Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237922
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
High Resolution Cryogenic Field Emission Environmental Scanning Electron Microscope Facility. A high resolution variable pressure scanning electron microscope will replace aging, heavily utilised facilities. It will be accessed by existing large and diverse user groups in a mature and internationally-recognised Centre. The novel combination of a cryogenic stage and the electrostatic beam blanking modification will support continuance of the local, world-leading research and application of new ....High Resolution Cryogenic Field Emission Environmental Scanning Electron Microscope Facility. A high resolution variable pressure scanning electron microscope will replace aging, heavily utilised facilities. It will be accessed by existing large and diverse user groups in a mature and internationally-recognised Centre. The novel combination of a cryogenic stage and the electrostatic beam blanking modification will support continuance of the local, world-leading research and application of new imaging techniques, particularly in the materials and mineral sciences. Both new nanotechnology and existing globally-significant industries will utilise the unique aspects of this instrument for product refinement and maintenance of commercial leadership, in partnership with local Universities and Government agencies.Read moreRead less
Trace element geochemistry of microbialites: towards an independent record of biogenicity, microbial communities, and seawater chemistry. A vast amount of Australia's mineral wealth is held in rocks of Precambrian age, yet those rocks are notoriously difficult to date and correlate owing to the rarity of fossils. Successful discrimination of different microbialites using biochemically sensitive trace elements will provide a firm basis and rationale for stromatolite biostratigraphy and greatly in ....Trace element geochemistry of microbialites: towards an independent record of biogenicity, microbial communities, and seawater chemistry. A vast amount of Australia's mineral wealth is held in rocks of Precambrian age, yet those rocks are notoriously difficult to date and correlate owing to the rarity of fossils. Successful discrimination of different microbialites using biochemically sensitive trace elements will provide a firm basis and rationale for stromatolite biostratigraphy and greatly increase our ability to understand the geological evolution and distribution of Precambrian rocks and resources. Additionally, a better understanding of the information content of stromatolites will yield considerable insight into the origin of life on Earth and its relationship to Earth's evolving chemistry and environment. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100118
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Nuclear magnetic resonance spectroscopy facilities for the Sydney region. The determination of molecular structure is crucial in the chemical and biomolecular sciences, leading to the development of new drugs and other types of molecules and providing an understanding of how molecules interact with each other. The requested equipment will provide the ability for researchers in the Sydney region to advance our knowledge at this fundamental level by expanding the number and types of experiments th ....Nuclear magnetic resonance spectroscopy facilities for the Sydney region. The determination of molecular structure is crucial in the chemical and biomolecular sciences, leading to the development of new drugs and other types of molecules and providing an understanding of how molecules interact with each other. The requested equipment will provide the ability for researchers in the Sydney region to advance our knowledge at this fundamental level by expanding the number and types of experiments that can be performed.Read moreRead less
Was there an unusual environment with equally remarkable inhabitants in Early Cretaceous southeast Australia? After more than two decades of effort, there is strong evidence that Early Cretaceous southeastern Australia was inhabited by a remarkably diverse polar terrestrial vertebrate fauna adapted to the coldest environment known to have existed anywhere in the late Mesozoic. In this unusual terrestrial habitat for that time, temnospondyl amphibians and allosaurid dinosaurs survived long ....Was there an unusual environment with equally remarkable inhabitants in Early Cretaceous southeast Australia? After more than two decades of effort, there is strong evidence that Early Cretaceous southeastern Australia was inhabited by a remarkably diverse polar terrestrial vertebrate fauna adapted to the coldest environment known to have existed anywhere in the late Mesozoic. In this unusual terrestrial habitat for that time, temnospondyl amphibians and allosaurid dinosaurs survived long after becoming extinct elsewhere. Here, too, are found what may be the oldest known and yet remarkably advanced placental mammals, the group to which we belong. To further corroborate or refute these hypotheses, some of which are highly contentious, is the aim of this project.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100135
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Federated single crystal X-ray structural analysis facility. X-ray crystallography is the most widely applied method for the determination of three-dimensional molecular structures. These structures range in size from small systems such as materials and pharmaceuticals through to large biological structures such as proteins. This application will provide a multidisciplinary facility covering the structural characterisation needs of chemistry, pharmacy, biology, and medicine. This will position l ....Federated single crystal X-ray structural analysis facility. X-ray crystallography is the most widely applied method for the determination of three-dimensional molecular structures. These structures range in size from small systems such as materials and pharmaceuticals through to large biological structures such as proteins. This application will provide a multidisciplinary facility covering the structural characterisation needs of chemistry, pharmacy, biology, and medicine. This will position local universities for key scientific breakthroughs that benefit the Australian community by providing improved healthcare technologies, and processes. Furthermore, access to this world-class facility will provide state-of-the-art training for undergraduate, postgraduate and postdoctoral researchers.Read moreRead less
