Methods for Protein Structure Analysis by Electron Paramagnetic Resonance. This highly interdisciplinary project aims to establish new tools to analyse the structure and motions of proteins that are otherwise difficult to study. A combination of advanced biochemistry, modern magnetic spectroscopy methods, and high-performance computing techniques will be applied to study proteins at physiological concentrations and in complex environments. New techniques will be developed and tested on proteins ....Methods for Protein Structure Analysis by Electron Paramagnetic Resonance. This highly interdisciplinary project aims to establish new tools to analyse the structure and motions of proteins that are otherwise difficult to study. A combination of advanced biochemistry, modern magnetic spectroscopy methods, and high-performance computing techniques will be applied to study proteins at physiological concentrations and in complex environments. New techniques will be developed and tested on proteins of high biochemical or biomedical importance, and the approach will be applied to established drug targets.Read moreRead less
Efficient phylogenetic methods that manage the curse of genomic complexity. This project aims to develop new methods and software to infer the evolutionary history of organisms using genomic data. These new phylogenomic methods need to take account of the complexity of evolutionary processes and/or patterns in time (along the evolutionary tree) and space (along the genome). This project is significant because these methods must merge mathematics and statistics with High-Performance Computing to ....Efficient phylogenetic methods that manage the curse of genomic complexity. This project aims to develop new methods and software to infer the evolutionary history of organisms using genomic data. These new phylogenomic methods need to take account of the complexity of evolutionary processes and/or patterns in time (along the evolutionary tree) and space (along the genome). This project is significant because these methods must merge mathematics and statistics with High-Performance Computing to handle the huge quantities of genetic data and the complexity of evolution itself. An important expected outcome of this project will be the development and release of freely-available software that incorporates these new methods. This project expects to benefit scientists who need to infer phylogenies from genomic data. Read moreRead less
Unlocking the diverse property profile of ultra-lightweight magnesium alloys. This project aims to develop the theory behind why micro alloying contributes to the formation of surface film properties. The exemplar is a prototype Magnesium-Lithium (Mg-Li) base alloy, with high specific-strength and corrosion resistance. This project will lead to the development of a new processable ultra-lightweight, corrosion resistant Mg-Li alloy family that is stronger than the prototype alloy, and with, at le ....Unlocking the diverse property profile of ultra-lightweight magnesium alloys. This project aims to develop the theory behind why micro alloying contributes to the formation of surface film properties. The exemplar is a prototype Magnesium-Lithium (Mg-Li) base alloy, with high specific-strength and corrosion resistance. This project will lead to the development of a new processable ultra-lightweight, corrosion resistant Mg-Li alloy family that is stronger than the prototype alloy, and with, at least, comparable ductility and corrosion resistance. Not only will the outcomes of the work be a fundamental advance to the fields of metallurgy and corrosion science, they will lead to the identification of an optimised compositional window for creating our second generation Mg-Li alloy family capable of being manufactured into ultra-lightweight, corrosion resistant metal products.Read moreRead less
Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive econom ....Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive economic opportunity. However, the high flammability and low ignition energy of hydrogen makes it vulnerable to accidental explosions. Hence, this project will address the lack of safety protocols in Australian Standards related to the handling of hydrogen by producing essential design recommendations.Read moreRead less
Inequality, Prosperity and the Australian Welfare State. This project aims to clarify contested understandings of Australian inequality and the role of economic and social policies in addressing policy challenges going forward. The objective of the project is to generate significantly improved knowledge of inequality in Australia using innovative approaches of data splicing, decomposition, simulation and backcasting to fill research gaps and resolve contested interpretations. We aim to provide a ....Inequality, Prosperity and the Australian Welfare State. This project aims to clarify contested understandings of Australian inequality and the role of economic and social policies in addressing policy challenges going forward. The objective of the project is to generate significantly improved knowledge of inequality in Australia using innovative approaches of data splicing, decomposition, simulation and backcasting to fill research gaps and resolve contested interpretations. We aim to provide a benchmark and robust framework against which policy development after the current crisis can be evaluated. This project aims to provide significant benefits, keeping Australia at the forefront of research on inequality and public policy, strengthening links between researchers and policy makers.
