Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100118
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Nuclear magnetic resonance spectroscopy facilities for the Sydney region. The determination of molecular structure is crucial in the chemical and biomolecular sciences, leading to the development of new drugs and other types of molecules and providing an understanding of how molecules interact with each other. The requested equipment will provide the ability for researchers in the Sydney region to advance our knowledge at this fundamental level by expanding the number and types of experiments th ....Nuclear magnetic resonance spectroscopy facilities for the Sydney region. The determination of molecular structure is crucial in the chemical and biomolecular sciences, leading to the development of new drugs and other types of molecules and providing an understanding of how molecules interact with each other. The requested equipment will provide the ability for researchers in the Sydney region to advance our knowledge at this fundamental level by expanding the number and types of experiments that can be performed.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100135
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Federated single crystal X-ray structural analysis facility. X-ray crystallography is the most widely applied method for the determination of three-dimensional molecular structures. These structures range in size from small systems such as materials and pharmaceuticals through to large biological structures such as proteins. This application will provide a multidisciplinary facility covering the structural characterisation needs of chemistry, pharmacy, biology, and medicine. This will position l ....Federated single crystal X-ray structural analysis facility. X-ray crystallography is the most widely applied method for the determination of three-dimensional molecular structures. These structures range in size from small systems such as materials and pharmaceuticals through to large biological structures such as proteins. This application will provide a multidisciplinary facility covering the structural characterisation needs of chemistry, pharmacy, biology, and medicine. This will position local universities for key scientific breakthroughs that benefit the Australian community by providing improved healthcare technologies, and processes. Furthermore, access to this world-class facility will provide state-of-the-art training for undergraduate, postgraduate and postdoctoral researchers.Read moreRead less
Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal w ....Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal will receive international recognition and will encourage more research in this field, attracting international funding, and create new research opportunities. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668382
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
e-Research Infrastructure for the Molecular and Materials Structure Sciences. Understanding molecular and materials structure in atomic detail is vital to a knowledge-based economy and a healthy society. The development of smart materials, nanotechnological devices, hydrogen storage materials, molecular switches, magnets and sensors, for example, depends on knowledge of three-dimensional atomic structure. Cures for illnesses such as SARS, AIDS and Alzheimer's disease and understanding the aging ....e-Research Infrastructure for the Molecular and Materials Structure Sciences. Understanding molecular and materials structure in atomic detail is vital to a knowledge-based economy and a healthy society. The development of smart materials, nanotechnological devices, hydrogen storage materials, molecular switches, magnets and sensors, for example, depends on knowledge of three-dimensional atomic structure. Cures for illnesses such as SARS, AIDS and Alzheimer's disease and understanding the aging process depends on knowledge of biomolecular structure. The deployment and development of automation-enhanced remote access to structural instruments through the web will greatly enhance Australian structure-based research, and make this science accessible to the public. Read moreRead less
3D Structure determination of biomacromolecular assemblies from sparse data. This project has direct impact on pharmaceutical research: Biomacromolecular interactions are key points for pharmaceutical intervention and detailed structural knowledge of dynamic protein interactions can significantly accelerate drug development. Australia has invested in expensive instrumentation that can be used with new laboratory methods to obtain information on delicately balanced biomacromolecular interactions, ....3D Structure determination of biomacromolecular assemblies from sparse data. This project has direct impact on pharmaceutical research: Biomacromolecular interactions are key points for pharmaceutical intervention and detailed structural knowledge of dynamic protein interactions can significantly accelerate drug development. Australia has invested in expensive instrumentation that can be used with new laboratory methods to obtain information on delicately balanced biomacromolecular interactions, and how they malfunction in disease. This project will provide a computational framework to increase the impact of this investment by integrating measurements from a range of novel technologies and developing understanding of changes in structure of large protein complexes in different functional states.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775676