Cretaceous marine reptiles from the Eromanga Sea - a research project focussing on the fossils of Outback Queensland. The Eromanga Sea covered large tracts of north and central Australia between 140 and 95 million years ago. Major faunal components of this inland-sea were marine reptiles, such as plesiosaurs, ichthyosaurs and sea turtles. North Qld has extensive marine fossil deposits remaining to be systematically explored. Many world-significant specimens from these strata are housed in the Au ....Cretaceous marine reptiles from the Eromanga Sea - a research project focussing on the fossils of Outback Queensland. The Eromanga Sea covered large tracts of north and central Australia between 140 and 95 million years ago. Major faunal components of this inland-sea were marine reptiles, such as plesiosaurs, ichthyosaurs and sea turtles. North Qld has extensive marine fossil deposits remaining to be systematically explored. Many world-significant specimens from these strata are housed in the Australian, Queensland and Richmond Marine Fossil museums. This project intends to resolve fundamental questions concerning the evolution, environment, lifestyle and distribution of Cretaceous marine reptiles by improving their fossil record and analysing newly discovered Australian specimens, including the world's first plesiosaur embryo.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561224
Funder
Australian Research Council
Funding Amount
$267,767.00
Summary
14CHRONOS (Chronologies from High-ResolutiON Organic Separations): a centre for radiocarbon dating of specific compounds for the environmental and archaeological sciences. Accurate timekeeping is central to the environmental and archaeological sciences. Radiocarbon dating is the leading geochronological technique for events of the past 50,000 years, but the issue for sample contamination remains a major source of concern. Avoidance of contaminants can be achieved through the identification of sp ....14CHRONOS (Chronologies from High-ResolutiON Organic Separations): a centre for radiocarbon dating of specific compounds for the environmental and archaeological sciences. Accurate timekeeping is central to the environmental and archaeological sciences. Radiocarbon dating is the leading geochronological technique for events of the past 50,000 years, but the issue for sample contamination remains a major source of concern. Avoidance of contaminants can be achieved through the identification of specific biomolecular compounds that unambiguously formed part of the original sample, and the isolation of these biomolecules for radiocarbon dating using accelerator mass spectrometry. Here we request funds to establish Australia's first compound-specific radiocarbon dating facility, to obtain ages of high accuracy for key studies of climate and landscape change, evolutionary biology and archaeology.Read moreRead less
Special Research Initiatives - Grant ID: SR0354775
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Synchrotron Sciences Network. A synchrotron light source is a critical piece of infrastructure for a modern technological nation. In 2001, the Victorian government announced that it would contribute $157M towards the establishment of a national synchrotron facility, becoming operational in 2007. The research performed at such a facility is exceedingly diverse, and often the underpinning technology is the only point of contact for users. A vibrant and productive facility requires a tra ....Australian Synchrotron Sciences Network. A synchrotron light source is a critical piece of infrastructure for a modern technological nation. In 2001, the Victorian government announced that it would contribute $157M towards the establishment of a national synchrotron facility, becoming operational in 2007. The research performed at such a facility is exceedingly diverse, and often the underpinning technology is the only point of contact for users. A vibrant and productive facility requires a transparent interface between the scientist and the technology. This Network will set up the communication channels within the user base, and between the users and the facility development program.Read moreRead less
Synthesis, Biological Interactions and Toxicity Studies of Precisely Engineered Nanoparticles. The proposed benefits of nanotechnology for industries from material sciences, to bioengineering, energy and the environment are currently driving unprecedented growth in this technology world-wide. Some of these benefits are borne out of the unique properties that different nanoparticles exhibit. However, if nanomaterials pose a threat to the health and well-being of the community, then their risks ....Synthesis, Biological Interactions and Toxicity Studies of Precisely Engineered Nanoparticles. The proposed benefits of nanotechnology for industries from material sciences, to bioengineering, energy and the environment are currently driving unprecedented growth in this technology world-wide. Some of these benefits are borne out of the unique properties that different nanoparticles exhibit. However, if nanomaterials pose a threat to the health and well-being of the community, then their risks may outweigh their benefits. This project will identify those characteristics of nanoparticles that can lead to adverse effects and therefore pose a danger to the general community. By defining these characteristics, appropriate changes in nanomaterial production can be considered by industry to minimise these dangers.Read moreRead less
Allosteric regulation, molecular structure and function of transglutaminase 2. With Australia's ageing population, we can expect to see increasing prevalence of pathologies such as cancer, Alzheimer's disease, and cataracts. The ubiquitous enzyme transglutaminase 2 (TG2) has been implicated in all of these age-related diseases, as well as in chronic disorders such as coeliac disease and diabetes, and may contribute in a positive way to wound healing. Understanding how TG2 is activated and inac ....Allosteric regulation, molecular structure and function of transglutaminase 2. With Australia's ageing population, we can expect to see increasing prevalence of pathologies such as cancer, Alzheimer's disease, and cataracts. The ubiquitous enzyme transglutaminase 2 (TG2) has been implicated in all of these age-related diseases, as well as in chronic disorders such as coeliac disease and diabetes, and may contribute in a positive way to wound healing. Understanding how TG2 is activated and inactivated, and how it selects its targets, will be a critical addition to current knowledge of this enzyme, and will be an essential prerequisite for the development of TG2-targetted drugs and other TG2-related therapies.Read moreRead less