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Dynamic evolution of mutation rates: causes and impacts on genomic analysis. This project aims to illuminate the role of variation in mutation rate in driving evolutionary change. Mutation rate is a core parameter in evolutionary analyses in essential applications including epidemiology, conservation and medicine, yet remains a “black box” given arbitrary universal values. This project will take a whole-of-biodiversity approach to understanding the forces shaping mutation rate, impact on evoluti ....Dynamic evolution of mutation rates: causes and impacts on genomic analysis. This project aims to illuminate the role of variation in mutation rate in driving evolutionary change. Mutation rate is a core parameter in evolutionary analyses in essential applications including epidemiology, conservation and medicine, yet remains a “black box” given arbitrary universal values. This project will take a whole-of-biodiversity approach to understanding the forces shaping mutation rate, impact on evolution of biodiversity and effect on accuracy and precision of phylogenetic analyses. Using Australian case studies, the expected outcome of this project will be a greater understanding variation in mutation rate between species, providing significant benefits in developing more sophisticated and reliable phylogenetic analyses.Read moreRead less
Bioinspired tuneable catalysts for renewable ammonia production. The project will design a new solar-powered system for electrosynthesis of ammonia to replace the current energy intensive, non-sustainable process that generates 1.5% of global CO2 emissions. An innovative new system will be developed by combining cutting edge electrochemical, spectroscopic and theoretical methods. Expected key outcomes include novel concepts in the design of advanced materials, and an efficient process for the gr ....Bioinspired tuneable catalysts for renewable ammonia production. The project will design a new solar-powered system for electrosynthesis of ammonia to replace the current energy intensive, non-sustainable process that generates 1.5% of global CO2 emissions. An innovative new system will be developed by combining cutting edge electrochemical, spectroscopic and theoretical methods. Expected key outcomes include novel concepts in the design of advanced materials, and an efficient process for the green ammonia synthesis. Given the strategic importance of ammonia as a future energy carrier for the export of Australian renewables and as a major source of fertilisers, this project should provide significant national economic and ecological benefits and is expected to have a broad reaching global impact.Read moreRead less
A new energy absorption system for brain injury mitigation. This research aims to propose and investigate a next generation high-energy absorbing helmet pad that will protect the Australian Defence Force soldiers against both ballistic and blast threats. New fundamental knowledge in the area of high-energy absorbing metamaterials will be obtained by using numerical modelling and experimental studies. The expected outcomes of the project include the development of a new wearable energy absorbing ....A new energy absorption system for brain injury mitigation. This research aims to propose and investigate a next generation high-energy absorbing helmet pad that will protect the Australian Defence Force soldiers against both ballistic and blast threats. New fundamental knowledge in the area of high-energy absorbing metamaterials will be obtained by using numerical modelling and experimental studies. The expected outcomes of the project include the development of a new wearable energy absorbing pad which can be used as the next generation combat helmet liners and accessories. The novel high-performance energy absorption system will have a wide range of direct applications in future personal armour, as well as sports gears and elderly healthcare products.Read moreRead less
Australia's Resilience to Recession. This project aims to study why Australia differs from its OECD peers in that it has not had a recession for 27 years. It intends to generate knowledge by using economic models to solve 3 puzzles relating to Australia’s success: (i) why did foreign financial market shocks not spill over to the economy?; (ii) how has the resource curse that affects economies with a booming resource sector been avoided?; and (iii) what makes Australia special? Expected outcomes ....Australia's Resilience to Recession. This project aims to study why Australia differs from its OECD peers in that it has not had a recession for 27 years. It intends to generate knowledge by using economic models to solve 3 puzzles relating to Australia’s success: (i) why did foreign financial market shocks not spill over to the economy?; (ii) how has the resource curse that affects economies with a booming resource sector been avoided?; and (iii) what makes Australia special? Expected outcomes include the development of theoretical and empirical models that reflect the unique features of the Australian economy. This should provide significant benefits, including guidance to Australian and international policymakers on macroeconomic policies for resource-rich countries.Read moreRead less
Global wavefront propagation and non-elliptic Fredholm theory. Many significant phenomena in the natural world are described by partial differential equations that involve evolution in time. This project aims to develop new mathematical methods, involving recently discovered global wavefront set analysis and Fredholm theory, to solve such equations. These methods aim to extend the range of equations that can be solved as well as yield more information about solutions, in particular, their long-t ....Global wavefront propagation and non-elliptic Fredholm theory. Many significant phenomena in the natural world are described by partial differential equations that involve evolution in time. This project aims to develop new mathematical methods, involving recently discovered global wavefront set analysis and Fredholm theory, to solve such equations. These methods aim to extend the range of equations that can be solved as well as yield more information about solutions, in particular, their long-time asymptotics.Read moreRead less