Structural and functional investigations of the human transcription machinery by ion mobility-mass spectrometry. This project will apply emerging mass spectrometric technologies to gain previously inaccessible insight into human transcription factor proteins. This will reveal new avenues for intervention in human disease states related to aberrant gene expression, while developing innovative methods for the study of complex protein assemblies.
Three-dimensional structures, substrate specificities and catalytic mechanisms of polysaccharide synthases. Plant wall polysaccharides are extensively used for food and fibre, and are important dietary components in human nutrition. A precise knowledge of mechanisms used by plants to synthesize these polysaccharides is unavailable, but would reveal potential routes to manipulate their biosynthesis in important crop species. For example, the levels or structures of polysaccharides might be modif ....Three-dimensional structures, substrate specificities and catalytic mechanisms of polysaccharide synthases. Plant wall polysaccharides are extensively used for food and fibre, and are important dietary components in human nutrition. A precise knowledge of mechanisms used by plants to synthesize these polysaccharides is unavailable, but would reveal potential routes to manipulate their biosynthesis in important crop species. For example, the levels or structures of polysaccharides might be modified to improve their efficacy as anti-cancer agents in human diets, to enhance digestibility of animal stock feeds, or to synthesise pharmologically valuable compounds. Thus, economic, social and environmental benefits will flow to both producers and consumers. Read moreRead less
Fibre reinforced polymer retrofitting of reinforced concrete flexural members. A cost-effective and durable technique for retrofitting reinforced concrete beams and slabs is to adhesively bond new advanced fibre reinforced polymer (FRP) composites to their surfaces. The potential plating market in Australia for bridges is $350 million, however, the technique can also be applied to strengthening other structures such as buildings. Tests have shown that FRP plates or sheets can debond prematurely, ....Fibre reinforced polymer retrofitting of reinforced concrete flexural members. A cost-effective and durable technique for retrofitting reinforced concrete beams and slabs is to adhesively bond new advanced fibre reinforced polymer (FRP) composites to their surfaces. The potential plating market in Australia for bridges is $350 million, however, the technique can also be applied to strengthening other structures such as buildings. Tests have shown that FRP plates or sheets can debond prematurely, which at present severely limits the application. The aim of this research project is to quantify the debonding mechanisms, strengths and ductilities of adhesively bonded FRP plated beams to provide design rules that can be used in practice.Read moreRead less
Nanoscale characterisation of the dynamics of artificial lipid membranes - model systems for drug binding studies. This project will see the development of artificial membranes replicating the physiological behaviour of cell membranes providing a novel platform for in vitro drug evaluation clearing the way for the development of effective new therapies with fewer side effects.
Earthquake protection of masonry buildings using fibre reinforced polymer strengthening. The importance of this research is highlighted, both nationally and internationally, by the work of the insurance industry which reported that the economic risk posed by a moderate earthquake in any of the capital cities in Australia is of the order of billions of dollars (Blong, 1993). For example, a 'design magnitude' earthquake in Sydney is predicted to cause, just in domestic construction, over $10 bill ....Earthquake protection of masonry buildings using fibre reinforced polymer strengthening. The importance of this research is highlighted, both nationally and internationally, by the work of the insurance industry which reported that the economic risk posed by a moderate earthquake in any of the capital cities in Australia is of the order of billions of dollars (Blong, 1993). For example, a 'design magnitude' earthquake in Sydney is predicted to cause, just in domestic construction, over $10 billion damage and more than 5000 deaths. Most of this damage would be associated with unreinforced masonry construction such as low-rise apartment buildings. The damage bill for the entire built environment (with business interruption costs) could easily be an order of magnitude greater.Read moreRead less
Ductile FRP retrofit of concrete frames subject to static and earthquake loading. Australia needs to spend at least $500 million annually on the repair and upgrading of concrete structures alone just to maintain our existing civil infrastructure. Furthermore, it has been estimated that more than 500 deaths and $10 billion damage will be caused by a moderate earthquake in Sydney or Melbourne. Most of this damage will be due to the collapse of buildings. This research will develop a new form of ....Ductile FRP retrofit of concrete frames subject to static and earthquake loading. Australia needs to spend at least $500 million annually on the repair and upgrading of concrete structures alone just to maintain our existing civil infrastructure. Furthermore, it has been estimated that more than 500 deaths and $10 billion damage will be caused by a moderate earthquake in Sydney or Melbourne. Most of this damage will be due to the collapse of buildings. This research will develop a new form of ductile plating that will reduce the cost of retrofitting concrete bridges and buildings. This project will also help train two PhD students and one Research Associate and further enhance the existing collaboration between Australia and Italy.Read moreRead less
