, and eventually, better prevention, detection, and treatment of the diseases.Read moreRead less
Strategies For Handling Missing Data In The Development, Validation And Implementation Of Clinical Risk Prediction Tools
Funder
National Health and Medical Research Council
Funding Amount
$451,692.00
Summary
Tools that predict the future outcome of disease are common. Missing data is a problem in studies that develop and validate such tools and affects their validity because simple approaches to dealing with missing data are biased. We will develop statistical methodology in this area and compare the performance of this and other methodologies. Alongside this methodological work we will re-assess existing prediction tools and develop new tools in the areas of cardiac surgery and kidney disease.
Improving Medication Safety In Seniors: A Cross-Jurisdictional Linkage Project
Funder
National Health and Medical Research Council
Funding Amount
$636,717.00
Summary
The project will identify priorities for tackling the current epidemic of hospitalisation of Australians aged 65+ years due to side effects of their medications. Two different groups of medications will be investigated. The first will be the prescribed drugs most often recorded as causes of hospital stay, including those taken to stop blood clotting, for high blood pressure and other cardiovascular problems, for rheumatism or strong pain relief, anti-cancer drugs and steroids. The study will exa ....The project will identify priorities for tackling the current epidemic of hospitalisation of Australians aged 65+ years due to side effects of their medications. Two different groups of medications will be investigated. The first will be the prescribed drugs most often recorded as causes of hospital stay, including those taken to stop blood clotting, for high blood pressure and other cardiovascular problems, for rheumatism or strong pain relief, anti-cancer drugs and steroids. The study will examine which of these drugs taken under what circumstances has the highest risk, so prevention can be better targeted. The study will investigate if adequate laboratory monitoring of the anti- clotting drugs is taking place and whether the guidelines should be updated. The second group will be 68 medications that should be avoided in seniors according to an international expert panel. The research will see how often these 'inappropriate medications' are still prescribed in the Australian setting, and the size of their contributions to unplanned hospital stays. The researchers suspect that this problem is much larger than immediately apparent from routine statistics, because many of the side effects of inappropriate medications are non-specific, such as confusion, drowsiness or difficulty standing up, thus putting seniors at risk of falls and neglect of other aspects of their health. The study will use a unique and new Australian research facility, which has brought together health data on the entire population of WA from both the State and Commonwealth levels, including information on pharmaceuticals, Medicare use, hospital stays and deaths. The facility works in such a way as to preserve patient and GP privacy. A strong feature of this research will be the degree of involvement of a representative and voluntary group of older Australian patients who attend GP clinics, and the GPs themselves, in advising the researchers on what's important to consumers and GPs.Read moreRead less
Discovery And Validation Of Alzheimer�s Disease Biomarkers In Human Plasma
Funder
National Health and Medical Research Council
Funding Amount
$365,126.00
Summary
With life expectancy increasing Alzheimer�s disease (AD) poses a rising medical and socioeconomic challenge, emphasising the need for the development of prevention and treatment strategies. Such strategies will be most effective if administered early in the disease process, making early diagnosis critical to their success. The identification of biomarkers in this project, which are altered during the development of AD, will lead to the development of such a means to diagnosis AD at an early stag ....With life expectancy increasing Alzheimer�s disease (AD) poses a rising medical and socioeconomic challenge, emphasising the need for the development of prevention and treatment strategies. Such strategies will be most effective if administered early in the disease process, making early diagnosis critical to their success. The identification of biomarkers in this project, which are altered during the development of AD, will lead to the development of such a means to diagnosis AD at an early stage, when interventions will have the most impact.Read moreRead less