Tapasin And Major Histocompatibility Complex Class I Antigen Presentation
Funder
National Health and Medical Research Council
Funding Amount
$226,650.00
Summary
An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. ....An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. This research proposal aims to examine the role of tapasin in this regard. A thorough understanding of the basic principles of peptide presentation to T cells is crucial to the design of effective vaccines. Furthermore it will also broaden our understanding of immunological responses to cancer, autoimmune diseases and infections.Read moreRead less
The Aboriginal Cardiovascular Omega-3 Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,090,119.00
Summary
CVD is the primary contributor to life expectancy differentials between Indigenous and non-Indigenous Australians. Even when cardioprotective therapies are optimally used, residual risk of adverse events is often observed. Testing of additional therapies that improve survival among Indigenous people with CVD is required. Omega 3 fatty acids can improve multiple atherogenic pathways. This trial will assess the impact of Omega 3 in Aboriginal patients with CVD.
Creating better pathways into civic participation for young homeless people through sustainable accommodation and support program models. A sustained independent living environment is a significant contributor to health and well being. This project will offer new insights into how young homeless people use and experience supported accommodation and programs. It will recommend practical models for policy development, practice and service delivery.
Quantum Coherences in Artificial Light-Harvesting Complexes. The aim of this project is to relate efficient energy and electron transfer processes in molecular materials to the presence of quantum coherences. The ongoing debate on the role of quantum coherences in the efficient harvesting of sunlight of photosynthesis appears to be limited by the complexity of the biological systems and a lack of high instrumentation sensitivity. Using molecular systems and a highly sensitive method, this projec ....Quantum Coherences in Artificial Light-Harvesting Complexes. The aim of this project is to relate efficient energy and electron transfer processes in molecular materials to the presence of quantum coherences. The ongoing debate on the role of quantum coherences in the efficient harvesting of sunlight of photosynthesis appears to be limited by the complexity of the biological systems and a lack of high instrumentation sensitivity. Using molecular systems and a highly sensitive method, this project aims to reveal the effects of molecular conformation and geometry on quantum coherences. The outcome is likely to improve our understanding of nature's remarkable ability to harvest energy efficiently from the sun and foster new approaches that increase the efficiency of light-harvesting systems.Read moreRead less
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989336
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are ....The South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination. The precise three dimensional arrangement of atoms within molecular and macromolecular structures defines their function. Thus, the discovery, development and application of biological compounds, catalysts, nanodevices and pharmaceuticals require X-ray diffraction structure determination. These endeavours underpin the conversion of academic research into real benefits for the community and are critical for the competitiveness of Australian industry, national productivity and economic growth. This application seeks to provide a facility for multidisciplinary scientific development that will enhance academic-industrial collaboration. This will position SA research community for scientific breakthroughs that benefit the Australian community.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101178
Funder
Australian Research Council
Funding Amount
$344,324.00
Summary
Water Harvesting and the Cultural Politics of Resource Equity. This project aims to provide a new framework for understanding water equity challenges in urban South Asia. Equitable water access is an everyday struggle in this region. For example, in New Delhi, millions suffer from inadequate supplies, while the wealthy enjoy more than their share. The project plans to investigate how people respond to water stress by adopting techniques such as water harvesting. It also plans to examine the degr ....Water Harvesting and the Cultural Politics of Resource Equity. This project aims to provide a new framework for understanding water equity challenges in urban South Asia. Equitable water access is an everyday struggle in this region. For example, in New Delhi, millions suffer from inadequate supplies, while the wealthy enjoy more than their share. The project plans to investigate how people respond to water stress by adopting techniques such as water harvesting. It also plans to examine the degree to which water harvesting leads to social inclusion or exclusion. Through ethnographic examinations of the water values, resource subjectivities and power dynamics that influence the success of urban water harvesting, the projects intends to gain insights to improve regional water policy and aid effectiveness.Read moreRead less
From high school to higher education: Gendered pathways in information, communication and computer technology education. Serious gender-based disparities exist in participation in the Information, Communication, and Computing Technologies (ICCT) field, in both higher education and industry, with a 2004 review of Australian university participation rates identifying women as an equity target group in this field. A multi-method, multi-stage project has been design to identify the processes that le ....From high school to higher education: Gendered pathways in information, communication and computer technology education. Serious gender-based disparities exist in participation in the Information, Communication, and Computing Technologies (ICCT) field, in both higher education and industry, with a 2004 review of Australian university participation rates identifying women as an equity target group in this field. A multi-method, multi-stage project has been design to identify the processes that lead to this gender gap. Specifically, the project will focus on students' experiences and decisions at secondary school in three states to ascertain why so few girls choose to enter university-level ICCT courses, and what strategies could be implemented in schools to remedy this problem. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100111
Funder
Australian Research Council
Funding Amount
$373,329.00
Summary
A History of Intimate Relationships in Scotland: Emotion and Family among the Lower Orders, 1661-1830. This project will provide a comprehensive and novel analysis of intimate relationships amongst the Scottish lower orders between 1661 and 1830, filling a gap in the European/Anglophone research on the emotional lives of the poor. It will use an innovative methodology to access emotions amongst a group who did not leave traditional 'feeling' sources, such as letters and diaries, to create a pict ....A History of Intimate Relationships in Scotland: Emotion and Family among the Lower Orders, 1661-1830. This project will provide a comprehensive and novel analysis of intimate relationships amongst the Scottish lower orders between 1661 and 1830, filling a gap in the European/Anglophone research on the emotional lives of the poor. It will use an innovative methodology to access emotions amongst a group who did not leave traditional 'feeling' sources, such as letters and diaries, to create a picture of their emotional and familial world. Its novel methodology will supply a model for doing similar work in other contexts, while its insights into how this group formed families, and used emotions in that process, will provide historical data that can inform social policy and strengthen Australia's social and economic fabric.Read moreRead less
Self-zoning in natural uraninite: radiation driven chemical separation. In this project we aim to explore and define the effects of the substitution of lead and rare earths on the crystal chemistry of uranium dioxide (uraninite) and related minerals, towards establishing the oxygen stoichiometry (as a measure of oxygen fugacity) of these materials both in nature and in synthetic materials. This project will use synthetic materials to understand the variability of oxygen stoichiometry, establish ....Self-zoning in natural uraninite: radiation driven chemical separation. In this project we aim to explore and define the effects of the substitution of lead and rare earths on the crystal chemistry of uranium dioxide (uraninite) and related minerals, towards establishing the oxygen stoichiometry (as a measure of oxygen fugacity) of these materials both in nature and in synthetic materials. This project will use synthetic materials to understand the variability of oxygen stoichiometry, establish accurate and precise structures for the oxides, and distinguish both long range and short-range order which is critical to understanding both natural and synthetic U-oxides. This will help to define the geochemical conditions leading to the formation of deposits like Olympic Dam towards potential economic benefit.Read moreRead less