Overcoming the Barriers in the Development of Solid State Materials. A major impact of this proposal shall be in terms of researcher training. By synergistically combining materials chemistry, fundamental physical chemistry, inorganic chemistry, and electrochemistry, this basic program will provide high level training to a new generation of Australian and Irish scientists thus helping to safeguard the economic competitiveness of the countries. Beyond the impact of the fundamental insight into t ....Overcoming the Barriers in the Development of Solid State Materials. A major impact of this proposal shall be in terms of researcher training. By synergistically combining materials chemistry, fundamental physical chemistry, inorganic chemistry, and electrochemistry, this basic program will provide high level training to a new generation of Australian and Irish scientists thus helping to safeguard the economic competitiveness of the countries. Beyond the impact of the fundamental insight into the rational design, structure and behaviour of a new class of solid materials, success in this program will have widespread applications for a variety of strategically important industries and should place Australia and Ireland at the forefront of this technologyRead moreRead less
Peptide Nucleic Acid Based Sensors and Devices - An Investigation into PNA Versatility for Emerging Gene Technologies. Peptide nucleic acids (PNAs) are analogues of DNA that may have important implications as therapeutic agents for the cure of diseases based on genetic defects. The attributes of PNAs that make them potentially viable as a drug are also well suited to their development as sensors and molecular devices. In this proposal, we wish to develop a series of PNAs containing photoactive ....Peptide Nucleic Acid Based Sensors and Devices - An Investigation into PNA Versatility for Emerging Gene Technologies. Peptide nucleic acids (PNAs) are analogues of DNA that may have important implications as therapeutic agents for the cure of diseases based on genetic defects. The attributes of PNAs that make them potentially viable as a drug are also well suited to their development as sensors and molecular devices. In this proposal, we wish to develop a series of PNAs containing photoactive elements (a) as alternatives to commercially-available fluorophores, (b) for the early detection of neurodegenerative diseases and (c) to contribute to one of Science's most debated issues i.e. "does DNA mediate electron transport?"Read moreRead less
Three Dimensional Anti-biofouling Conducting Polymer Hydrogel Electrodes for Biosensor and Biofuel cell Applications. Exploitation of advances in nanotechnology, electrochemical technology, biosensor, biofuel cell and material science are important to Australia's prosperity from a societal industrial perspective. Currently, research in this field is being actively conducted around the world due to their huge potential for commercial applications. Therefore, through the development of new princi ....Three Dimensional Anti-biofouling Conducting Polymer Hydrogel Electrodes for Biosensor and Biofuel cell Applications. Exploitation of advances in nanotechnology, electrochemical technology, biosensor, biofuel cell and material science are important to Australia's prosperity from a societal industrial perspective. Currently, research in this field is being actively conducted around the world due to their huge potential for commercial applications. Therefore, through the development of new principles and concepts, and the synthesis of newly designed materials, this project will bring significant benefits in improving the efficiency of these devices and to promote Australian leadership in the field of medical devices and alternative energy generation.Read moreRead less
Paper fluidics - A novel approach to low cost printable microsensors. Printing is perhaps the cheapest means of mass production available, yet it is used almost exclusively to mass produce only one thing, i.e. the printed word! This project will enable the development of disposable printed sensors for assessing the quality of water or the health of an individual. Sensors are generally relatively expensive, but the ability to print them on paper by the thousand will bring down the cost to a few ....Paper fluidics - A novel approach to low cost printable microsensors. Printing is perhaps the cheapest means of mass production available, yet it is used almost exclusively to mass produce only one thing, i.e. the printed word! This project will enable the development of disposable printed sensors for assessing the quality of water or the health of an individual. Sensors are generally relatively expensive, but the ability to print them on paper by the thousand will bring down the cost to a few cents. Such cheap, portable, easy-to-use sensors if widely available could profoundly affect the lives of people living in remote areas and developing countries.Read moreRead less
New Imaging Agents for Neuronal Nicotinic Receptors. Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerat ....New Imaging Agents for Neuronal Nicotinic Receptors. Recent advances in medical imaging technology such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have radically improved the diagnosis and treatment of a wide range of diseases. The aim of this project is to discover novel radio-ligands that selectively bind to neuronal nicotinic acetylcholine receptors. These ligands will have great potential for the imaging, diagnosis and study of neurodegenerative diseases such as Alzheimer's disease. Read moreRead less
Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercial ....Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercially viable product - the neutral helium beam microscope. The possibilities of using the microscope system as a nanofabrication device would also give researchers in Australia the ability to fabricate structures that could not be manufactured anywhere else in the world.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453651
Funder
Australian Research Council
Funding Amount
$907,511.00
Summary
Small Molecule NMR Facility for Accelerated Drug Discovery. This project will accelerate the drug discovery process by establishing a world-class small-molecule Nuclear Magnetic Resonance (NMR) facility. The requested instrumentation will enable high throughput structural analysis of synthetic lead compounds, expedite natural product isolation and identification and enhance NMR-based drug screening. This facility will support both existing and new programs in Victorian universities, particularly ....Small Molecule NMR Facility for Accelerated Drug Discovery. This project will accelerate the drug discovery process by establishing a world-class small-molecule Nuclear Magnetic Resonance (NMR) facility. The requested instrumentation will enable high throughput structural analysis of synthetic lead compounds, expedite natural product isolation and identification and enhance NMR-based drug screening. This facility will support both existing and new programs in Victorian universities, particularly Medicinal and Biological Chemistry, and achieve internationally competitive research capabilities. Outcomes will include the development of new pharmaceuticals, increased local and international collaboration and the training of new scientists in state-of-the-art spectroscopic techniques for identification of natural products and synthetic molecules of pharmacological importance.
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Joint Theoretical and Experimental Electron Momentum Spectroscopic Studies for DNA Bases. The study of DNA structure is an area of intense research activity and continues to reveal new levels of complexity and diversity. Recent experiments (Science, 2002) provided direct evidences of the adenine non-planarity, indicating non-rigidity of DNA bases. Electron momentum spectroscopy (EMS) has been identified to be an appropriate technique in the study of chemical binding mechanism and orbitals at mol ....Joint Theoretical and Experimental Electron Momentum Spectroscopic Studies for DNA Bases. The study of DNA structure is an area of intense research activity and continues to reveal new levels of complexity and diversity. Recent experiments (Science, 2002) provided direct evidences of the adenine non-planarity, indicating non-rigidity of DNA bases. Electron momentum spectroscopy (EMS) has been identified to be an appropriate technique in the study of chemical binding mechanism and orbitals at molecular level. The aims of the project is to study orbitals and interactions of DNA and RNA bases such as adenine, thymine (uracil), guanine and cytosine using momentum space quantum mechanics and EMS experimental techniques. The outcome of the project will improve our understanding of the DNA double helical strand structure.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346895
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance ex ....A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance existing excellence in a range of areas. Finally, the laboratory will provide opportunities to: collaborate and consult with industry; train postgraduate students in instrumentation used at the cutting edge of chemical and biochemical sciences.Read moreRead less
Tailoring the optical properties of matter with Sol-Gel: innovative optical materials for 3D photonic crystals with complete photonic band-gap. The success of this project will allow for improvement of existing technologies in diverse fields, from optics to green energy production. Realization of 3D complete Photonic Band-Gap (PBG) structures is the first step toward full optic-based data processing systems, which will be one of the most revolutionary achievements in technology after introductio ....Tailoring the optical properties of matter with Sol-Gel: innovative optical materials for 3D photonic crystals with complete photonic band-gap. The success of this project will allow for improvement of existing technologies in diverse fields, from optics to green energy production. Realization of 3D complete Photonic Band-Gap (PBG) structures is the first step toward full optic-based data processing systems, which will be one of the most revolutionary achievements in technology after introduction of electronic-based processors. Improvement of energy conversion efficiency of existing solar cells and polymer-based solar cells will be achievable thanks to implementation of PhCs as high-reflective layers. The establishment of scaleable protocols for production of high quality materials for photonics will put Australia among the leading countries in the future photonic-devices market.Read moreRead less