A unified reinforced concrete model for flexure and shear. The catastrophic Minnesota River Bridge collapse in the USA in 2007 highlighted the importance of accurately assessing, maintaining, upgrading and prolonging the design life of our aging infrastructure. The problem, which is just as severe in Australia, is further exacerbated by increasing man-made (terrorist) hazards and natural hazards such as earthquake, tsunami, flood and bushfire. Reinforced concrete and composite steel-concrete st ....A unified reinforced concrete model for flexure and shear. The catastrophic Minnesota River Bridge collapse in the USA in 2007 highlighted the importance of accurately assessing, maintaining, upgrading and prolonging the design life of our aging infrastructure. The problem, which is just as severe in Australia, is further exacerbated by increasing man-made (terrorist) hazards and natural hazards such as earthquake, tsunami, flood and bushfire. Reinforced concrete and composite steel-concrete structures comprise a very large part of Australia's bridge and building infrastructure. This project will provide a safe and more economical tool for engineers to both extend the working-life of existing infrastructure and design new infrastructure.Read moreRead less
Quantum Coherences in Artificial Light-Harvesting Complexes. The aim of this project is to relate efficient energy and electron transfer processes in molecular materials to the presence of quantum coherences. The ongoing debate on the role of quantum coherences in the efficient harvesting of sunlight of photosynthesis appears to be limited by the complexity of the biological systems and a lack of high instrumentation sensitivity. Using molecular systems and a highly sensitive method, this projec ....Quantum Coherences in Artificial Light-Harvesting Complexes. The aim of this project is to relate efficient energy and electron transfer processes in molecular materials to the presence of quantum coherences. The ongoing debate on the role of quantum coherences in the efficient harvesting of sunlight of photosynthesis appears to be limited by the complexity of the biological systems and a lack of high instrumentation sensitivity. Using molecular systems and a highly sensitive method, this project aims to reveal the effects of molecular conformation and geometry on quantum coherences. The outcome is likely to improve our understanding of nature's remarkable ability to harvest energy efficiently from the sun and foster new approaches that increase the efficiency of light-harvesting systems.Read moreRead less
Displacement-based earthquake design of unreinforced masonry walls in two-way bending. Current design of unreinforced masonry (URM) buildings for earthquake loading is based on checking that the strength of walls and connections exceeds the earthquake-induced inertia forces. Conservative estimates of wall bending strength are used to account for the wide variability in the quality of masonry construction. This project proposes to develop a new "displacement-based" design methodology for URM wa ....Displacement-based earthquake design of unreinforced masonry walls in two-way bending. Current design of unreinforced masonry (URM) buildings for earthquake loading is based on checking that the strength of walls and connections exceeds the earthquake-induced inertia forces. Conservative estimates of wall bending strength are used to account for the wide variability in the quality of masonry construction. This project proposes to develop a new "displacement-based" design methodology for URM walls which is less conservative and more direct, reliable and easier to apply the the force-based method. Hence, this method offers substantical cost savings over current techniques for the assessment of the seismic vulnerability of URM walls in buildings.Read moreRead less
Development of innovative fibre reinforced polymer plating techniques to retrofit existing reinforced concrete structures. The demand for retrofitting reinforced concrete structures in Australia is estimated at $500 million per annum. However, with improved understanding of emerging retrofitting techniques the cost of retrofitting may be reduced. The innovative retrofitting techniques investigated in this project will address the shortcomings of existing techniques with particular emphasis on th ....Development of innovative fibre reinforced polymer plating techniques to retrofit existing reinforced concrete structures. The demand for retrofitting reinforced concrete structures in Australia is estimated at $500 million per annum. However, with improved understanding of emerging retrofitting techniques the cost of retrofitting may be reduced. The innovative retrofitting techniques investigated in this project will address the shortcomings of existing techniques with particular emphasis on the ductility of the system which is a particularly important characteristic when retrofitting for earthquake or explosive loads. It also reinforces Australia's high international standing in developing innovative retrofitting alternatives using advanced materials in this rapidly developing area.Read moreRead less