Funder
Australian Research Council
Funding Amount
$290,000.00
Summary
An X-ray Diffraction Facility for Molecular Structure Determination. Characterisation of new chemical compounds demands proof of molecular structure. Whether for the identification of a new drug candidate, a material with novel properties or in the exploration of previously unknown types of compounds, X-ray crystallography is the definitive technique for this purpose. This proposal is for an X-ray diffractometer that will significantly enhance the capabilities of all synthetic and natural produc ....An X-ray Diffraction Facility for Molecular Structure Determination. Characterisation of new chemical compounds demands proof of molecular structure. Whether for the identification of a new drug candidate, a material with novel properties or in the exploration of previously unknown types of compounds, X-ray crystallography is the definitive technique for this purpose. This proposal is for an X-ray diffractometer that will significantly enhance the capabilities of all synthetic and natural products chemistry research programs undertaken at the Universities of Queensland and Newcastle, all currently in receipt of ARC funding. This research is aligned with the ARC National Research Priorities, of Promoting and Maintaining Good Health and Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
Thin Films of Oxide Ceramics. Aluminium oxide films are used extensively in the Australian industries of Protective & Decorative Coatings (examples include door-knobs and cutting-tools). The industry will be offered a remarkably simple process for preparation of high quality films. In the microelectronic industry, the uses of aluminium oxide films as a dielectric alternative to silicon dioxide has just started to emerge world - wide and this new process would make a dramatic impact with commerci ....Thin Films of Oxide Ceramics. Aluminium oxide films are used extensively in the Australian industries of Protective & Decorative Coatings (examples include door-knobs and cutting-tools). The industry will be offered a remarkably simple process for preparation of high quality films. In the microelectronic industry, the uses of aluminium oxide films as a dielectric alternative to silicon dioxide has just started to emerge world - wide and this new process would make a dramatic impact with commercial benefits for Australia. Read moreRead less
Special Research Initiatives - Grant ID: SR0354775
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Synchrotron Sciences Network. A synchrotron light source is a critical piece of infrastructure for a modern technological nation. In 2001, the Victorian government announced that it would contribute $157M towards the establishment of a national synchrotron facility, becoming operational in 2007. The research performed at such a facility is exceedingly diverse, and often the underpinning technology is the only point of contact for users. A vibrant and productive facility requires a tra ....Australian Synchrotron Sciences Network. A synchrotron light source is a critical piece of infrastructure for a modern technological nation. In 2001, the Victorian government announced that it would contribute $157M towards the establishment of a national synchrotron facility, becoming operational in 2007. The research performed at such a facility is exceedingly diverse, and often the underpinning technology is the only point of contact for users. A vibrant and productive facility requires a transparent interface between the scientist and the technology. This Network will set up the communication channels within the user base, and between the users and the facility development program.Read moreRead less
Structural and Electronic Properties of Layered Bismuth Oxides. A systematic study of the role of cation substitutions and temperature on the structural and electronic properties of a number of layered bismuth oxides will undertaken with the aim of developing improved ferroelectric materials for use in electronic devices.
Complex Phenomena and Phase Transitions in Ferroric Perovskites. The ultimate aim of this project is to identify high performance, multiferroic magnetoelectrics suitable for use in the next generation electronic devices. These oxides exhibit a strong interaction between the polarisation and magnetic response. Understanding the factors that control the response of such materials to applied magnetic and electric fields is critical to the discovery, optimization and, ultimately, industrial exploi ....Complex Phenomena and Phase Transitions in Ferroric Perovskites. The ultimate aim of this project is to identify high performance, multiferroic magnetoelectrics suitable for use in the next generation electronic devices. These oxides exhibit a strong interaction between the polarisation and magnetic response. Understanding the factors that control the response of such materials to applied magnetic and electric fields is critical to the discovery, optimization and, ultimately, industrial exploitation of such materials. Through comprehensive experimental and theoretical studies of a number of such materials this project will enhance the ability of industry to develop new and improved materials. Development of advanced materials is a designated National Research Priority area. Read moreRead less