Comparative Expression Studies To Identify Cellular Factors Promoting Hendra Virus Replication For A Comprehensive Understanding Of Hendra Virus Pathogenesis
Funder
National Health and Medical Research Council
Funding Amount
$374,619.00
Summary
Hendra virus (HeV) is an emerging pathogen indigenous to fruit bats. HeV is associated with limited outbreaks with high mortality in domesticated animals and humans. To advance the understanding of HeV-related pathogenesis, we will perform comparative studies in bat and human cell lines to recognise differences in virus-host cell interactions leading to a comprehensive understanding of the HeV life cycle and pathogenesis.
Defining The Role Of MiR-146a In Human Hendra Virus Infections
Funder
National Health and Medical Research Council
Funding Amount
$348,998.00
Summary
This project aims to improve the medical management of people infected with Hendra virus by defining potential therapeutic windows for treatment with antiviral strategies. The project involves the study of microRNAs, a class of small ribonucleic acid molecules that regulate biological processes in eukaryotes. We will determine the role of microRNAs in the Hendra virus infection process in humans, and their application as diagnostic markers of Hendra virus infection.